PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34054556-8 2021 Expression of indoleamine 2,3-dioxygenase 2 (IDO2) and kynurenine 3-monooxygenase (KMO) was increased by poly (I:C) whereas kynurenine aminotransferase II and its metabolite kynurenic acid were not altered. Kynurenine 55-65 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 83-86 35204197-1 2022 Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA). Kynurenine 54-64 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 0-26 35204197-1 2022 Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA). Kynurenine 54-64 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 28-31 33607168-2 2021 Kynurenine 3-monooxygenase (KMO) is a pivotal enzyme in the metabolism of KYN to 3-hydroxykynurenine. Kynurenine 74-77 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 0-26 33607168-2 2021 Kynurenine 3-monooxygenase (KMO) is a pivotal enzyme in the metabolism of KYN to 3-hydroxykynurenine. Kynurenine 74-77 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 28-31 30760699-3 2019 We show that KMO is highly expressed in the kidney and exerts major metabolic control over the biologically active kynurenine metabolites 3-hydroxykynurenine, kynurenic acid, and downstream metabolites. Kynurenine 115-125 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 13-16 32268268-2 2020 Kynurenine 3-monooxygenase (KMO), a crucial kynurenine metabolic enzyme, is involved in inflammation, immune response and tumorigenesis. Kynurenine 44-54 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 0-26 32268268-2 2020 Kynurenine 3-monooxygenase (KMO), a crucial kynurenine metabolic enzyme, is involved in inflammation, immune response and tumorigenesis. Kynurenine 44-54 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 28-31 32151061-4 2020 We generated a knockout mouse strain of kynurenine 3-monooxygenase (KMO), an enzyme in the kynurenine pathway that produces neurotoxic 3-hydroxykynurenine. Kynurenine 40-50 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 68-71 33750843-1 2021 Kynurenine 3-monooxygenase (KMO) regulates the levels of neuroactive metabolites in the kynurenine pathway (KP), dysregulation of which is associated with Huntington"s disease (HD) pathogenesis. Kynurenine 88-98 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 0-26 33750843-1 2021 Kynurenine 3-monooxygenase (KMO) regulates the levels of neuroactive metabolites in the kynurenine pathway (KP), dysregulation of which is associated with Huntington"s disease (HD) pathogenesis. Kynurenine 88-98 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 28-31 28709913-3 2017 We investigated whether brain interleukin (IL)-1 signaling and activity of kynurenine 3-monoxygenase (KMO), a key enzyme for metabolism of kynurenine into the neurotoxic NMDA receptor agonist quinolinic acid, are necessary for comorbid neuropathic pain and depression-like behavior. Kynurenine 75-85 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 102-105 29879409-1 2018 Kynurenine 3-monooxygenase (KMO) is an essential enzyme of the kynurenine pathway, converting kynurenine into 3-hydroxykynurenine. Kynurenine 63-73 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 0-26 29879409-1 2018 Kynurenine 3-monooxygenase (KMO) is an essential enzyme of the kynurenine pathway, converting kynurenine into 3-hydroxykynurenine. Kynurenine 63-73 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 28-31 29879409-1 2018 Kynurenine 3-monooxygenase (KMO) is an essential enzyme of the kynurenine pathway, converting kynurenine into 3-hydroxykynurenine. Kynurenine 94-104 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 0-26 29879409-1 2018 Kynurenine 3-monooxygenase (KMO) is an essential enzyme of the kynurenine pathway, converting kynurenine into 3-hydroxykynurenine. Kynurenine 94-104 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 28-31 29879409-2 2018 Inhibition of KMO increases kynurenine, resulting in elevated levels of kynurenic acid (KYNA), an endogenous N-methyl-d-aspartate and alpha*7-nicotinic receptor antagonist. Kynurenine 28-38 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 14-17 30354938-6 2018 RESULTS:: Maternal kynurenine treatment raised kynurenic acid levels significantly more in the brain of heterozygous offspring of Kmo+/- than in the brain of Kmo+/+ offspring. Kynurenine 19-29 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 130-133 30354938-6 2018 RESULTS:: Maternal kynurenine treatment raised kynurenic acid levels significantly more in the brain of heterozygous offspring of Kmo+/- than in the brain of Kmo+/+ offspring. Kynurenine 19-29 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 158-161 30354938-7 2018 Conversely, 3-hydroxykynurenine and quinolinic acid levels in the fetal brain tended to be lower in heterozygous animals derived from kynurenine-treated Kmo+/- mice than in corresponding Kmo+/+ offspring. Kynurenine 21-31 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 153-156 30354938-9 2018 Kynurenine treatment also caused a preferential elevation in cerebral kynurenic acid levels in Kmo+/- compared to Kmo+/+ dams. Kynurenine 0-10 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 95-98 30354938-9 2018 Kynurenine treatment also caused a preferential elevation in cerebral kynurenic acid levels in Kmo+/- compared to Kmo+/+ dams. Kynurenine 0-10 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 114-117 28187857-1 2017 BACKGROUND: Kynurenine 3-monooxygenase converts kynurenine to 3-hydroxykynurenine, and its inhibition shunts the kynurenine pathway-which is implicated as dysfunctional in various psychiatric disorders-toward enhanced synthesis of kynurenic acid, an antagonist of both alpha7 nicotinic acetylcholine and N-methyl-D-aspartate receptors. Kynurenine 48-58 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 12-38 28187857-1 2017 BACKGROUND: Kynurenine 3-monooxygenase converts kynurenine to 3-hydroxykynurenine, and its inhibition shunts the kynurenine pathway-which is implicated as dysfunctional in various psychiatric disorders-toward enhanced synthesis of kynurenic acid, an antagonist of both alpha7 nicotinic acetylcholine and N-methyl-D-aspartate receptors. Kynurenine 71-81 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 12-38 28507519-6 2017 LPS-induced hypotension in mice was prevented by pre-treatment with the kynurenine monooxygenase (KMO) inhibitor, Ro-618048, which lowered serum levels of XA but enhanced serum levels of L-kynurenine. Kynurenine 187-199 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 98-101 27693848-3 2017 Kynurenine 3-monooxygenase (KMO), a pivotal enzyme in the KP, has been suggested to play major roles in physiological and pathological events mediated by bioactive kynurenine metabolites. Kynurenine 164-174 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 28-31 27693848-3 2017 Kynurenine 3-monooxygenase (KMO), a pivotal enzyme in the KP, has been suggested to play major roles in physiological and pathological events mediated by bioactive kynurenine metabolites. Kynurenine 164-174 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 0-26 27693848-11 2017 These findings suggested that KMO KO mice show antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions via abnormality of kynurenine metabolism with good validities as MDD model. Kynurenine 150-160 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 30-33 27889626-4 2017 Kynurenine 3-monooxygenase (KMO) is one of the key regulatory enzymes, which metabolizes kynurenine to 3-hydroxykynurenine in the KP. Kynurenine 89-99 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 0-26 27889626-4 2017 Kynurenine 3-monooxygenase (KMO) is one of the key regulatory enzymes, which metabolizes kynurenine to 3-hydroxykynurenine in the KP. Kynurenine 89-99 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 28-31 27623092-1 2016 To quantify the full range of tryptophan metabolites along the kynurenine pathway, a liquid chromatography - tandem mass spectrometry method was developed and used to analyse brain extracts of rodents treated with the kynurenine-3-mono-oxygenase (KMO) inhibitor Ro61-8048 during pregnancy. Kynurenine 63-73 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 218-245 27623092-0 2016 Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2+/- mice, using liquid chromatography-tandem mass spectrometry. Kynurenine 0-10 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 49-52 27623092-5 2016 The results confirm the marked increase in the accumulation of some neuroactive kynurenines when KMO is inhibited, and re-emphasise the potential importance of changes in anthranilic acid. Kynurenine 80-91 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 97-100 27754481-11 2016 Whereas kynurenine metabolism was generally increased in behaviorally salient brain regions, a distinct shift toward KMO-dependent kynurenine metabolism occurred in the dorsal hippocampus in response to LPS. Kynurenine 131-141 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 117-120 24189070-1 2013 Kynurenine 3-monooxygenase (KMO), a pivotal enzyme in the kynurenine pathway (KP) of tryptophan degradation, has been suggested to play a major role in physiological and pathological events involving bioactive KP metabolites. Kynurenine 58-68 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 0-26 24189070-1 2013 Kynurenine 3-monooxygenase (KMO), a pivotal enzyme in the kynurenine pathway (KP) of tryptophan degradation, has been suggested to play a major role in physiological and pathological events involving bioactive KP metabolites. Kynurenine 58-68 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 28-31 24189070-6 2013 The levels of three other KP metabolites: kynurenine, kynurenic acid, and anthranilic acid, were substantially, but differentially, elevated in the liver, brain, and plasma of Kmo(-/-) mice, whereas the liver and brain content of the major end product of the enzymatic cascade, NAD(+), did not differ between Kmo(-/-) and wild-type animals. Kynurenine 42-52 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 176-179 23511700-3 2013 Using mass-spectrometry (LC-MS) analysis of kynurenine metabolites in the brain of mice injected at the periphery with 1 mg/kg LPS, we show that LPS activates the kynurenine 3-monooxygenase pathway that ultimately degrades kynurenine into quinolinic acid. Kynurenine 44-54 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 163-189 23575632-2 2013 KMO is a flavin adenine dinucleotide (FAD)-dependent monooxygenase and is located in the outer mitochondrial membrane where it converts l-kynurenine to 3-hydroxykynurenine. Kynurenine 136-148 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 0-3 23124849-7 2012 In addition, the lack of the accumulation of kynurenine and its downstream metabolites in the pre-arthritic lymph nodes coincided with increased mRNA expression for genes involved in the catabolism of kynurenine (Kynureninase, kynurenine 3-monooxygenase, and 3-hydroxyanthranilate 3,4 dioxygenase). Kynurenine 201-211 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 227-282