PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3495533-2 1987 PMA, carbachol, and EGF all stimulated rapid accumulation of mRNA for the proto-oncogenes c-fos and c-myc in the normal cells; in the protein kinase C-deficient cells, carbachol and EGF, but not PMA, retained this effect, which was not mimicked by the calcium ionophore A23187. Carbachol 5-14 epidermal growth factor Homo sapiens 182-185 3495533-2 1987 PMA, carbachol, and EGF all stimulated rapid accumulation of mRNA for the proto-oncogenes c-fos and c-myc in the normal cells; in the protein kinase C-deficient cells, carbachol and EGF, but not PMA, retained this effect, which was not mimicked by the calcium ionophore A23187. Carbachol 168-177 epidermal growth factor Homo sapiens 20-23 11003583-6 2000 Inhibition of the carbachol response by EGF was not altered by phorbol ester-induced downregulation of protein kinase C (PKC) but was enhanced upon PKC activation by a diacylglycerol analog. Carbachol 18-27 epidermal growth factor Homo sapiens 40-43 11003583-1 2000 The effects of epidermal growth factor (EGF) on intracellular calcium ([Ca(2+)](i)) responses to the muscarinic agonist carbachol were studied in a human salivary cell line (HSY). Carbachol 120-129 epidermal growth factor Homo sapiens 15-38 11003583-1 2000 The effects of epidermal growth factor (EGF) on intracellular calcium ([Ca(2+)](i)) responses to the muscarinic agonist carbachol were studied in a human salivary cell line (HSY). Carbachol 120-129 epidermal growth factor Homo sapiens 40-43 11003583-2 2000 Carbachol (10(-4) M)-stimulated [Ca(2+)](i) mobilization was inhibited by 40% after 48-h treatment with 5 x 10(-10) M EGF. Carbachol 0-9 epidermal growth factor Homo sapiens 118-121 11003583-3 2000 EGF also reduced carbachol-induced [Ca(2+)](i) in Ca(2+)-free medium and Ca(2+) influx following repletion of extracellular Ca(2+). Carbachol 17-26 epidermal growth factor Homo sapiens 0-3 32652816-3 2020 EGFr TKIs (such as afatinib, erlotinib, and osimertinib) reversed the acute inhibitory effect of EGF on chloride secretion induced by carbachol (CCh) across T84 human colonic epithelial cells, which correlated with the diarrhea-inducing effect of each agent clinically. Carbachol 134-143 epidermal growth factor Homo sapiens 0-3 32652816-3 2020 EGFr TKIs (such as afatinib, erlotinib, and osimertinib) reversed the acute inhibitory effect of EGF on chloride secretion induced by carbachol (CCh) across T84 human colonic epithelial cells, which correlated with the diarrhea-inducing effect of each agent clinically. Carbachol 145-148 epidermal growth factor Homo sapiens 0-3 32652816-6 2020 EGFr TKIs also suppressed phosphorylation of extracellular signal-regulated kinase (Erk)1/2 in response to EGF, whereas they had weaker effects on CCh-induced Erk1/2 phosphorylation. Carbachol 147-150 epidermal growth factor Homo sapiens 0-3 32652816-7 2020 In human EDMs, EGF potentiated ion transport induced by CCh, whereas afatinib reversed this effect. Carbachol 56-59 epidermal growth factor Homo sapiens 15-18 11003583-7 2000 Phosphorylation of mitogen-activated protein kinase (MAP kinase) and inhibition of the carbachol response by EGF were both blocked by the MAP kinase pathway inhibitor PD-98059. Carbachol 87-96 epidermal growth factor Homo sapiens 109-112 11003583-8 2000 The results suggest that EGF decreases carbachol-induced Ca(2+) release from internal stores and also exerts a direct inhibitory action on Ca(2+) influx. Carbachol 39-48 epidermal growth factor Homo sapiens 25-28 11003583-9 2000 A decline in muscarinic receptor density may contribute to EGF inhibition of carbachol responsiveness. Carbachol 77-86 epidermal growth factor Homo sapiens 59-62 10801833-1 2000 Epidermal growth factor (EGF) inhibits carbachol-induced chloride secretion in T(84) colonic epithelial cells and has been shown to activate phosphatidylinositol (PI) 3-kinase, leading to inhibition of a basolateral potassium conductance. Carbachol 39-48 epidermal growth factor Homo sapiens 0-23 10801833-1 2000 Epidermal growth factor (EGF) inhibits carbachol-induced chloride secretion in T(84) colonic epithelial cells and has been shown to activate phosphatidylinositol (PI) 3-kinase, leading to inhibition of a basolateral potassium conductance. Carbachol 39-48 epidermal growth factor Homo sapiens 25-28 10801833-9 2000 Antisense oligonucleotides against PKCepsilon decreased PKCepsilon mass and prevented the inhibitory effect of EGF on carbachol-induced (86)Rb(+) efflux. Carbachol 118-127 epidermal growth factor Homo sapiens 111-114 10801833-10 2000 Thus, the inhibitory effect of EGF on carbachol-induced chloride secretion involves the activation of PKCepsilon mediated by PI 3-kinase. Carbachol 38-47 epidermal growth factor Homo sapiens 31-34 10559227-7 1999 Further studies revealed that, while both EGF (100 ng/ml) and CCh (100 microM) stimulated phosphorylation of the EGFR, only EGF stimulated phosphorylation of ErbB2, and neither stimulated ErbB3 phosphorylation. Carbachol 62-65 epidermal growth factor Homo sapiens 113-116 10559227-10 1999 Differential dimerization with other ErbB family members may underlie the ability of the EGFR to propagate diverse inhibitory signals in response to activation by EGF or transactivation by CCh. Carbachol 189-192 epidermal growth factor Homo sapiens 89-92 10348664-8 1999 In contrast to the results with carbachol, H2O2 potentiated EGF-induced tyrosine phosphorylation. Carbachol 32-41 epidermal growth factor Homo sapiens 60-63 10049786-3 1999 Activation of muscarinic receptors with carbachol was found to inhibit EGF-induced signaling, including tyrosine phosphorylation of the adaptor protein Cbl and of the EGF receptor, and complex formation between Shc proteins and the EGF receptor and Grb2. Carbachol 40-49 epidermal growth factor Homo sapiens 71-74 8843722-2 1996 Basolateral EGF inhibited Cl- secretion induced by carbachol or thapsigargin, without blocking the rise in intracellular Ca2+. Carbachol 51-60 epidermal growth factor Homo sapiens 12-15 1330669-4 1992 EGF, isoproterenol and NECA have no effect on basal levels of inositol phosphates (InsPs) in human RPE cells, but EGF specifically elevates the carbachol-induced stimulation of InsPs. Carbachol 144-153 epidermal growth factor Homo sapiens 0-3 1330669-4 1992 EGF, isoproterenol and NECA have no effect on basal levels of inositol phosphates (InsPs) in human RPE cells, but EGF specifically elevates the carbachol-induced stimulation of InsPs. Carbachol 144-153 epidermal growth factor Homo sapiens 114-117