PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3420006-2 1988 Results of these studies indicate that norepinephrine and carbachol evoke pharmacologically and temporally distinctive patterns of antral gastrin release. Carbachol 58-67 gastrin Rattus norvegicus 138-145 3420006-3 1988 Dose-response experiments indicate that norepinephrine is approximately 10,000 times more potent on a molar basis than carbachol in stimulating antral gastrin release. Carbachol 119-128 gastrin Rattus norvegicus 151-158 6114896-0 1981 Somatostatin inhibition of basal and carbachol-stimulated gastrin release in rat antral organ culture. Carbachol 37-46 gastrin Rattus norvegicus 58-65 3596169-8 1987 These results suggest that gastrin G is cosecreted with gastrin in response to carbachol and bombesin, and the stimulation of gastrin and gastrin-G secretion by bombesin does not involve cholinergic neural pathways and may reflect a direct action on gastrin cells. Carbachol 79-88 gastrin Rattus norvegicus 27-34 3596169-8 1987 These results suggest that gastrin G is cosecreted with gastrin in response to carbachol and bombesin, and the stimulation of gastrin and gastrin-G secretion by bombesin does not involve cholinergic neural pathways and may reflect a direct action on gastrin cells. Carbachol 79-88 gastrin Rattus norvegicus 56-63 3596169-8 1987 These results suggest that gastrin G is cosecreted with gastrin in response to carbachol and bombesin, and the stimulation of gastrin and gastrin-G secretion by bombesin does not involve cholinergic neural pathways and may reflect a direct action on gastrin cells. Carbachol 79-88 gastrin Rattus norvegicus 56-63 3596169-8 1987 These results suggest that gastrin G is cosecreted with gastrin in response to carbachol and bombesin, and the stimulation of gastrin and gastrin-G secretion by bombesin does not involve cholinergic neural pathways and may reflect a direct action on gastrin cells. Carbachol 79-88 gastrin Rattus norvegicus 56-63 3596169-8 1987 These results suggest that gastrin G is cosecreted with gastrin in response to carbachol and bombesin, and the stimulation of gastrin and gastrin-G secretion by bombesin does not involve cholinergic neural pathways and may reflect a direct action on gastrin cells. Carbachol 79-88 gastrin Rattus norvegicus 56-63 2884697-4 1987 Inclusion of carbachol (2.5 X 10(-6) M) in culture medium increased medium gastrin concentration by 106 +/- 28% (P less than 0.01); addition of specific antibodies to gastrin-releasing peptide to the culture medium did not affect carbachol-stimulated gastrin release. Carbachol 13-22 gastrin Rattus norvegicus 75-82 3569746-2 1986 Gastrin secretion was significantly stimulated by exogenous bombesin at a dose of 10(-8) M. Atropine 10(-6) M, which abolished the action of the cholinergic agent carbachol to stimulate gastrin secretion, had no effect on bombesin-stimulated gastrin secretion. Carbachol 163-172 gastrin Rattus norvegicus 0-7 3569746-2 1986 Gastrin secretion was significantly stimulated by exogenous bombesin at a dose of 10(-8) M. Atropine 10(-6) M, which abolished the action of the cholinergic agent carbachol to stimulate gastrin secretion, had no effect on bombesin-stimulated gastrin secretion. Carbachol 163-172 gastrin Rattus norvegicus 186-193 3569746-2 1986 Gastrin secretion was significantly stimulated by exogenous bombesin at a dose of 10(-8) M. Atropine 10(-6) M, which abolished the action of the cholinergic agent carbachol to stimulate gastrin secretion, had no effect on bombesin-stimulated gastrin secretion. Carbachol 163-172 gastrin Rattus norvegicus 242-249 2877911-1 1986 Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release. Carbachol 70-79 gastrin Rattus norvegicus 0-7 2877911-1 1986 Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release. Carbachol 70-79 gastrin Rattus norvegicus 169-176 2877911-1 1986 Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release. Carbachol 70-79 gastrin Rattus norvegicus 331-338 2877911-1 1986 Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release. Carbachol 70-79 gastrin Rattus norvegicus 388-395 2877911-1 1986 Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release. Carbachol 306-315 gastrin Rattus norvegicus 0-7 2877911-1 1986 Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release. Carbachol 306-315 gastrin Rattus norvegicus 169-176 2869695-3 1986 Inclusion of carbachol (2.5 X 10(-6) M) in the culture medium increased media gastrin concentrations from 3.29 +/- 0.76 (SE) (control) to 6.77 +/- 0.76 ng/mg tissue prot (P less than 0.02). Carbachol 13-22 gastrin Rattus norvegicus 78-85 2869695-4 1986 Rat antral mucosa was then incubated in the presence of GIP (10(-10) to 10(-7) M) to determine its effect on carbachol-stimulated gastrin release. Carbachol 109-118 gastrin Rattus norvegicus 130-137 2869695-5 1986 GIP significantly inhibited carbachol-stimulated gastrin release into the culture media at all concentrations examined. Carbachol 28-37 gastrin Rattus norvegicus 49-56 2869695-6 1986 To determine whether inhibition of carbachol-stimulated gastrin release by GIP was mediated by somatostatin, antral mucosa was incubated in the presence of carbachol, GIP (10(-10) to 10(-7) M), and specific antibodies to somatostatin in excess. Carbachol 35-44 gastrin Rattus norvegicus 56-63 2869695-7 1986 Inclusion of antibodies to somatostatin in the culture medium abolished the capacity of GIP (10(9) to 10(-7) M) to inhibit carbachol-stimulated gastrin release. Carbachol 123-132 gastrin Rattus norvegicus 144-151 2857528-3 1985 Carbachol at a dose of 10(-6) M inhibited SLI and stimulated gastrin secretion. Carbachol 0-9 gastrin Rattus norvegicus 61-68 2857528-5 1985 Pirenzepine caused a progressive parallel rightward shift in the dose-response curves for SLI inhibition and gastrin stimulation by carbachol, suggesting competitive inhibition. Carbachol 132-141 gastrin Rattus norvegicus 109-116 6436084-2 1984 In the presence of either divalent cationic chelator (EGTA) or calcium channel blocker (verapamil, nifedipine), carbachol-stimulated gastrin release was inhibited completely to values that were not significantly different from non-stimulated control. Carbachol 112-121 gastrin Rattus norvegicus 133-140 6436084-3 1984 In the absence of added calcium chloride, carbachol stimulated gastrin release during the initial 30 min of culture but not at 69 and 120 min of culture. Carbachol 42-51 gastrin Rattus norvegicus 63-70 6436084-4 1984 Inhibition by EGTA and verapamil of carbachol-stimulated gastrin release during the initial 30 min of culture suggests, but does not prove, that these agents may also effect intracellular availability and movement of calcium. Carbachol 36-45 gastrin Rattus norvegicus 57-64 6144613-2 1984 The purpose of this study was to examine further the relationships between gastrin and somatostatin and the effects of the cholinergic agonist carbachol on content and release of gastrin and somatostatin using rat antral mucosa in tissue culture. Carbachol 143-152 gastrin Rattus norvegicus 179-186 6144613-6 1984 Carbachol also increased culture media gastrin from 14 +/- 2.5 to 27 +/- 3.0 ng/mg protein (p less than 0.01). Carbachol 0-9 gastrin Rattus norvegicus 39-46 6138366-9 1983 To determine whether secretion inhibition of carbachol-stimulated gastrin release was mediated by somatostatin, antral mucosa was cultured with carbachol, secretin (10(-9)-10(-7) M), and antibodies to somatostatin. Carbachol 45-54 gastrin Rattus norvegicus 66-73 6138366-10 1983 Inclusion of somatostatin antibodies in the culture medium abolished the capacity of secretin (10(-7) and 10(-8) M) to inhibit carbachol-stimulated gastrin release. Carbachol 127-136 gastrin Rattus norvegicus 148-155 6138366-11 1983 Results of these studies indicate (a) that secretin inhibits carbachol-stimulated gastrin release and (b) that under the conditions of these experiments secretin inhibition of gastrin release is mediated, at least in part, locally through release of antral somatostatin. Carbachol 61-70 gastrin Rattus norvegicus 82-89 2869695-8 1986 Results of these studies indicate 1) that GIP inhibits carbachol-stimulated gastrin release and 2) that, under the conditions of these experiments, GIP inhibition of gastrin release may be mediated locally through release of antral somatostatin. Carbachol 55-64 gastrin Rattus norvegicus 76-83 2876015-1 1986 Rat antral mucosae maintained for 6 h in organ culture responded to carbamylcholine with a significant increase in endogenous cyclic GMP production and gastrin secretion. Carbachol 68-83 gastrin Rattus norvegicus 152-159 2876015-2 1986 The acetylcholine analogue exerted a stimulatory action within a defined concentration range: exposure of antral explants to carbachol concentrations greater than the optimal stimulatory dose was accompanied by a marked decrease in both cyclic GMP production and gastrin release. Carbachol 125-134 gastrin Rattus norvegicus 263-270 6138366-2 1983 The present studies were directed to examine the effect of secretin on carbachol-stimulated gastrin release and to assess the potential role of somatostatin in mediating this effect. Carbachol 71-80 gastrin Rattus norvegicus 92-99 6138366-5 1983 Carbachol (2.5 X 10(-6) M) in the culture medium increased gastrin level in the medium from 14.1 +/- 2.5 to 26.9 +/- 3.0 ng/mg tissue protein (P less than 0.02), and decreased somatostatin-like immunoreactivity in the medium from 1.91 +/- 0.28 to 0.62 +/- 0.12 ng/mg (P less than 0.01) and extracted mucosal somatostatin-like immunoreactivity from 2.60 +/- 0.30 to 1.52 +/- 0.16 ng/mg (P less than 0.001). Carbachol 0-9 gastrin Rattus norvegicus 59-66 6138366-6 1983 Rat antral mucosa was then cultured in the presence of secretin to determine its effect on carbachol-stimulated gastrin release. Carbachol 91-100 gastrin Rattus norvegicus 112-119 6138366-7 1983 Inclusion of secretin (10(-9)-10(-7) M) inhibited significantly carbachol-stimulated gastrin release into the medium, decreasing gastrin from 26.9 +/- 3.0 to 13.6 +/- 3.2 ng/mg (10(-9) M secretin) (P less than 0.05), to 11.9 +/- 1.7 ng/mg (10(-8) secretin) (P less than 0.02), and to 10.8 +/- 4.0 ng/mg (10(-7) M secretin) (P less than 0.02). Carbachol 64-73 gastrin Rattus norvegicus 85-92 6138366-7 1983 Inclusion of secretin (10(-9)-10(-7) M) inhibited significantly carbachol-stimulated gastrin release into the medium, decreasing gastrin from 26.9 +/- 3.0 to 13.6 +/- 3.2 ng/mg (10(-9) M secretin) (P less than 0.05), to 11.9 +/- 1.7 ng/mg (10(-8) secretin) (P less than 0.02), and to 10.8 +/- 4.0 ng/mg (10(-7) M secretin) (P less than 0.02). Carbachol 64-73 gastrin Rattus norvegicus 129-136 6114896-4 1981 Gastrin release into the culture media stimulated by the cholinergic agent, carbachol (10(-5) M), was suppressed by somatostatin: at 30 min and 6 h of culture 10(-8) M somatostatin inhibited carbachol-stimulated gastrin release by 66% and 54%, respectively, and 10(-5) M and 10(-4) M somatostatin completely abolished gastrin release. Carbachol 76-85 gastrin Rattus norvegicus 0-7 6114896-4 1981 Gastrin release into the culture media stimulated by the cholinergic agent, carbachol (10(-5) M), was suppressed by somatostatin: at 30 min and 6 h of culture 10(-8) M somatostatin inhibited carbachol-stimulated gastrin release by 66% and 54%, respectively, and 10(-5) M and 10(-4) M somatostatin completely abolished gastrin release. Carbachol 76-85 gastrin Rattus norvegicus 212-219 6114896-4 1981 Gastrin release into the culture media stimulated by the cholinergic agent, carbachol (10(-5) M), was suppressed by somatostatin: at 30 min and 6 h of culture 10(-8) M somatostatin inhibited carbachol-stimulated gastrin release by 66% and 54%, respectively, and 10(-5) M and 10(-4) M somatostatin completely abolished gastrin release. Carbachol 76-85 gastrin Rattus norvegicus 318-325 6114896-4 1981 Gastrin release into the culture media stimulated by the cholinergic agent, carbachol (10(-5) M), was suppressed by somatostatin: at 30 min and 6 h of culture 10(-8) M somatostatin inhibited carbachol-stimulated gastrin release by 66% and 54%, respectively, and 10(-5) M and 10(-4) M somatostatin completely abolished gastrin release. Carbachol 191-200 gastrin Rattus norvegicus 0-7 6114896-5 1981 The rate of gastrin release stimulated by carbachol was suppressed significantly by each dose of somatostatin examined (10(-8) M to 10(-4) M). Carbachol 42-51 gastrin Rattus norvegicus 12-19 6117361-6 1981 intravenous infusion of carbachol (1 microgram.kg-1.min-1) strongly stimulated luminal somatostatin and gastrin release (from 5 +/- 1 to 192 +/- 52 pg.mL-1 and from 27 +/- 5 to 198 +/- 41 pg.mL-1, respectively) during perfusion with 0.1 M HCl. Carbachol 24-33 gastrin Rattus norvegicus 104-111 6109792-5 1981 Because high carbachol concentrations were needed to produce gastrin secretion, and inhibition by atropine occurred also at high concentrations, these effects may be nonspecific. Carbachol 13-22 gastrin Rattus norvegicus 61-68 6109792-6 1981 Both carbachol- and norepinephrine-mediated gastrin release are modified by somatostatin and adenosine. Carbachol 5-14 gastrin Rattus norvegicus 44-51 33795544-6 2021 In carbachol-contracted gastric and ileal strips, contractile changes were recorded by adding NES- 1 (0.3 nmol/L), GLP-1, CCK-1, and gastrin/CCK-2 antagonists. Carbachol 3-12 gastrin Rattus norvegicus 133-140 7380199-1 1980 The purpose of the present study was to examine the effects of the cholinergic agent carbachol on gastrin synthesis and secretion by rat antral mucosa in organ culture. Carbachol 85-94 gastrin Rattus norvegicus 98-105 7380199-2 1980 In addition, the effect of atropine on basal and carbachol-stimulated gastrin release was investigated. Carbachol 49-58 gastrin Rattus norvegicus 70-77 7380199-3 1980 These in vitro studies demonstrate that carbachol stimulated both gastrin secretion and synthesis in a dose-dependent manner. Carbachol 40-49 gastrin Rattus norvegicus 66-73 7380199-4 1980 Maximal stimulation of gastrin synthesis and release occurred at a concentration of 1 X 10(-5) M carbachol. Carbachol 97-106 gastrin Rattus norvegicus 23-30 7380199-5 1980 The rate of gastrin release stimulated by carbachol (1 X10(-5) M) was 0.79 ng-hr-1-mg-1 which was significantly greater than the control value of 0.37 ng-hr-1 (P less than 0.001). Carbachol 42-51 gastrin Rattus norvegicus 12-19 7380199-7 1980 However, carbachol-stimulated gastrin release was inhibited progressively by inclusion of increasing concentrations of atropine in the culture media. Carbachol 9-18 gastrin Rattus norvegicus 30-37 7380199-8 1980 The results of these studies indicated that the acetylcholine analogue, carbachol, is capable of directly stimulating the antral gastrin cell to significantly increase the rate of synthesis and release of gastrin. Carbachol 72-81 gastrin Rattus norvegicus 129-136 7380199-8 1980 The results of these studies indicated that the acetylcholine analogue, carbachol, is capable of directly stimulating the antral gastrin cell to significantly increase the rate of synthesis and release of gastrin. Carbachol 72-81 gastrin Rattus norvegicus 205-212 7380199-9 1980 Whereas atropine, under these in vitro conditions, does not alter basal gastrin release, the muscarinic antagonist does competively inhibit carbachol-stimulated gastrin secretion. Carbachol 140-149 gastrin Rattus norvegicus 161-168 1692187-2 1990 In this fraction, basal gastrin release (mean +/- SE) was 31.1 +/- 1.3 pg.10(6) cells-1.60 min-1 and was stimulated by 10(-8) M neuromedin C (222.3 +/- 18.1% of basal), 10(-4) M carbachol (227.5 +/- 25.9%), 10(-6) M 12-O-tetradecanoylphorbol-13-acetate (TPA) (196.3 +/- 14.7%), and 10(-3) M dibutyryl adenosine 3",5"-cyclic monophosphate (DBcAMP) (193.9 +/- 6.8%), respectively. Carbachol 178-187 gastrin Rattus norvegicus 24-31 9468094-12 1998 In this preparation carbachol (10(-4) M) and neuromedin C (10(-9) M) significantly stimulated gastrin release from 2.6 +/- 0.4 to 4.9 +/- 0.3 and 8.5 +/- 0.9% of the total cellular content, respectively, while GABA (10(-10)-10(-3) M) changed neither basal nor carbachol- and neuromedin C-stimulated gastrin release. Carbachol 20-29 gastrin Rattus norvegicus 94-101 9468094-12 1998 In this preparation carbachol (10(-4) M) and neuromedin C (10(-9) M) significantly stimulated gastrin release from 2.6 +/- 0.4 to 4.9 +/- 0.3 and 8.5 +/- 0.9% of the total cellular content, respectively, while GABA (10(-10)-10(-3) M) changed neither basal nor carbachol- and neuromedin C-stimulated gastrin release. Carbachol 20-29 gastrin Rattus norvegicus 299-306 9468094-12 1998 In this preparation carbachol (10(-4) M) and neuromedin C (10(-9) M) significantly stimulated gastrin release from 2.6 +/- 0.4 to 4.9 +/- 0.3 and 8.5 +/- 0.9% of the total cellular content, respectively, while GABA (10(-10)-10(-3) M) changed neither basal nor carbachol- and neuromedin C-stimulated gastrin release. Carbachol 260-269 gastrin Rattus norvegicus 94-101 9073150-0 1997 Effect of carbachol on vascular and luminal release of immunoreactive gastrin from isolated perfused rat duodenum. Carbachol 10-19 gastrin Rattus norvegicus 70-77 8801525-0 1996 Change in subcellular localization of gastrin-like immunoreactivity in epithelial cells of rat duodenum induced by carbachol. Carbachol 115-124 gastrin Rattus norvegicus 38-45 8801525-6 1996 However, in carbachol-stimulated animals, immunogold labeling as well as DAB reactions were accumulated at the apical portion of the cytoplasm, suggesting that a high concentration of gastrin was involved in the apical cytoplasm. Carbachol 12-21 gastrin Rattus norvegicus 184-191 8801525-9 1996 These findings suggest that the gastrin-like immunoreactivity was pooled at the matrix of apical cytoplasm in carbachol-stimulated cells, which might be derived from the secretory granules migrated from the basal cytoplasm into apical portion of the cells. Carbachol 110-119 gastrin Rattus norvegicus 32-39 8801525-10 1996 In conclusion, the present study demonstrated the change in subcellular localization of gastrin-like immunoreactivity in intestinal gastrin cells after stimulation with carbachol. Carbachol 169-178 gastrin Rattus norvegicus 88-95 2226784-2 1990 Carbachol induced an increase in intracellular Ca2+ and stimulated gastrin release in a dose-dependent manner over the range 10(-5)-10(-3) M. These effects were completely abolished by atropine, suggesting the implication of muscarinic cholinergic receptors. Carbachol 0-9 gastrin Rattus norvegicus 67-74 2226784-7 1990 These results suggest the M3 muscarinic receptors may be involved in the carbachol-induced gastrin release from B6 RIN cells. Carbachol 73-82 gastrin Rattus norvegicus 91-98 9100288-6 1997 Gastrin treatment (5 micrograms.kg-1.h-1) of CR rats restored the gastric acid responses to both histamine and carbachol. Carbachol 111-120 gastrin Rattus norvegicus 0-7 9100288-7 1997 These results suggest that CR can selectively decrease the gastric acid responses to both histamine and carbachol by depletion of the endogenous tissue stores of gastrin. Carbachol 104-113 gastrin Rattus norvegicus 162-169 8964409-7 1996 Gastrin cells respond to both gastrin-releasing peptide and carbachol but not to cholecystokinin-receptor agonists. Carbachol 60-69 gastrin Rattus norvegicus 0-7 8630331-3 1996 The increase of cytosolic free Ca2+ promoted by gastrin, or carbachol, was abolished by the intracellular Ca2+ chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid (BAPTA, 10 microM). Carbachol 60-69 gastrin Rattus norvegicus 48-55 8801525-10 1996 In conclusion, the present study demonstrated the change in subcellular localization of gastrin-like immunoreactivity in intestinal gastrin cells after stimulation with carbachol. Carbachol 169-178 gastrin Rattus norvegicus 132-139 8093872-1 1993 We have examined the release of gastrin and somatostatin from the isolated perfused stomach of rats of three different age groups (4 months, 12 months, and 24 months old) in response to bombesin and carbachol. Carbachol 199-208 gastrin Rattus norvegicus 32-39 8093872-4 1993 Bombesin (10(-10) and 10(-9) M) and carbachol (10(-8) and 10(-7) M) stimulated gastrin release in each age group. Carbachol 36-45 gastrin Rattus norvegicus 79-86 8093872-5 1993 The integrated release of gastrin in response to bombesin (10(-10) and 10(-9) M) or carbachol (10(-8) M) did not differ among the three age groups, although integrated gastrin release in response to carbachol (10(-7) M) decreased in 24-month-old rats. Carbachol 84-93 gastrin Rattus norvegicus 26-33 8093872-5 1993 The integrated release of gastrin in response to bombesin (10(-10) and 10(-9) M) or carbachol (10(-8) M) did not differ among the three age groups, although integrated gastrin release in response to carbachol (10(-7) M) decreased in 24-month-old rats. Carbachol 199-208 gastrin Rattus norvegicus 168-175 8093872-8 1993 Compared with 4-month-old rats, the inhibition of somatostatin release by carbachol was less in 24-month-old rats at 10(-8) and 10(-7) M, and less in 12-month-old rats at 10(-7) M. The decreased basal gastrin secretion and well-preserved gastrin response were further confirmed in conscious aged rats tested by means of oral gavage with 10% peptone. Carbachol 74-83 gastrin Rattus norvegicus 201-208 8093872-8 1993 Compared with 4-month-old rats, the inhibition of somatostatin release by carbachol was less in 24-month-old rats at 10(-8) and 10(-7) M, and less in 12-month-old rats at 10(-7) M. The decreased basal gastrin secretion and well-preserved gastrin response were further confirmed in conscious aged rats tested by means of oral gavage with 10% peptone. Carbachol 74-83 gastrin Rattus norvegicus 238-245