PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20573995-7 2010 Surprisingly, we found that knockdown of RGS8 and RGS9, but not other conventional RGS proteins, significantly decreased carbachol-mediated calcium mobilization, whereas only RGS8 knockdown decreased protease-activated receptor-1 (PAR-1)-mediated calcium mobilization. Carbachol 121-130 paired like homeodomain 2 Homo sapiens 41-44 28921504-10 2017 Galpha12 coimmunoprecipitated with M3 receptors, and p115RhoGEF-RGS overexpression inhibited carbachol-mediated induction of SRE-luciferase reporter. Carbachol 93-102 paired like homeodomain 2 Homo sapiens 64-67 28921504-11 2017 p115RhoGEF-RGS overexpression inhibited carbachol-induced activation of Akt, HASMC contraction, and shortening. Carbachol 40-49 paired like homeodomain 2 Homo sapiens 11-14 9874691-5 1999 In control cells expressing alpha1B, alpha2, and beta3 Ca channel subunits and m2 receptors, carbachol (1 microM) inhibited whole-cell currents by approximately 80% compared with only approximately 55% inhibition in cells also expressing exogenous RGS protein. Carbachol 93-102 paired like homeodomain 2 Homo sapiens 248-251 11755214-2 2001 In human astrocytoma 1321N1 cells RGS2 expression was increased by activation of muscarinic receptors coupled to phosphoinositide signaling with carbachol, or by increased cyclic AMP production, demonstrating that both signaling systems can increase the expression of a RGS family member in a single cell type. Carbachol 145-154 paired like homeodomain 2 Homo sapiens 34-37