PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25279100-6 2012 Intracellular calcium level measurements in transfected cells revealed a more intensive carbachol induced increase of calcium concentration in HEK 293 cells expressing TRPC6P112Q versus the cells expressing wild-type TRPC6. Carbachol 88-97 transient receptor potential cation channel subfamily C member 6 Homo sapiens 168-173 23529130-2 2013 Induction of currents (ICCh) in TRPC6-expressing HEK293 cells by a muscarinic agonist carbachol (CCh; 100 mum) was strongly attenuated by a CaMKII-specific peptide, autocamtide-2-related inhibitory peptide (AIP; 10 mum). Carbachol 86-95 transient receptor potential cation channel subfamily C member 6 Homo sapiens 32-37 27979597-5 2017 BTP2 inhibited carbachol-activated TRPC3 and TRPC6 channel activities in HEK293 cells. Carbachol 15-24 transient receptor potential cation channel subfamily C member 6 Homo sapiens 45-50 23529130-2 2013 Induction of currents (ICCh) in TRPC6-expressing HEK293 cells by a muscarinic agonist carbachol (CCh; 100 mum) was strongly attenuated by a CaMKII-specific peptide, autocamtide-2-related inhibitory peptide (AIP; 10 mum). Carbachol 24-27 transient receptor potential cation channel subfamily C member 6 Homo sapiens 32-37 15579537-2 2004 With nystatin-perforated recording, the magnitude and time courses of activation and inactivation of carbachol (CCh; 100 microM)-activated TRPC6 currents (I(TRPC6)) were enhanced and accelerated, respectively, by extracellular Ca2+ (Ca2+(o)) whether it was continuously present or applied after receptor stimulation. Carbachol 101-110 transient receptor potential cation channel subfamily C member 6 Homo sapiens 139-144 19443836-4 2009 In HEK293 cells expressing TRPC6, application of mechanical stimuli (hypotonicity, shear, 2,4,6-trinitrophenol) caused, albeit not effective by themselves, a prominent potentiation of cationic currents (I(TRPC6)) induced by a muscarinic receptor agonist carbachol. Carbachol 254-263 transient receptor potential cation channel subfamily C member 6 Homo sapiens 27-32 19443836-7 2009 Single TRPC6 channel activity evoked by carbachol was also enhanced by a negative pressure added in the patch pipette. Carbachol 40-49 transient receptor potential cation channel subfamily C member 6 Homo sapiens 7-12 19443836-8 2009 Mechanical potentiation of carbachol- or OAG-induced I(TRPC6) was abolished by small interfering RNA knockdown of cytosolic phospholipase A(2) or pharmacological inhibition of omega-hydroxylation of arachidonic acid into 20-HETE (20-hydroxyeicosatetraenoic acid). Carbachol 27-36 transient receptor potential cation channel subfamily C member 6 Homo sapiens 55-60 19332491-5 2009 Specifically, Ca(2+) entry seen after carbachol treatment in cells transiently expressing TRPC1, TRPC3, TRPC5 or TRPC6 was not enhanced by the co-expression of STIM1. Carbachol 38-47 transient receptor potential cation channel subfamily C member 6 Homo sapiens 113-118 21951618-15 2012 In contrast, carbachol-induced TRPC6 channel activity was significantly inhibited (87.3%) by SCE in green fluorescent protein-TRPC6 pcDNA transfected HEK 293 cells. Carbachol 13-22 transient receptor potential cation channel subfamily C member 6 Homo sapiens 31-36 21951618-15 2012 In contrast, carbachol-induced TRPC6 channel activity was significantly inhibited (87.3%) by SCE in green fluorescent protein-TRPC6 pcDNA transfected HEK 293 cells. Carbachol 13-22 transient receptor potential cation channel subfamily C member 6 Homo sapiens 126-131 18617565-2 2008 Cationic currents due to TRPC6 expression were strongly suppressed (by approximately 70%) by a NO donor SNAP (100 microm) whether it was applied prior to muscarinic receptor stimulation with carbachol (CCh; 100 microm) or after G-protein activation with intracellular perfusion of GTPgammaS (100 microm). Carbachol 191-200 transient receptor potential cation channel subfamily C member 6 Homo sapiens 25-30 18617565-2 2008 Cationic currents due to TRPC6 expression were strongly suppressed (by approximately 70%) by a NO donor SNAP (100 microm) whether it was applied prior to muscarinic receptor stimulation with carbachol (CCh; 100 microm) or after G-protein activation with intracellular perfusion of GTPgammaS (100 microm). Carbachol 202-205 transient receptor potential cation channel subfamily C member 6 Homo sapiens 25-30 15579537-2 2004 With nystatin-perforated recording, the magnitude and time courses of activation and inactivation of carbachol (CCh; 100 microM)-activated TRPC6 currents (I(TRPC6)) were enhanced and accelerated, respectively, by extracellular Ca2+ (Ca2+(o)) whether it was continuously present or applied after receptor stimulation. Carbachol 101-110 transient receptor potential cation channel subfamily C member 6 Homo sapiens 157-162 15579537-2 2004 With nystatin-perforated recording, the magnitude and time courses of activation and inactivation of carbachol (CCh; 100 microM)-activated TRPC6 currents (I(TRPC6)) were enhanced and accelerated, respectively, by extracellular Ca2+ (Ca2+(o)) whether it was continuously present or applied after receptor stimulation. Carbachol 112-115 transient receptor potential cation channel subfamily C member 6 Homo sapiens 139-144 15579537-2 2004 With nystatin-perforated recording, the magnitude and time courses of activation and inactivation of carbachol (CCh; 100 microM)-activated TRPC6 currents (I(TRPC6)) were enhanced and accelerated, respectively, by extracellular Ca2+ (Ca2+(o)) whether it was continuously present or applied after receptor stimulation. Carbachol 112-115 transient receptor potential cation channel subfamily C member 6 Homo sapiens 157-162 14662757-7 2004 The carbachol concentration at which TRPC6 externalization occurred was lower than the concentration required to activate TRPC6. Carbachol 4-13 transient receptor potential cation channel subfamily C member 6 Homo sapiens 37-42 14662757-7 2004 The carbachol concentration at which TRPC6 externalization occurred was lower than the concentration required to activate TRPC6. Carbachol 4-13 transient receptor potential cation channel subfamily C member 6 Homo sapiens 122-127 15023993-2 2004 Whole cell membrane currents with distinctive inward and outward rectification were activated by carbachol (CCh) in TRPC6-expressing cells, but not in lacZ-transfected controls. Carbachol 97-106 transient receptor potential cation channel subfamily C member 6 Homo sapiens 116-121 15023993-2 2004 Whole cell membrane currents with distinctive inward and outward rectification were activated by carbachol (CCh) in TRPC6-expressing cells, but not in lacZ-transfected controls. Carbachol 108-111 transient receptor potential cation channel subfamily C member 6 Homo sapiens 116-121 15023993-9 2004 Surprisingly, concentrations of CCh that produced little or no response in the absence of OAG, produced increases in TRPC6 currents in the presence of OAG that were larger than the sum of either agent alone. Carbachol 32-35 transient receptor potential cation channel subfamily C member 6 Homo sapiens 117-122 15023993-12 2004 This synergy may explain, at least in part, the steep dose-response relationship observed for CCh-induced TRPC6 currents expressed in HEK cells. Carbachol 94-97 transient receptor potential cation channel subfamily C member 6 Homo sapiens 106-111