PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12429914-0	2002	The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression).	4-Butyrolactone	38-51	cyclin dependent kinase inhibitor 1A	Homo sapiens	77-80	
12429914-0	2002	The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression).	4-Butyrolactone	38-51	cyclin dependent kinase inhibitor 1A	Homo sapiens	82-86	
12429914-0	2002	The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression).	4-Butyrolactone	38-51	cyclin dependent kinase inhibitor 1A	Homo sapiens	87-91	
11329882-3	2000	In this study, we found that butyrolactone I, a specific inhibitor of CDC2 family kinases, blocks the X-ray- or doxorubicin-induced apoptosis of DLD1 (p21+/+) human colorectal carcinoma cells in a dose-dependent manner.	4-Butyrolactone	29-42	cyclin dependent kinase inhibitor 1A	Homo sapiens	151-154	
11329882-4	2000	We also found that butyrolactone I inhibits the CDK2 activity and enhances cell survival after an X-ray irradiation or doxorubicin treatment in both DLD1 (p21-/-) and DLD1 (p21+/+) cells.	4-Butyrolactone	19-32	cyclin dependent kinase inhibitor 1A	Homo sapiens	155-158	
11329882-4	2000	We also found that butyrolactone I inhibits the CDK2 activity and enhances cell survival after an X-ray irradiation or doxorubicin treatment in both DLD1 (p21-/-) and DLD1 (p21+/+) cells.	4-Butyrolactone	19-32	cyclin dependent kinase inhibitor 1A	Homo sapiens	173-176	
11329882-5	2000	These findings suggest that butyrolactone I prevents apoptosis by the direct inhibition of CDK and also, possibly, by CDK-inhibition through p53-independent p21-induction.	4-Butyrolactone	28-41	cyclin dependent kinase inhibitor 1A	Homo sapiens	157-160	
9488034-4	1998	When cells were treated with mimosine, a p53-independent p21-inducer, or butyrolactone I, a specific inhibitor of CDK, cellular endogenous p21 was induced and X-ray or adriamycin-induced apoptosis was blocked.	4-Butyrolactone	73-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	139-142