PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7889278-3	1994	In this study we have examined the effects of the specific PKC inhibitors Ro31-8220 and Ro31-7549 and the non-specific inhibitor H7 on carbachol-, 5-hydroxytryptamine (5-HT)- and 4 beta-phorbol dibutyrate (4 beta-PDBu)-induced contractions in large and small bronchioles.	Carbachol	135-144	protein kinase C, gamma	Rattus norvegicus	59-62	
10651876-5	2000	Both Ca2+ and PKC responses were observed within seconds following KCl or carbachol application, and were reversible upon stimulus withdrawal.	Carbachol	74-83	protein kinase C, gamma	Rattus norvegicus	14-17	
7889278-19	1994	These results suggest that there is a significant PKC involvement in constriction of bronchioles to carbachol and 5-HT, and that the proportion of the contractile response that can be attributed to PKC is greater in smaller than larger bronchioles.	Carbachol	100-109	protein kinase C, gamma	Rattus norvegicus	50-53	
1988650-0	1991	Protein kinase C translocation in rat stomach fundus: effects of serotonin, carbamylcholine and phorbol dibutyrate.	Carbachol	76-91	protein kinase C, gamma	Rattus norvegicus	0-16	
8479283-8	1993	Stimulation of mAChRs by the cholinergic agonist carbachol resulted in a pronounced increase in the intensity of 36G9 immunoreactivity, which may suggest that the mAChRs are functionally linked to the colocalized PKC gamma.	Carbachol	49-58	protein kinase C, gamma	Rattus norvegicus	213-222	
1988650-8	1991	However, PDBu (10 nM-1 microM) and carbamylcholine (0.1-10 microM) significantly increased membrane-bound PKC activity.	Carbachol	35-50	protein kinase C, gamma	Rattus norvegicus	106-109	
1988650-9	1991	These results: 1) demonstrate that translocation of PKC occurred in rat stomach fundus in response to some, but not all, contractile agonists; 2) are consistent with the possibility that contraction of rat stomach fundus by carbamylcholine and PDBu may be related to increased membrane-bound PKC activity; and 3) indicate that serotonin-induced contraction, although potently blocked by staurosporine, did not result from PKC translocation in the rat stomach fundus.	Carbachol	224-239	protein kinase C, gamma	Rattus norvegicus	52-55	
1988650-9	1991	These results: 1) demonstrate that translocation of PKC occurred in rat stomach fundus in response to some, but not all, contractile agonists; 2) are consistent with the possibility that contraction of rat stomach fundus by carbamylcholine and PDBu may be related to increased membrane-bound PKC activity; and 3) indicate that serotonin-induced contraction, although potently blocked by staurosporine, did not result from PKC translocation in the rat stomach fundus.	Carbachol	224-239	protein kinase C, gamma	Rattus norvegicus	292-295	
1988650-9	1991	These results: 1) demonstrate that translocation of PKC occurred in rat stomach fundus in response to some, but not all, contractile agonists; 2) are consistent with the possibility that contraction of rat stomach fundus by carbamylcholine and PDBu may be related to increased membrane-bound PKC activity; and 3) indicate that serotonin-induced contraction, although potently blocked by staurosporine, did not result from PKC translocation in the rat stomach fundus.	Carbachol	224-239	protein kinase C, gamma	Rattus norvegicus	292-295	
1688390-1	1990	Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion.	Carbachol	149-164	protein kinase C, gamma	Rattus norvegicus	84-100	
19673741-4	2009	The cholinergic agonist carbachol has been shown to induce axonal outgrowth through intracellular calcium mobilization, protein kinase C (PKC) activation, and ERK1/2 phosphorylation.	Carbachol	24-33	protein kinase C, gamma	Rattus norvegicus	120-136	
19673741-4	2009	The cholinergic agonist carbachol has been shown to induce axonal outgrowth through intracellular calcium mobilization, protein kinase C (PKC) activation, and ERK1/2 phosphorylation.	Carbachol	24-33	protein kinase C, gamma	Rattus norvegicus	138-141	
19673741-13	2009	CONCLUSIONS: Ethanol inhibited carbachol-induced neurite outgrowth by inhibiting PKC and ERK1/2 activation.	Carbachol	31-40	protein kinase C, gamma	Rattus norvegicus	81-84	
11679428-9	2001	Stringent Ca(2+) depletion by removal of extracellular Ca(2+) and inclusion of BAPTA/AM allowed for increased cAMP production in response to CCh and CCK; PKC inhibitors and PKC downregulation prevented this stimulation.	Carbachol	141-144	protein kinase C, gamma	Rattus norvegicus	154-157	
20961851-6	2010	Activation of the cells with carbachol increased the phosphorylation of TRPC6, an effect that was prevented by the inhibition of PKC.	Carbachol	29-38	protein kinase C, gamma	Rattus norvegicus	129-132	
19190235-8	2009	These data suggest an involvement of Ca(2+), PKC, and ERK1/2 in carbachol-induced axonal growth.	Carbachol	64-73	protein kinase C, gamma	Rattus norvegicus	45-48	
19190235-9	2009	Carbachol indeed increased the release of Ca(2+) from intracellular stores and induced PKC and ERK1/2 activation.	Carbachol	0-9	protein kinase C, gamma	Rattus norvegicus	87-90	
19190235-10	2009	Additional experiments showed that PKC, but not Ca(2+), is involved in carbachol-induced ERK1/2 activation.	Carbachol	71-80	protein kinase C, gamma	Rattus norvegicus	35-38	
17320950-10	2007	PMA also reduced the Ca2+ response of intact RINm5F cells stimulated with carbachol and EGF, two agonists that use different receptor types to activate phospholipase C. These results suggest the existence of a negative feedback mechanism involving two components of the Ca2+ signalling cascade, whereby activated PKC dampens IP3R-3 activity.	Carbachol	74-83	protein kinase C, gamma	Rattus norvegicus	313-316	
11679428-6	2001	The effects of phorbol ester, CCh, and CCK were inhibited by as much as 75% by the PKC inhibitors GF 109203X and Ro-32-0432 and after PKC downregulation.	Carbachol	30-33	protein kinase C, gamma	Rattus norvegicus	83-86	
11679428-6	2001	The effects of phorbol ester, CCh, and CCK were inhibited by as much as 75% by the PKC inhibitors GF 109203X and Ro-32-0432 and after PKC downregulation.	Carbachol	30-33	protein kinase C, gamma	Rattus norvegicus	134-137