PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12598604-4 2003 Activation of muscarinic acetylcholine receptors (mAChRs) with carbachol produced an enhancement of GABA(A) receptor currents in acutely dissociated cells after a short treatment with insulin. Carbachol 63-72 insulin Homo sapiens 184-191 15855345-0 2005 Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets: role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia. Carbachol 40-49 insulin Homo sapiens 59-66 15855345-3 2005 At concentrations encompassing therapeutically relevant levels, olanzapine and clozapine reduced insulin secretion stimulated by 10 micromol/l carbachol plus 7 mmol/l glucose. Carbachol 143-152 insulin Homo sapiens 97-104 15855345-4 2005 This inhibition of insulin secretion was paralleled by significant reductions in carbachol-potentiated inositol phosphate accumulation. Carbachol 81-90 insulin Homo sapiens 19-26 12609749-7 2003 High concentrations of IAPP, however, inhibited insulin release stimulated by glucose (10 and 16.7 mM), IBMX, carbachol and L-arginine. Carbachol 110-119 insulin Homo sapiens 48-55 15242775-5 2004 Insulin, a major survival factor in many cells, strongly increased phosphorylation of Akt, which was completely blocked by carbachol. Carbachol 123-132 insulin Homo sapiens 0-7 15242775-7 2004 In parallel with these observations, carbachol attenuated insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1, an effect eliminated by orthovanadate. Carbachol 37-46 insulin Homo sapiens 58-65 15242775-7 2004 In parallel with these observations, carbachol attenuated insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1, an effect eliminated by orthovanadate. Carbachol 37-46 insulin Homo sapiens 105-112 12598604-5 2003 Inhibiting phosphoinositide-3 kinase (PI3K), a downstream target of insulin signaling, eliminated this effect as well as the carbachol-induced enhancement of GABAergic miniature IPSC amplitudes in PFC slices. Carbachol 125-134 insulin Homo sapiens 68-75 12011082-0 2002 Effects of glucose, exogenous insulin, and carbachol on C-peptide and insulin secretion from isolated perifused rat islets. Carbachol 43-52 insulin Homo sapiens 70-77 10050013-2 1999 We have investigated, with a combined in vitro and in vivo approach, the influence on insulin and glucagon release stimulated by the cholinergic, muscarinic agonist carbachol of different NO modulators, i.e. the nitric oxide synthase (NOS) inhibitors NG-nitro-L-arginine methyl ester (L-NAME), NG-monomethyl-L-arginine (L-NMMA) and 7-nitroindazole as well as the intracellular NO donor hydroxylamine. Carbachol 165-174 insulin Homo sapiens 86-93 11408264-5 2001 Basolateral, but not apical, addition of insulin inhibited carbachol- and thapsigargin-induced chloride secretion in a time- and concentration-dependent fashion. Carbachol 59-68 insulin Homo sapiens 41-48 10965900-3 2000 Wortmannin amplified insulin release induced by the combination of 6-8 mM glucose plus 1 microM carbachol; however, it had no effect on phorbol ester- or alpha-ketoisocaproate-induced insulin secretion. Carbachol 96-105 insulin Homo sapiens 21-28 10050013-4 1999 At basal glucose (7 mM) carbachol dose-dependently stimulated insulin release from isolated islets with a half-maximal response at approximately 1 microM of the agonist. Carbachol 24-33 insulin Homo sapiens 62-69 10050013-7 1999 Carbachol-stimulated islets displayed an increased insulin release and a suppressed glucagon release in the presence of L-NAME, L-NMMA or 7-nitroindazole. Carbachol 0-9 insulin Homo sapiens 51-58 10050013-9 1999 The intracellular NO donor hydroxylamine dose-dependently inhibited carbachol-induced insulin release but stimulated glucagon release only at a low concentration (3 microM). Carbachol 68-77 insulin Homo sapiens 86-93 10050013-11 1999 In islets depolarized with 30 mM K+ in the presence of the KATP channel opener diazoxide, NOS inhibition by 5 mM L-NAME still markedly potentiated carbachol-induced insulin release (although less so than in normal islets) and suppressed glucagon release. Carbachol 147-156 insulin Homo sapiens 165-172 9690052-12 1998 Parasympathetic cholinergic influence was studied using 500 mumol/l carbamylcholine, which increased insulin secretion. Carbachol 68-83 insulin Homo sapiens 101-108 9877233-8 1998 Further, in the presence of diazoxide, a potent K+ ATP-channel opener, plus a depolarizing concentration of K+ the NOS-inhibitor L-NAME still markedly potentiated carbachol-induced insulin release and inhibited glucagon release. Carbachol 163-172 insulin Homo sapiens 181-188 9877233-12 1998 Furthermore, a series of perifusion experiments revealed that hydroxylamine greatly inhibited carbachol-induced insulin release without affecting the 45Ca2+ -efflux pattern. Carbachol 94-103 insulin Homo sapiens 112-119 9877233-13 1998 In summary, our results suggest that the inhibitory effect of NO on carbachol-induced insulin release is not to any significant extent exerted on the IP3-Ca2+ messenger system but rather through S-nitrosylation of critical thiol-residues in protein kinase C and/or other secretion-regulatory thiol groups. Carbachol 68-77 insulin Homo sapiens 86-93 8897815-3 1996 Stimulation of insulin release evoked by glucose, phospholipase C activation with carbachol, and protein kinase C activation with phorbol ester were obtained by SIN-1, whereas the response to adenylyl cyclase activation or K(+)-induced depolarization was not affected. Carbachol 82-91 insulin Homo sapiens 15-22 9209957-9 1997 With addition of 100 microM carbamylcholine, the dissociation was expressed as normal secretion of insulin and hypersecretion of IAPP. Carbachol 28-43 insulin Homo sapiens 99-106 7947736-9 1994 RHC-80267 inhibits glucose- and carbachol-induced insulin release from intact islets in a dose-dependent manner that parallels its inhibition of diacylglycerol lipase activity. Carbachol 32-41 insulin Homo sapiens 50-57 8843732-5 1996 However, stimulation of mouse islets with the protein kinase C (PKC) activator tetradecanoyl phorbol acetate (TPA) or the muscarinic agonist carbachol, which significantly activates an isozyme of PLC distinct from that activated by high glucose, induces a rising and sustained second-phase insulin secretory response. Carbachol 141-150 insulin Homo sapiens 290-297 8596502-2 1996 Compared with responses observed from control islets incubated for 3.5 hours with 5.6 mmol/L glucose alone, prior exposure to 10 mmol/L glucose, 20 mmol/L glucose, or 10 micromol/L carbachol reduced peak second-phase insulin release rates to a subsequent 20-mmol/L glucose stimulus by 63%, 81%, or 70%, respectively. Carbachol 181-190 insulin Homo sapiens 217-224 8596502-5 1996 Carbachol (10 micromol/L) preexposure also abolished the subsequent insulin secretory and 3H-inositol efflux responses to 8 mmol/L glucose plus 10 micromol/L carbachol. Carbachol 0-9 insulin Homo sapiens 68-75 8596502-5 1996 Carbachol (10 micromol/L) preexposure also abolished the subsequent insulin secretory and 3H-inositol efflux responses to 8 mmol/L glucose plus 10 micromol/L carbachol. Carbachol 158-167 insulin Homo sapiens 68-75 7887929-5 1995 Insulin secretagogues (28 mM glucose + 0.5 mM carbachol) caused a rapid and transient increase in PtdIns(3,4,5)P3 levels which peaked at 2-5 min, corresponding to peak early phase insulin release. Carbachol 46-55 insulin Homo sapiens 0-7 7887929-5 1995 Insulin secretagogues (28 mM glucose + 0.5 mM carbachol) caused a rapid and transient increase in PtdIns(3,4,5)P3 levels which peaked at 2-5 min, corresponding to peak early phase insulin release. Carbachol 46-55 insulin Homo sapiens 180-187 4365701-2 1973 The maximal amount of cyclic GMP, achieved within 2 min after addition of insulin or carbamylcholine, falls rapidly for insulin and much more slowly for carbamylcholine. Carbachol 85-100 insulin Homo sapiens 120-127 8218298-2 1993 Insulin secretagogues, such as glucose and the muscarinic agonist carbachol, stimulate arachidonic acid accumulation, although the mechanisms involved are controversial: carbachol is believed to stimulate phospholipase A2, while glucose-induced arachidonic acid release is the result of diacylglycerol hydrolysis [Konrad, R. J., et al. Carbachol 66-75 insulin Homo sapiens 0-7 8218298-2 1993 Insulin secretagogues, such as glucose and the muscarinic agonist carbachol, stimulate arachidonic acid accumulation, although the mechanisms involved are controversial: carbachol is believed to stimulate phospholipase A2, while glucose-induced arachidonic acid release is the result of diacylglycerol hydrolysis [Konrad, R. J., et al. Carbachol 170-179 insulin Homo sapiens 0-7 8249680-11 1993 In a carbachol-induced stress model, insulin is not required for a putatively neural regulation of an increase in systemic glucose uptake but a "permissive" effect of insulin is essential. Carbachol 5-14 insulin Homo sapiens 37-44 8249680-11 1993 In a carbachol-induced stress model, insulin is not required for a putatively neural regulation of an increase in systemic glucose uptake but a "permissive" effect of insulin is essential. Carbachol 5-14 insulin Homo sapiens 167-174 1876601-6 1991 At the same concentration, however, IAPP significantly (p less than 0.05) inhibited carbachol-stimulated (10(-7) M) release of insulin by 30%, and CGRP significantly inhibited carbachol-stimulated release of insulin by 33% when compared with the control group. Carbachol 84-93 insulin Homo sapiens 127-134 1876601-6 1991 At the same concentration, however, IAPP significantly (p less than 0.05) inhibited carbachol-stimulated (10(-7) M) release of insulin by 30%, and CGRP significantly inhibited carbachol-stimulated release of insulin by 33% when compared with the control group. Carbachol 176-185 insulin Homo sapiens 208-215 2452098-1 1988 The increased insulin release induced by carbamoylcholine (CbCh) in pancreatic islets requires the presence of extracellular Ca2+. Carbachol 41-57 insulin Homo sapiens 14-21 2452098-1 1988 The increased insulin release induced by carbamoylcholine (CbCh) in pancreatic islets requires the presence of extracellular Ca2+. Carbachol 59-63 insulin Homo sapiens 14-21 2439077-1 1987 Glucose, forskolin, IBMX and carbachol all stimulated insulin release from freshly obtained human insulinoma cells. Carbachol 29-38 insulin Homo sapiens 54-61 2439077-3 1987 On the other hand, of all the insulin secretagogues examined, only carbachol stimulated the formation of 3H-inositol trisphosphate in these cells. Carbachol 67-76 insulin Homo sapiens 30-37 4365701-2 1973 The maximal amount of cyclic GMP, achieved within 2 min after addition of insulin or carbamylcholine, falls rapidly for insulin and much more slowly for carbamylcholine. Carbachol 153-168 insulin Homo sapiens 74-81