PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8093872-1 1993 We have examined the release of gastrin and somatostatin from the isolated perfused stomach of rats of three different age groups (4 months, 12 months, and 24 months old) in response to bombesin and carbachol. Carbachol 199-208 somatostatin Rattus norvegicus 44-56 8097916-5 1993 In addition, the increase in somatostatin secretion induced by incubation with veratridine (10(-4) M) or carbachol (10(-4) M) for 90 min was significantly reduced by the addition of caprylic acid, but somatostatin release stimulated by 5.6 x 10(-2) M KCl was not affected. Carbachol 105-114 somatostatin Rattus norvegicus 29-41 8097916-5 1993 In addition, the increase in somatostatin secretion induced by incubation with veratridine (10(-4) M) or carbachol (10(-4) M) for 90 min was significantly reduced by the addition of caprylic acid, but somatostatin release stimulated by 5.6 x 10(-2) M KCl was not affected. Carbachol 105-114 somatostatin Rattus norvegicus 201-213 8093872-7 1993 Carbachol inhibited release of somatostatin in each age group. Carbachol 0-9 somatostatin Rattus norvegicus 31-43 8093872-8 1993 Compared with 4-month-old rats, the inhibition of somatostatin release by carbachol was less in 24-month-old rats at 10(-8) and 10(-7) M, and less in 12-month-old rats at 10(-7) M. The decreased basal gastrin secretion and well-preserved gastrin response were further confirmed in conscious aged rats tested by means of oral gavage with 10% peptone. Carbachol 74-83 somatostatin Rattus norvegicus 50-62 1980640-5 1990 Somatostatin inhibited carbachol- and cholecystokinin octapeptide-induced pepsinogen secretion from dispersed gastric mucosal cells in a dose-dependent manner. Carbachol 23-32 somatostatin Rattus norvegicus 0-12 1361226-0 1992 Effect of carbachol on luminal release of somatostatin from isolated perfused rat duodenum. Carbachol 10-19 somatostatin Rattus norvegicus 42-54 1361226-4 1992 The ratio of somatostatin-14 to somatostatin-28 in picograms was about 1 during basal release but increased to approximately 2 during carbachol stimulation. Carbachol 134-143 somatostatin Rattus norvegicus 13-25 1706667-6 1990 SS-14 also attenuated secretory responses produced by carbachol, substance P (SP), VIP and alpha- and beta-calcitonin gene related peptide (alpha-, beta-CGRP). Carbachol 54-63 somatostatin Rattus norvegicus 0-5 2896351-2 1988 Pretreatment of pancreatic acini at 37 degrees C for 120 min with not only pancreatic secretagogues, such as carbachol and bombesin, but also vasoactive intestinal peptide (VIP) and secretin reduced subsequent labeled somatostatin binding to the acinar membranes in a dose-dependent manner. Carbachol 109-118 somatostatin Rattus norvegicus 218-230 2566191-3 1989 Somatostatin inhibited ion secretion evoked by EFS (55-65%), carbachol (80%) and VIP (95%) in a dose-dependent manner. Carbachol 61-70 somatostatin Rattus norvegicus 0-12 2577684-3 1989 Both glucose and theophylline stimulation gave significant increases in somatostatin secretion, whereas carbachol inhibits the somatostatin secretion at 25 mmol l-1 glucose but not at 5 mmol l-1 glucose. Carbachol 104-113 somatostatin Rattus norvegicus 127-139 2896351-7 1988 Furthermore, the inhibitory effect of carbachol was attenuated by the presence of 1 mM EDTA in media for pretreatment, suggesting that intracellular pathways activated by pancreatic secretagogues may be responsible for somatostatin receptor modulation. Carbachol 38-47 somatostatin Rattus norvegicus 219-231 2896351-8 1988 Interestingly, when combined with VIP, pretreatment of acini with carbachol produced an additive inhibition of labeled somatostatin binding to the membranes. Carbachol 66-75 somatostatin Rattus norvegicus 119-131 6144613-2 1984 The purpose of this study was to examine further the relationships between gastrin and somatostatin and the effects of the cholinergic agonist carbachol on content and release of gastrin and somatostatin using rat antral mucosa in tissue culture. Carbachol 143-152 somatostatin Rattus norvegicus 191-203 6144613-5 1984 Inclusion of carbachol 2.5 X 10(-6) M in the culture medium decreased medium somatostatin from 1.91 +/- 0.28 (SEM) ng/mg tissue protein to 0.62 +/- 0.12 ng/mg (p less than 0.01), extracted mucosal somatostatin from 2.60 +/- 0.30 to 1.52 +/- 0.16 ng/mg (p less than 0.001), and percentage of somatostatin released from 42% +/- 2.6% to 27% +/- 2.2% (p less than 0.01). Carbachol 13-22 somatostatin Rattus norvegicus 77-89 6144613-5 1984 Inclusion of carbachol 2.5 X 10(-6) M in the culture medium decreased medium somatostatin from 1.91 +/- 0.28 (SEM) ng/mg tissue protein to 0.62 +/- 0.12 ng/mg (p less than 0.01), extracted mucosal somatostatin from 2.60 +/- 0.30 to 1.52 +/- 0.16 ng/mg (p less than 0.001), and percentage of somatostatin released from 42% +/- 2.6% to 27% +/- 2.2% (p less than 0.01). Carbachol 13-22 somatostatin Rattus norvegicus 197-209 6144613-5 1984 Inclusion of carbachol 2.5 X 10(-6) M in the culture medium decreased medium somatostatin from 1.91 +/- 0.28 (SEM) ng/mg tissue protein to 0.62 +/- 0.12 ng/mg (p less than 0.01), extracted mucosal somatostatin from 2.60 +/- 0.30 to 1.52 +/- 0.16 ng/mg (p less than 0.001), and percentage of somatostatin released from 42% +/- 2.6% to 27% +/- 2.2% (p less than 0.01). Carbachol 13-22 somatostatin Rattus norvegicus 197-209 6144613-8 1984 Incubation with somatostatin antisera, both with and without carbachol, markedly increased culture media concentrations of somatostatin, all of which was effectively bound by antibodies present in the media. Carbachol 61-70 somatostatin Rattus norvegicus 123-135 6144613-9 1984 Antibody binding of somatostatin was accompanied by significant increases in culture media gastrin concentrations, both in the presence and in the absence of carbachol. Carbachol 158-167 somatostatin Rattus norvegicus 20-32 6129701-1 1983 Somatostatin, a tetradecapeptide with potent inhibitory actions on gastric acid secretion, potentiated carbamylcholine-induced synthesis and release of prostaglandin E2 from isolated perfused rat stomachs. Carbachol 103-118 somatostatin Rattus norvegicus 0-12 6117361-6 1981 intravenous infusion of carbachol (1 microgram.kg-1.min-1) strongly stimulated luminal somatostatin and gastrin release (from 5 +/- 1 to 192 +/- 52 pg.mL-1 and from 27 +/- 5 to 198 +/- 41 pg.mL-1, respectively) during perfusion with 0.1 M HCl. Carbachol 24-33 somatostatin Rattus norvegicus 87-99 44657-1 1979 The perfused stomach in the anaesthetized rat was used to investigate the action of somatostatin on the gastric acid secretion stimulated by gastrin, histamine and carbamylcholine. Carbachol 164-179 somatostatin Rattus norvegicus 84-96