PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2566191-3	1989	Somatostatin inhibited ion secretion evoked by EFS (55-65%), carbachol (80%) and VIP (95%) in a dose-dependent manner.	Carbachol	61-70	somatostatin	Rattus norvegicus	0-12	
2896351-2	1988	Pretreatment of pancreatic acini at 37 degrees C for 120 min with not only pancreatic secretagogues, such as carbachol and bombesin, but also vasoactive intestinal peptide (VIP) and secretin reduced subsequent labeled somatostatin binding to the acinar membranes in a dose-dependent manner.	Carbachol	109-118	somatostatin	Rattus norvegicus	218-230	
2577684-3	1989	Both glucose and theophylline stimulation gave significant increases in somatostatin secretion, whereas carbachol inhibits the somatostatin secretion at 25 mmol l-1 glucose but not at 5 mmol l-1 glucose.	Carbachol	104-113	somatostatin	Rattus norvegicus	127-139	
2896351-7	1988	Furthermore, the inhibitory effect of carbachol was attenuated by the presence of 1 mM EDTA in media for pretreatment, suggesting that intracellular pathways activated by pancreatic secretagogues may be responsible for somatostatin receptor modulation.	Carbachol	38-47	somatostatin	Rattus norvegicus	219-231	
2896351-8	1988	Interestingly, when combined with VIP, pretreatment of acini with carbachol produced an additive inhibition of labeled somatostatin binding to the membranes.	Carbachol	66-75	somatostatin	Rattus norvegicus	119-131	
44657-1	1979	The perfused stomach in the anaesthetized rat was used to investigate the action of somatostatin on the gastric acid secretion stimulated by gastrin, histamine and carbamylcholine.	Carbachol	164-179	somatostatin	Rattus norvegicus	84-96	
6144613-2	1984	The purpose of this study was to examine further the relationships between gastrin and somatostatin and the effects of the cholinergic agonist carbachol on content and release of gastrin and somatostatin using rat antral mucosa in tissue culture.	Carbachol	143-152	somatostatin	Rattus norvegicus	191-203	
6144613-5	1984	Inclusion of carbachol 2.5 X 10(-6) M in the culture medium decreased medium somatostatin from 1.91 +/- 0.28 (SEM) ng/mg tissue protein to 0.62 +/- 0.12 ng/mg (p less than 0.01), extracted mucosal somatostatin from 2.60 +/- 0.30 to 1.52 +/- 0.16 ng/mg (p less than 0.001), and percentage of somatostatin released from 42% +/- 2.6% to 27% +/- 2.2% (p less than 0.01).	Carbachol	13-22	somatostatin	Rattus norvegicus	77-89	
6144613-5	1984	Inclusion of carbachol 2.5 X 10(-6) M in the culture medium decreased medium somatostatin from 1.91 +/- 0.28 (SEM) ng/mg tissue protein to 0.62 +/- 0.12 ng/mg (p less than 0.01), extracted mucosal somatostatin from 2.60 +/- 0.30 to 1.52 +/- 0.16 ng/mg (p less than 0.001), and percentage of somatostatin released from 42% +/- 2.6% to 27% +/- 2.2% (p less than 0.01).	Carbachol	13-22	somatostatin	Rattus norvegicus	197-209	
6144613-5	1984	Inclusion of carbachol 2.5 X 10(-6) M in the culture medium decreased medium somatostatin from 1.91 +/- 0.28 (SEM) ng/mg tissue protein to 0.62 +/- 0.12 ng/mg (p less than 0.01), extracted mucosal somatostatin from 2.60 +/- 0.30 to 1.52 +/- 0.16 ng/mg (p less than 0.001), and percentage of somatostatin released from 42% +/- 2.6% to 27% +/- 2.2% (p less than 0.01).	Carbachol	13-22	somatostatin	Rattus norvegicus	197-209	
6144613-8	1984	Incubation with somatostatin antisera, both with and without carbachol, markedly increased culture media concentrations of somatostatin, all of which was effectively bound by antibodies present in the media.	Carbachol	61-70	somatostatin	Rattus norvegicus	123-135	
6144613-9	1984	Antibody binding of somatostatin was accompanied by significant increases in culture media gastrin concentrations, both in the presence and in the absence of carbachol.	Carbachol	158-167	somatostatin	Rattus norvegicus	20-32	
6129701-1	1983	Somatostatin, a tetradecapeptide with potent inhibitory actions on gastric acid secretion, potentiated carbamylcholine-induced synthesis and release of prostaglandin E2 from isolated perfused rat stomachs.	Carbachol	103-118	somatostatin	Rattus norvegicus	0-12	
6117361-6	1981	intravenous infusion of carbachol (1 microgram.kg-1.min-1) strongly stimulated luminal somatostatin and gastrin release (from 5 +/- 1 to 192 +/- 52 pg.mL-1 and from 27 +/- 5 to 198 +/- 41 pg.mL-1, respectively) during perfusion with 0.1 M HCl.	Carbachol	24-33	somatostatin	Rattus norvegicus	87-99	
1361226-0	1992	Effect of carbachol on luminal release of somatostatin from isolated perfused rat duodenum.	Carbachol	10-19	somatostatin	Rattus norvegicus	42-54	
8097916-5	1993	In addition, the increase in somatostatin secretion induced by incubation with veratridine (10(-4) M) or carbachol (10(-4) M) for 90 min was significantly reduced by the addition of caprylic acid, but somatostatin release stimulated by 5.6 x 10(-2) M KCl was not affected.	Carbachol	105-114	somatostatin	Rattus norvegicus	29-41	
8097916-5	1993	In addition, the increase in somatostatin secretion induced by incubation with veratridine (10(-4) M) or carbachol (10(-4) M) for 90 min was significantly reduced by the addition of caprylic acid, but somatostatin release stimulated by 5.6 x 10(-2) M KCl was not affected.	Carbachol	105-114	somatostatin	Rattus norvegicus	201-213	
8093872-1	1993	We have examined the release of gastrin and somatostatin from the isolated perfused stomach of rats of three different age groups (4 months, 12 months, and 24 months old) in response to bombesin and carbachol.	Carbachol	199-208	somatostatin	Rattus norvegicus	44-56	
8093872-7	1993	Carbachol inhibited release of somatostatin in each age group.	Carbachol	0-9	somatostatin	Rattus norvegicus	31-43	
8093872-8	1993	Compared with 4-month-old rats, the inhibition of somatostatin release by carbachol was less in 24-month-old rats at 10(-8) and 10(-7) M, and less in 12-month-old rats at 10(-7) M. The decreased basal gastrin secretion and well-preserved gastrin response were further confirmed in conscious aged rats tested by means of oral gavage with 10% peptone.	Carbachol	74-83	somatostatin	Rattus norvegicus	50-62	
1361226-4	1992	The ratio of somatostatin-14 to somatostatin-28 in picograms was about 1 during basal release but increased to approximately 2 during carbachol stimulation.	Carbachol	134-143	somatostatin	Rattus norvegicus	13-25	
1706667-6	1990	SS-14 also attenuated secretory responses produced by carbachol, substance P (SP), VIP and alpha- and beta-calcitonin gene related peptide (alpha-, beta-CGRP).	Carbachol	54-63	somatostatin	Rattus norvegicus	0-5	
1980640-5	1990	Somatostatin inhibited carbachol- and cholecystokinin octapeptide-induced pepsinogen secretion from dispersed gastric mucosal cells in a dose-dependent manner.	Carbachol	23-32	somatostatin	Rattus norvegicus	0-12