PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26355753-4 2015 Addition of the full agonist carbamoylcholine activated and opened the nAChR ion channel, as revealed by the increase in capacitance relative to that of the nAChR-thiolipid system under basal conditions. Carbachol 29-45 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 71-76 26355753-4 2015 Addition of the full agonist carbamoylcholine activated and opened the nAChR ion channel, as revealed by the increase in capacitance relative to that of the nAChR-thiolipid system under basal conditions. Carbachol 29-45 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 157-162 21940627-5 2011 Carbachol, a known nAChR and muscarinic receptor agonist, up-regulated both alpha4beta2 nAChR binding sites and subunit protein 2-fold more than did nicotine. Carbachol 0-9 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 19-24 22902499-5 2012 KEY FINDINGS: Both nAChR and mAChR antagonists (hexamethonium and methacine, respectively), per se, elevated histamine-releasing activity of the HMC-1 and suppressed the MC responses to most of investigated activators (carbachol, compound 48/80, and to a lesser extent aIgG). Carbachol 219-228 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 19-24 21940627-5 2011 Carbachol, a known nAChR and muscarinic receptor agonist, up-regulated both alpha4beta2 nAChR binding sites and subunit protein 2-fold more than did nicotine. Carbachol 0-9 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 88-93 9132013-1 1997 The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded using the attenuated total reflectance technique in the presence and absence of carbamylcholine exhibits a complex pattern of positive and negative bands that provides a spectral map of the structural changes that occur in the nAChR upon agonist binding and subsequent desensitization. Carbachol 177-192 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 81-86 11846996-3 2001 AChR function measured by carbachol-induced (22)Na+ influx demonstrated that dimethoate may inhibit the nAChR function either by binding to a noncompetitive site and changing the conformational state of nAChR or by blocking the nAChR channel directly. Carbachol 26-35 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 104-109 9132013-1 1997 The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded using the attenuated total reflectance technique in the presence and absence of carbamylcholine exhibits a complex pattern of positive and negative bands that provides a spectral map of the structural changes that occur in the nAChR upon agonist binding and subsequent desensitization. Carbachol 177-192 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 47-79 18989912-3 2008 The high nAChR activity of carbamoylcholine analogue 5d was found to reside in its R-enantiomer, a characteristic most likely true for all other compounds in the series. Carbachol 27-43 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 9-14 16354194-7 2005 In the presence of the agonist carbachol, the effects of SLURP-1 on gene expression were augmented, which is in keeping with the notion that SLURP-1 acts as an allosteric agonist at the KC nAChR. Carbachol 31-40 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 189-194 12490593-2 2003 Magnitudes of acute, nAChR-mediated, specific 86Rb+ efflux responses to 1 mM carbamylcholine were reduced after pretreatment with specific nAChR ligands in effects that depended on pretreatment drug dose, duration of drug pretreatment, and duration of drug-free recovery. Carbachol 77-92 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 21-26 12490593-2 2003 Magnitudes of acute, nAChR-mediated, specific 86Rb+ efflux responses to 1 mM carbamylcholine were reduced after pretreatment with specific nAChR ligands in effects that depended on pretreatment drug dose, duration of drug pretreatment, and duration of drug-free recovery. Carbachol 77-92 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 139-144 11305656-3 2001 The nicotinic acetylcholine receptor (nAChr) agonists acetylcholine, carbachol, and (-)-nicotine were fractionated and detected by patch-clamped pheochromcytoma detector cells. Carbachol 69-78 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 38-43 10049140-1 1998 The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change. Carbachol 140-155 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 47-79 10049140-1 1998 The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change. Carbachol 140-155 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 81-86 10049140-1 1998 The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change. Carbachol 157-161 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 47-79 10049140-1 1998 The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change. Carbachol 157-161 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 81-86 10049140-1 1998 The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change. Carbachol 252-256 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 47-79 10049140-1 1998 The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change. Carbachol 252-256 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 81-86 10049140-4 1998 Spectral variations are also observed that are indicative of both the displacement of the anesthetics from the nAChR upon the addition of Carb and physical interactions that occur between the anesthetics and binding site residues. Carbachol 138-142 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 111-116 9132013-1 1997 The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded using the attenuated total reflectance technique in the presence and absence of carbamylcholine exhibits a complex pattern of positive and negative bands that provides a spectral map of the structural changes that occur in the nAChR upon agonist binding and subsequent desensitization. Carbachol 177-192 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 324-329 8923487-3 1996 Acute exposure to SP inhibits carbamylcholine- or nicotine-stimulated function measured using 86Rb+ efflux assays of human ganglionic (alpha 3 beta 4) nAChR expressed in SH-SY5Y neuroblastoma cells (IC50 approximately 2.3 microM) or of human muscle-type (alpha 1 beta 1 gamma delta) nAChR expressed in TE671/RD clonal cells (IC50 approximately 21 microM). Carbachol 30-45 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 151-156 2514612-8 1989 Specific FITC-alpha-BGT binding to the nAChR protein on the optic fibers was inhibited by agonists (e.g., acetylcholine, nicotine, and carbamylcholine) and antagonists (e.g., pancuronium and d-tubocurarine) of the nAChR and was insensitive to high salt concentrations (e.g., 154 mM NaCl). Carbachol 135-150 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 39-44 8788942-15 1995 The rate of myoblast fusion was increased by carbachol, an effect antagonized by alpha-bungarotoxin, curare and decamethonium, but not by atropine, indicating that nAChR were involved. Carbachol 45-54 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 164-169 7516704-1 1994 The secondary structure and effects of two ligands, carbamylcholine and tetracaine, on the secondary structure of affinity-purified nicotinic acetylcholine receptor (nAChR) from Torpedo has been studied using Fourier transform infrared spectroscopy (FTIR). Carbachol 52-67 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 132-164 7516704-1 1994 The secondary structure and effects of two ligands, carbamylcholine and tetracaine, on the secondary structure of affinity-purified nicotinic acetylcholine receptor (nAChR) from Torpedo has been studied using Fourier transform infrared spectroscopy (FTIR). Carbachol 52-67 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 166-171 1505686-2 1992 The binding and interaction of carbamoylcholine with the nicotinic acetylcholine receptor was investigated using photolytically released carbamoylcholine ("caged" carbamoylcholine). Carbachol 31-47 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 57-89 1505686-2 1992 The binding and interaction of carbamoylcholine with the nicotinic acetylcholine receptor was investigated using photolytically released carbamoylcholine ("caged" carbamoylcholine). Carbachol 137-153 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 57-89 1505686-2 1992 The binding and interaction of carbamoylcholine with the nicotinic acetylcholine receptor was investigated using photolytically released carbamoylcholine ("caged" carbamoylcholine). Carbachol 137-153 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 57-89 1581507-7 1992 Fourier transform infrared difference spectra calculated from spectra recorded in the presence and absence of carbamylcholine show small, reproducible bands which reflect changes in nAChR structure upon desensitization. Carbachol 110-125 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 182-187 2002334-2 1991 Chronic (3-72-h) agonist (nicotine or carbamylcholine) treatment of cells led to a complete (TE671) or nearly complete (PC12) loss of functional nAChR responses, which is referred to as "functional inactivation." Carbachol 38-53 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 145-150 2002334-8 1991 Recovery of TE671 cell nAChR function following treatment with carbamylcholine, nicotine, or d-TC occurred with half-times of 1-3 days whether cells were maintained in situ or harvested and replated after removal of ligand. Carbachol 63-78 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 23-28 2475163-12 1989 The spectroscopic properties of the fluorescent probe ethidium have been used to investigate the effect of the mAbs on the interaction of the agonist carbamylcholine with nAChR in membranes. Carbachol 150-165 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 171-176