PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16899552-1	2007	EGF inhibits carbachol-induced chloride secretion by regulating a basolateral potassium channel via phosphatidylinositol 3-kinase (PI 3-kinase) and PKCepsilon activation.	Carbachol	13-22	protein kinase C epsilon	Homo sapiens	148-158	
20658540-6	2011	Carbachol stimulated phosphorylation of PKC isoforms and translocation of PKCdelta and PKCepsilon to membranes within 5 min.	Carbachol	0-9	protein kinase C epsilon	Homo sapiens	87-97	
20658540-8	2011	Significant participation of PKCepsilon in the carbachol-induced gain of GLUT4myc at the surface of C2C12 myotubes was further supported through siRNA-mediated PKCepsilon protein knockdown.	Carbachol	47-56	protein kinase C epsilon	Homo sapiens	29-39	
12372816-7	2002	The PKCepsilon-selective agonist carbachol (100 microM) induced prolonged stimulation of endocytosis devoid of an inhibitory phase.	Carbachol	33-42	protein kinase C epsilon	Homo sapiens	4-14	
15358594-8	2005	The pharmacological agonists phorbol 12-myristate 13-acetate and carbachol also led to the translocation of PKC-epsilon.	Carbachol	65-74	protein kinase C epsilon	Homo sapiens	108-119	
15358594-11	2005	Consistent with this observation, carbachol induces the translocation of PKC-epsilon to proximity with MARCKS at the lateral membrane.	Carbachol	34-43	protein kinase C epsilon	Homo sapiens	73-84	
15233804-7	2004	The response to carbachol is instead completely blocked in PKCepsilon-deficient cells suggesting the importance of PKCepsilon in coupling cholinergic receptors with APP metabolism.	Carbachol	16-25	protein kinase C epsilon	Homo sapiens	59-69	
9151658-8	1997	PKCepsilon was the most responsive to PdBu reaching almost maximal translocation at a PdBu concentration as low as 10(-9) M. The cholinergic agonist, carbachol (10(-5) and 10(-3) M), induced translocation which was transient for PKCdelta, and -mu, but persisted for 10 min for PKCepsilon.	Carbachol	150-159	protein kinase C epsilon	Homo sapiens	0-10	
11443064-11	2001	Carbachol (100 microM) translocated only PKC epsilon and inhibited I(sc) with no effect on TER.	Carbachol	0-9	protein kinase C epsilon	Homo sapiens	41-52	
11460267-7	2001	Additional experiments with PKC alpha- or PKC epsilon-specific compounds indicated that the epsilon isozyme of PKC is primarily involved in MAPK activation by carbachol.	Carbachol	159-168	protein kinase C epsilon	Homo sapiens	42-53	
11233758-5	2000	Carbachol caused an increase in phorbol ester binding and translocation of PKCepsilon, however, these were inhibited only by 100-200 mM ethanol.	Carbachol	0-9	protein kinase C epsilon	Homo sapiens	75-85	
9882625-3	1999	The activation of Erk-1/-2 by carbachol was blocked by the inhibition or down-regulation of protein kinase C (PKC).	Carbachol	30-39	protein kinase C epsilon	Homo sapiens	110-113	
9882625-4	1999	Among the multiple PKC isoforms expressed in SK-N-BE2(C) cells, only PKCepsilon was activated by the treatment of carbachol, and selective down-regulation of PKCepsilon was sufficient to block Erk-1/-2 activation.	Carbachol	114-123	protein kinase C epsilon	Homo sapiens	19-22	
9882625-4	1999	Among the multiple PKC isoforms expressed in SK-N-BE2(C) cells, only PKCepsilon was activated by the treatment of carbachol, and selective down-regulation of PKCepsilon was sufficient to block Erk-1/-2 activation.	Carbachol	114-123	protein kinase C epsilon	Homo sapiens	69-79	
9882625-7	1999	Thus, these results suggest that carbachol-induced activation of PKCepsilon mediates Erk-1/-2 activation by a sequential activation of Ras, Raf and MAP kinase kinase.	Carbachol	33-42	protein kinase C epsilon	Homo sapiens	65-75	
10801833-10	2000	Thus, the inhibitory effect of EGF on carbachol-induced chloride secretion involves the activation of PKCepsilon mediated by PI 3-kinase.	Carbachol	38-47	protein kinase C epsilon	Homo sapiens	102-112	
7935319-9	1994	Thrombin and carbachol cause comparable changes in redistribution of both PKC-alpha and PKC-epsilon.	Carbachol	13-22	protein kinase C epsilon	Homo sapiens	88-99	
8297348-11	1994	These data suggest that PKC-alpha and/or PKC-epsilon play an essential role in the regulation of PMA-enhanced K(+)- and carbachol-evoked NA release in SH-SY5Y cells.	Carbachol	120-129	protein kinase C epsilon	Homo sapiens	41-52