PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32744329-7 2020 Moreover, cytochrome P45017A1 (CYP17A1) mRNA levels in the theca layer were affected and correlated with follicular androstendione and estradiol concentration. Androstenedione 116-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 10-29 32681807-1 2020 Human cytochrome P450 CYP17A1 first catalyzes hydroxylation at the C17 position of either PREG or PROG, and a subsequent C 17 -C 20 bond scission to produce dehydroepiandrosterone ( DHEA) or androstenedione (AD). Androstenedione 191-206 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 32681807-1 2020 Human cytochrome P450 CYP17A1 first catalyzes hydroxylation at the C17 position of either PREG or PROG, and a subsequent C 17 -C 20 bond scission to produce dehydroepiandrosterone ( DHEA) or androstenedione (AD). Androstenedione 208-210 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 32744329-7 2020 Moreover, cytochrome P45017A1 (CYP17A1) mRNA levels in the theca layer were affected and correlated with follicular androstendione and estradiol concentration. Androstenedione 116-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 31-38 24832628-1 2015 Androstenedione is a common precursor of sex steroids produced and secreted in the human adrenal gland and produced by 3beta-hydroxysteroid dehydrogenase (3betaHSD), 17beta-hydroxylase/17,20-lyase (CYP17) and cytochrome b5 (CYB5A). Androstenedione 0-15 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 198-203 29283561-5 2018 Replacement of asparagine 202 with serine completely reverses the preference of CYP17A1, more than doubling the rate of turnover of the OHPROG to androstenedione reaction and substantially decreasing the rate of formation of dehydroepiandrosterone from OHPREG. Androstenedione 146-161 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 80-87 31933595-1 2019 Background: CYP17A1 is involved in the steroidogenesis of dehydroepiandrosterone and androstenedione. Androstenedione 85-100 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 12-19 28684414-1 2017 Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17alpha,20-lyase reactions to form dehydroepiandrosterone (DHEA) and androstenedione (Andro), respectively, critical for generating glucocorticoids and androgens. Androstenedione 241-256 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-32 28684414-1 2017 Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17alpha,20-lyase reactions to form dehydroepiandrosterone (DHEA) and androstenedione (Andro), respectively, critical for generating glucocorticoids and androgens. Androstenedione 258-263 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-32 26526982-6 2016 In conclusion, factors such as c-fos may play a crucial role in the down-regulation of CYP17 and up-regulation of CYP19 in granulosa cells, thereby suppressing androstenedione synthesis. Androstenedione 160-175 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 87-92 23470964-3 2013 CYP17A1 catalyzes two essential reactions in the production of DHEA and androstenedione: the hydroxylation (hydroxylase activity) and the subsequent cleavage of the C17-20 side chain (lyase activity). Androstenedione 72-87 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 24314739-3 2013 RESULTS: Inhibition of CYP17A1 with abiraterone acetate induces changes in steroid metabolism, whose main component is the reduction of DHEA and androstenedione synthesis. Androstenedione 145-160 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 23-30 22155568-0 2012 Luteinizing hormone (LH) regulates production of androstenedione and progesterone via control of histone acetylation of StAR and CYP17 promoters in ovarian theca cells. Androstenedione 49-64 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 129-134 15477877-3 2004 The linear trends across the CYP17 genotypes in serum-free testosterone and androstenedione levels were found, suggesting the importance of the polymorphism of CYP17 in determining the circulating androgen levels. Androstenedione 76-91 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 29-34 21918127-8 2012 In experiment 2 (cells coexpressing P450c17, 3betaHSD, and CPR), androstenedione secretion was (paradoxically) higher at lower levels of 3betaHSD, and partial inhibition of 3betaHSD by trilostane also increased androstenedione when 3betaHSD expression was high. Androstenedione 65-80 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 36-43 21918127-8 2012 In experiment 2 (cells coexpressing P450c17, 3betaHSD, and CPR), androstenedione secretion was (paradoxically) higher at lower levels of 3betaHSD, and partial inhibition of 3betaHSD by trilostane also increased androstenedione when 3betaHSD expression was high. Androstenedione 211-226 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 36-43 21868758-3 2011 DHEA and androstenedione are synthesized by the adrenals through the sequential actions of the cytochrome P450 enzymes CYP11A1 and CYP17A1, so that CYP17A1 inhibitors such as abiraterone are effective therapies for CRPC. Androstenedione 9-24 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 131-138 21868758-3 2011 DHEA and androstenedione are synthesized by the adrenals through the sequential actions of the cytochrome P450 enzymes CYP11A1 and CYP17A1, so that CYP17A1 inhibitors such as abiraterone are effective therapies for CRPC. Androstenedione 9-24 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 148-155 17326004-3 2007 Sebocytes express very little of the key enzyme, cytochrome P450c17, necessary for synthesis of the androgenic prohormones dehydroepiandrosterone and androstenedione, however, these prohormones can be converted by sebocytes and sweat glands, and probably also by dermal papilla cells, into more potent androgens like testosterone and dihydrotestosterone. Androstenedione 150-165 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 49-67 22024430-6 2012 In these species, P450c17 has negligible 17,20-lyase activity with the Delta(4)-steroid 17alpha-hydroxy-progesterone (17OH-P4); therefore androstenedione (A4) is synthesized efficiently only from dehydroepiandrosterone (DHEA) through the Delta(5) pathway. Androstenedione 138-153 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 18-25 21307141-8 2011 Measurement of 17alpha-hydroxyprogesterone, androstenedione, and their aromatized products in the media further demonstrated CYP17 expression and activity in the human trophoblast. Androstenedione 44-59 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 125-130 19850690-13 2009 CONCLUSIONS: These results suggest that the AP-1 transcription factor, c-fos, may be one of the factors responsible for CYP17 repression and hence suppression of androstenedione production in granulosa cells. Androstenedione 162-177 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 120-125 16828825-5 2006 CYP17 enzyme catalyzes an important step in sex steroidogenesis and is responsible for the biosynthesis of dehydroepiandrosterone (DHEA) and androstenedione in the adrenals. Androstenedione 141-156 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 14504283-1 2003 Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase reactions. Androstenedione 148-163 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 14504283-1 2003 Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase reactions. Androstenedione 148-163 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 20-25 14504283-6 2003 In contrast, mutation E305G exhibits 11-fold greater catalytic efficiency (kcat/Km) for the cleavage of 17alpha-hydroxyprogesterone to androstenedione compared with wild-type CYP17. Androstenedione 135-150 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 175-180 15477877-3 2004 The linear trends across the CYP17 genotypes in serum-free testosterone and androstenedione levels were found, suggesting the importance of the polymorphism of CYP17 in determining the circulating androgen levels. Androstenedione 76-91 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 160-165 12788891-6 2003 The presence of 3 beta-HSD type 2 and P450c17 indicated that conversion of pregnenolone to dehydroepiandrosterone (DHEA) and to androstenedione may take place effectively in kidney. Androstenedione 128-143 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 38-45 14522586-8 2003 The brisk metabolism of 5alpha-pregnan-3alpha,17alpha-diol-20-one to androsterone by CYP17 explains how, when 5alpha-reductases are present, the testis can produce C(19) steroids androsterone and androstanediol from 17alpha-hydroxyprogesterone without the intermediacy of androstenedione and testosterone. Androstenedione 272-287 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 85-90 12915666-2 2003 P450c17 can mediate testosterone biosynthesis via the conversion of pregnenolone to dehydroepiandrosterone (the delta(5) pathway) or via conversion of progesterone to androstenedione (the delta(4) pathway). Androstenedione 167-182 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 12573489-2 2003 In particular, the human P450c17 selectively produces dehydroepiandrosterone with little androstenedione (AD). Androstenedione 89-104 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 25-32 12573489-2 2003 In particular, the human P450c17 selectively produces dehydroepiandrosterone with little androstenedione (AD). Androstenedione 106-108 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 25-32 11751282-12 2002 We conclude that putative ligand-mediated activation of PPARgamma decreases LH- and/or insulin-driven theca cell androgen production by impairing the ability of CYP17 to synthesize androstenedione from available progestins. Androstenedione 181-196 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 161-166 9888582-2 1998 Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human P450c17 catalyzes this reaction very inefficiently, so that virtually all human C19 sex steroids are made via 17OH pregnenolone and DHEA. Androstenedione 118-140 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 19-26 10999829-21 2000 In conclusion, BMP-4 inhibits HOTT cell expression of CYP17, leading to an alteration of steroidogenic pathway resulting in reduced androstenedione accumulation and increased progesterone production. Androstenedione 132-147 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 54-59 9888582-2 1998 Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human P450c17 catalyzes this reaction very inefficiently, so that virtually all human C19 sex steroids are made via 17OH pregnenolone and DHEA. Androstenedione 118-140 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 152-159 9467556-12 1998 In conclusion, the present study demonstrated a potent inhibitory effect of CRF on LH-stimulated dehydroepiandrosterone and androstenedione production that appears to be mediated through the reduction of P450c17 gene expression. Androstenedione 124-139 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 204-211 8623837-11 1996 Transforming growth factor-beta 1 inhibited forskolin stimulation of androstenedione production through the inhibition of P450c17 expression. Androstenedione 69-84 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 122-129 9257124-5 1997 The human choriogonadotropin-induced degradation of cytochrome P450c17 in incubated decapsulated testes can not be correlated with a stimulation of lipid peroxidation, and it is partially inhibited by estradiol but completely abolished by androstenedione. Androstenedione 239-254 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 63-70 34662099-7 2021 For example, the replacement of the glutamic acid side with a glycine chain at position 305 in the CYP17A1 structure causes a clinically relevant steroidopathy; E305G CYP17A1 displays a dramatic decrease in the production of dehydroepiandrosterone from pregnenolone but surprisingly increases the activity of the enzyme toward the formation of androstenedione from progesterone. Androstenedione 344-359 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 99-106 8948449-14 1995 17 alpha-Hydroxyprogesterone was a poor substrate for the human CYP17; although it was converted into androstenedione in the presence of cytochrome b5 its K(m) was 5 times higher and Vmax. Androstenedione 102-117 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-69 34662099-7 2021 For example, the replacement of the glutamic acid side with a glycine chain at position 305 in the CYP17A1 structure causes a clinically relevant steroidopathy; E305G CYP17A1 displays a dramatic decrease in the production of dehydroepiandrosterone from pregnenolone but surprisingly increases the activity of the enzyme toward the formation of androstenedione from progesterone. Androstenedione 344-359 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 167-174 33656879-1 2021 CYP17A1 is an essential human steroidogenic enzyme, which catalyzes two sequential reactions leading to the formation of androstenedione from progesterone and dehydroepiandrosterone from pregnenolone. Androstenedione 121-136 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7