PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17005856-3 2006 To better understand the synaptic mechanisms involved in gamma oscillogenesis, we recorded action potentials and synaptic currents in distinct types of anatomically identified CA3 neurons during carbachol-induced (20-25 microM) gamma oscillations in rat hippocampal slices. Carbachol 195-204 carbonic anhydrase 3 Rattus norvegicus 176-179 23651161-5 2013 In this study, using in vitro whole-cell patch-clamp recordings in a rat hippocampal slice preparation, we show that hippocampal CA3 pyramidal cells support persistent firing under perfusion of the cholinergic agonist carbachol (10 mum). Carbachol 218-227 carbonic anhydrase 3 Rattus norvegicus 129-132 22466505-2 2012 We found that carbachol-induced oscillations in rat CA3 have biphasic phase-response curves, consistent with the ability to couple with oscillations in afferent projections. Carbachol 14-23 carbonic anhydrase 3 Rattus norvegicus 52-55 20505129-0 2010 Carbachol-induced long-term synaptic depression is enhanced during senescence at hippocampal CA3-CA1 synapses. Carbachol 0-9 carbonic anhydrase 3 Rattus norvegicus 93-100 18306282-6 2008 We showed that carbachol activation of the MS-DB generated large theta oscillations in the CA1 and CA3 regions of the hippocampus. Carbachol 15-24 carbonic anhydrase 3 Rattus norvegicus 99-102 17964734-4 2007 In region CA1 of the rat (Sprague Dawley) hippocampus, the cholinergic agonist carbachol (CCh) suppresses transmission in stratum radiatum (SR), at synapses of the Schaffer collateral projection from CA3, while having lesser effects in stratum lacunosum-moleculare (SLM), the perforant path projection from entorhinal cortex (Hasselmo and Schnell, 1994). Carbachol 79-88 carbonic anhydrase 3 Rattus norvegicus 200-203 17964734-4 2007 In region CA1 of the rat (Sprague Dawley) hippocampus, the cholinergic agonist carbachol (CCh) suppresses transmission in stratum radiatum (SR), at synapses of the Schaffer collateral projection from CA3, while having lesser effects in stratum lacunosum-moleculare (SLM), the perforant path projection from entorhinal cortex (Hasselmo and Schnell, 1994). Carbachol 90-93 carbonic anhydrase 3 Rattus norvegicus 200-203 11069606-0 2000 A model of gamma-frequency network oscillations induced in the rat CA3 region by carbachol in vitro. Carbachol 81-90 carbonic anhydrase 3 Rattus norvegicus 67-70 11353015-18 2001 In conclusion, st. radiatum interneurons of CA3 hippocampal region represent a class of nonpyramidal cells with action potentials followed by an AHP of relatively short duration, partially generated by apamin and carbachol-sensitive conductances involved in the regulation of the cell firing rate. Carbachol 213-222 carbonic anhydrase 3 Rattus norvegicus 44-47 11769308-3 2001 In a network model of area CA3, the time scale for CCH-delta corresponded to the decay constant of the gating variable of the calcium-dependent potassium (K-AHP) current, that of CCH-theta to an intrinsic subthreshold membrane potential oscillation of the pyramidal cells, and that of CCH-gamma to the decay constant of GABAergic inhibitory synaptic potentials onto the pyramidal cells. Carbachol 51-54 carbonic anhydrase 3 Rattus norvegicus 27-30 11769308-3 2001 In a network model of area CA3, the time scale for CCH-delta corresponded to the decay constant of the gating variable of the calcium-dependent potassium (K-AHP) current, that of CCH-theta to an intrinsic subthreshold membrane potential oscillation of the pyramidal cells, and that of CCH-gamma to the decay constant of GABAergic inhibitory synaptic potentials onto the pyramidal cells. Carbachol 179-182 carbonic anhydrase 3 Rattus norvegicus 27-30 11769308-3 2001 In a network model of area CA3, the time scale for CCH-delta corresponded to the decay constant of the gating variable of the calcium-dependent potassium (K-AHP) current, that of CCH-theta to an intrinsic subthreshold membrane potential oscillation of the pyramidal cells, and that of CCH-gamma to the decay constant of GABAergic inhibitory synaptic potentials onto the pyramidal cells. Carbachol 179-182 carbonic anhydrase 3 Rattus norvegicus 27-30 10791841-1 2000 Carbachol, a muscarinic receptor agonist, produced three distinct spontaneous oscillations in the CA3 region of rat hippocampal slices. Carbachol 0-9 carbonic anhydrase 3 Rattus norvegicus 98-101 10791841-2 2000 Carbachol concentrations in the 4-13 microM range produced regular synchronized CA3 discharges at 0.5-2 Hz (carbachol-delta). Carbachol 0-9 carbonic anhydrase 3 Rattus norvegicus 80-83 10791841-2 2000 Carbachol concentrations in the 4-13 microM range produced regular synchronized CA3 discharges at 0.5-2 Hz (carbachol-delta). Carbachol 108-117 carbonic anhydrase 3 Rattus norvegicus 80-83 10791841-8 2000 Field and intracellular recordings from CA1 and CA3 pyramidal cells and interneurons during carbachol-induced rhythms revealed that the hippocampal circuitry preserved in the slice was capable of spontaneous activity over the range of frequencies observed in vivo and suggests that the presence of these rhythms could be under neuromodulatory control. Carbachol 92-101 carbonic anhydrase 3 Rattus norvegicus 48-51 9466430-1 1998 We investigated the effects of the cholinergic agonist carbachol (25 microM) on the synaptic potentials recorded extracellularly and intracellularly from the CA3 area of immature hippocampal slices of the rat (postnatal days 10-20). Carbachol 55-64 carbonic anhydrase 3 Rattus norvegicus 158-161 2621591-3 1989 In all impaled CA3 pyramidal neurones, continuous applications of carbachol, a non-hydrolysable cholinergic agonist, induced first a brief non-rhythmic excitation and then periodic bursts of RSA which could persist for several hours. Carbachol 66-75 carbonic anhydrase 3 Rattus norvegicus 15-18 2621591-8 1989 Analyses of simultaneous recordings from pairs of neurones, or a neurone and a glial cell, or a neurone and the extracellular field, indicated that carbachol-induced RSA was synchronous in a large population of CA3 pyramidal neurones. Carbachol 148-157 carbonic anhydrase 3 Rattus norvegicus 211-214 2621591-15 1989 Raising extracellular [Ca2+] beyond 7 mM, which should significantly weaken the polysynaptic recurrent excitation among CA3 pyramidal neurones, abolished carbachol-induced RSA. Carbachol 154-163 carbonic anhydrase 3 Rattus norvegicus 120-123 2621591-16 1989 This suggests that the recurrent excitation among CA3 pyramidal neurones is necessary for carbachol-induced RSA in the CA3 area. Carbachol 90-99 carbonic anhydrase 3 Rattus norvegicus 50-53 2621591-16 1989 This suggests that the recurrent excitation among CA3 pyramidal neurones is necessary for carbachol-induced RSA in the CA3 area. Carbachol 90-99 carbonic anhydrase 3 Rattus norvegicus 119-122 3942871-2 1986 Infusions of eserine or carbachol elicited hippocampal theta activity when made in areas containing high levels of cholinergic markers: the stratum oriens and radiatum of the CA1 and CA3, the stratum moleculare and stratum granulosum of the dentate gyrus and the infragranular region of the hilus. Carbachol 24-33 carbonic anhydrase 3 Rattus norvegicus 183-186 9356412-5 1997 In extracellular recordings, a regularly spaced bursting pattern of field potentials was observed in both CA3 and CA1 subfields in the presence of carbachol. Carbachol 147-156 carbonic anhydrase 3 Rattus norvegicus 106-109 9356412-10 1997 In the presence of carbachol, individual CA3 pyramidal cells exhibited a slow, rhythmic intrinsic oscillation that was not blocked by DNQX and that was enhanced by membrane hyperpolarization. Carbachol 19-28 carbonic anhydrase 3 Rattus norvegicus 41-44