PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7889307-16 1994 Inclusion of SNP (0.01-1 microM) or 8Br-cyclic GMP (50 microM) in the Ca2+-free medium inhibited the transient residual response to carbachol. Carbachol 132-141 5'-nucleotidase, cytosolic II Mus musculus 47-50 7889307-17 1994 Inclusion of similar concentrations of SNP or 8Br-cyclic GMP,during Ca2+ re-loading, increased the subsequent residual contraction to carbachol in Ca2+-free medium.7. Carbachol 134-143 5'-nucleotidase, cytosolic II Mus musculus 57-60 3018477-5 1986 Carbachol mediated cyclic GMP formation with an equilibrium dissociation constant (KD) of 325 microM and cyclic AMP reductions with a KD value of 13 microM. Carbachol 0-9 5'-nucleotidase, cytosolic II Mus musculus 26-29 7509388-4 1994 Carbachol increased cyclic GMP formation in the mixture of cells in a time- and concentration-dependent manner, with a half-maximal response occurring in the nanomolar range. Carbachol 0-9 5'-nucleotidase, cytosolic II Mus musculus 27-30 1686865-3 1991 Here we report the time course of the appearance of the 3,5-dibromo-4-nitrosobenzene sulfonate (DBNBS) spin adduct and cyclic GMP formation following addition of carbamylcholine to suspensions of cultured mouse neuroblastoma cells (clone N1E-115). Carbachol 162-177 5'-nucleotidase, cytosolic II Mus musculus 126-129 1700270-8 1990 Cyclic GMP levels were also enhanced by carbachol plus isoproterenol. Carbachol 40-49 5'-nucleotidase, cytosolic II Mus musculus 7-10 2167677-2 1990 After a 45-min incubation at 37 degrees of N1E-115 cells either in monolayer or in suspension, with the muscarinic agonist carbachol (1 mM), the receptor-mediated cyclic GMP response to carbachol was nearly completely lost. Carbachol 123-132 5'-nucleotidase, cytosolic II Mus musculus 170-173 2167677-2 1990 After a 45-min incubation at 37 degrees of N1E-115 cells either in monolayer or in suspension, with the muscarinic agonist carbachol (1 mM), the receptor-mediated cyclic GMP response to carbachol was nearly completely lost. Carbachol 186-195 5'-nucleotidase, cytosolic II Mus musculus 170-173 3033212-1 1987 The effects of phorbol 12-myristate 13-acetate (PMA) on carbamylcholine (CBC)-induced [3H]cyclic GMP formation in mouse neuroblastoma cells (clone N1E-115) were studied. Carbachol 56-71 5'-nucleotidase, cytosolic II Mus musculus 97-100 3033212-1 1987 The effects of phorbol 12-myristate 13-acetate (PMA) on carbamylcholine (CBC)-induced [3H]cyclic GMP formation in mouse neuroblastoma cells (clone N1E-115) were studied. Carbachol 73-76 5'-nucleotidase, cytosolic II Mus musculus 97-100 1646447-4 1991 In contrast to the results obtained with the binding experiments using antagonists, the study of the cellular cyclic nucleotide response upon carbachol stimulation suggested the presence of both the M1 and M2 subtypes as there was an increase in cyclic GMP concentration while at the same time, the prostaglandin-stimulated synthesis of cyclic AMP was inhibited. Carbachol 142-151 5'-nucleotidase, cytosolic II Mus musculus 253-256 3037024-6 1987 All three of these monoHETEs were shown also to be inhibitors of the cyclic GMP responses to receptors stimulated by carbachol, histamine, thrombin, neurotensin, and bradykinin. Carbachol 117-126 5'-nucleotidase, cytosolic II Mus musculus 76-79 2868120-2 1986 Using intact cells, we found that although ethanol had no effect on basal levels of cyclic GMP synthesis, it rapidly inhibited in a concentration-dependent manner cyclic GMP synthesis mediated by the agonists histamine (histamine H1 receptor) and carbachol (low-affinity muscarinic receptor) and by ionophore X537A and melittin, agents which bypass these receptors. Carbachol 247-256 5'-nucleotidase, cytosolic II Mus musculus 170-173 6148690-7 1984 A normal [3H]cyclic GMP response to bradykinin and histamine was demonstrated to be present in cells that had lost the [3H]cyclic GMP response to carbachol. Carbachol 146-155 5'-nucleotidase, cytosolic II Mus musculus 20-23 2994150-3 1985 We have reported that lithium ion (Li+) inhibits cyclic GMP formation mediated by the muscarinic receptor agonist, carbachol, in a concentration-dependent manner and that neither ammonium nor sodium ions have such an effect. Carbachol 115-124 5'-nucleotidase, cytosolic II Mus musculus 56-59 2982089-4 1985 Pirenzepine inhibited the [3H]cyclic GMP response to carbachol with a KD value of approximately 6 nM, whereas it inhibited the ability of carbachol to reduce prostaglandin E1-mediated elevations in [3H]cyclic AMP levels with a KD value of 93 nM, thus differentiating between two classes of receptors involved in these responses. Carbachol 53-62 5'-nucleotidase, cytosolic II Mus musculus 37-40 2982089-8 1985 These four agonists and bethanecol, which could increase [3H]cyclic GMP levels only 18% as well as acetylcholine, behaved as competitive antagonists in this response to carbachol. Carbachol 169-178 5'-nucleotidase, cytosolic II Mus musculus 68-71 2982089-10 1985 The equilibrium dissociation constants for the partial agonists determined by their inhibition of carbachol in the [3H] cyclic GMP response also agreed well with their respective EC50 values for mediating the [3H]cyclic AMP response. Carbachol 98-107 5'-nucleotidase, cytosolic II Mus musculus 127-130 2982089-11 1985 Thus, the partial agonists bound to the same receptors at which carbachol mediated [3H]cyclic GMP formation, but with KD values about the same as their respective EC50 values for inhibition of prostaglandin E1-mediated [3H]cyclic AMP increases. Carbachol 64-73 5'-nucleotidase, cytosolic II Mus musculus 94-97 6148690-7 1984 A normal [3H]cyclic GMP response to bradykinin and histamine was demonstrated to be present in cells that had lost the [3H]cyclic GMP response to carbachol. Carbachol 146-155 5'-nucleotidase, cytosolic II Mus musculus 130-133 6184589-4 1982 The phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine (MIX) enhanced the effects of carbachol on both c-GMP accumulation and amylase release. Carbachol 91-100 5'-nucleotidase, cytosolic II Mus musculus 111-114 6331450-1 1984 In neuroblastoma N1E 115 cells, carbachol, histamine and PGE1 elevated cyclic GMP content and, induced the efflux of preloaded 45Ca2+, the release of membrane-bound Ca2+ measured by fluorescent CTC, and the increase in [Ca2+]i as measured by Quin 2 fluorescence. Carbachol 32-41 5'-nucleotidase, cytosolic II Mus musculus 78-81 6289369-5 1982 Epinephrine and carbachol increased plasma cyclic AMP and cyclic GMP levels, respectively, in both C57BL and DBA mice. Carbachol 16-25 5'-nucleotidase, cytosolic II Mus musculus 65-68 6124857-2 1982 In the absence of extracellular sodium isoproterenol-stimulated c-GMP and c-AMP levels were significantly reduced; carbachol-stimulated c-GMP levels were not affected. Carbachol 115-124 5'-nucleotidase, cytosolic II Mus musculus 138-141 6109003-5 1980 Carbamylcholine-, ionophore X-537A-, and sodium azide-induced cyclic GMP formation increased with time in culture to a maximum of 13-, 9-, and 2.5-fold above basal, respectively. Carbachol 0-15 5'-nucleotidase, cytosolic II Mus musculus 69-72 31192-7 1978 N-Methylhydroxylamine also blocked the increases of cyclic GMP levels by carbachol, prostaglandin E1 and N-methyl-N"-nitro-N-nitrosoguanidine in neuroblastoma N1E 115 cells. Carbachol 73-82 5'-nucleotidase, cytosolic II Mus musculus 59-62 217365-4 1978 The assay was used to study the time course of the cyclic GMP changes that occur after stimulation of neuroblastoma cells with carbamoylcholine and the dependence of the cyclic GMP changes on the carbamoylcholine concentration. Carbachol 127-143 5'-nucleotidase, cytosolic II Mus musculus 58-61 217365-4 1978 The assay was used to study the time course of the cyclic GMP changes that occur after stimulation of neuroblastoma cells with carbamoylcholine and the dependence of the cyclic GMP changes on the carbamoylcholine concentration. Carbachol 196-212 5'-nucleotidase, cytosolic II Mus musculus 177-180 202611-8 1978 This defect in beige mice could be corrected by chronic administration of carbamyl choline (t((1/2)) = 3.5 h), a cholinergic agonist which raises intracellular cyclic GMP levels. Carbachol 74-90 5'-nucleotidase, cytosolic II Mus musculus 167-170 19825-7 1977 Cyclic GMP levels were increased by carbachol, acetylcholine, and the phosphodiesterase inhibitor, aminophylline, but not by DSCG, or beta-adrenergic agonists. Carbachol 36-45 5'-nucleotidase, cytosolic II Mus musculus 7-10 11181421-12 2001 Carbachol and Tg produced further increases in calcium/GTP-induced tone and, in both cases, this additional tone was relaxed by NO and 8-Br-cyclic GMP. Carbachol 0-9 5'-nucleotidase, cytosolic II Mus musculus 147-150 4115-8 1976 Conversely, carbamylcholine rapidly increased lymphocyte cyclic GMP but was not mitogenic. Carbachol 12-27 5'-nucleotidase, cytosolic II Mus musculus 64-67