PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9029727-1	1997	Studies of the regulation of androgen synthesis in steroidogenic cells have focused on both transcriptional and post-translational regulation of the proteins that catalyze these reactions: the P450c17 that catalyzes the production of DHEA or androstenedione in consecutive hydroxylase and lyase activities, and the 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) that catalyzes the conversion of androstenedione to testosterone.	Androstenedione	242-257	aldo-keto reductase family 1, member C12	Rattus norvegicus	315-351	
12830367-1	2003	Exposure of pubertal rats to di-(2-ethylhexyl) phthalate (DEHP) for 14 days was reported to result in reduced testosterone (T) biosynthesis by altering androstenedione 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity.	Androstenedione	152-167	aldo-keto reductase family 1, member C12	Rattus norvegicus	168-203	
9475159-5	1998	The present results demonstrate that only 17beta-hydroxysteroid dehydrogenase seems to be involved in the AA action, since nearly 60% inhibition of testosterone production was found when the cells were incubated with androstenedione.	Androstenedione	217-232	aldo-keto reductase family 1, member C12	Rattus norvegicus	42-77	
3199812-0	1988	Aromatase-inhibitors of the androstenedione-type activate the 17 beta-hydroxysteroid-dehydrogenase in the rat testis tissue suspension model.	Androstenedione	28-43	aldo-keto reductase family 1, member C12	Rattus norvegicus	62-98	
2158194-2	1990	5 alpha-reductase and 17 beta-hydroxysteroid dehydrogenase activities, which are involved in the conversion of testosterone to dihydrotestosterone and androstenedione, respectively, were low in cultured neonatal interstitial cells, were unresponsive to hCG and declined to undetectable levels during 14 days of culture.	Androstenedione	151-166	aldo-keto reductase family 1, member C12	Rattus norvegicus	22-58	
3199812-4	1988	The consequent consideration of the whole labelled steroidal spectrum in each experiment leads to the conclusion that androstenedione and the derived aromatase inhibitors activate the 17 beta-hydroxysteroid-dehydrogenase in a product activating manner.	Androstenedione	118-133	aldo-keto reductase family 1, member C12	Rattus norvegicus	184-220	
2850159-7	1988	When 14C-labeled androstenedione was incubated with microsomal fraction of testicular or ovarian tissue, glycyrrhizin and glycyrrhetinic acid inhibited the conversion of androstenedione to testosterone, indicating that these compounds inhibit the activity of 17 beta-hydroxysteroid dehydrogenase (EC.	Androstenedione	170-185	aldo-keto reductase family 1, member C12	Rattus norvegicus	259-295	
2850159-7	1988	When 14C-labeled androstenedione was incubated with microsomal fraction of testicular or ovarian tissue, glycyrrhizin and glycyrrhetinic acid inhibited the conversion of androstenedione to testosterone, indicating that these compounds inhibit the activity of 17 beta-hydroxysteroid dehydrogenase (EC.	Androstenedione	17-32	aldo-keto reductase family 1, member C12	Rattus norvegicus	259-295	
6243214-2	1980	To investigate this phenomenon, the activity of 17 beta-hydroxysteroid dehydrogenase, the enzyme directly related to testosterone production from androstenedione, was measured.	Androstenedione	146-161	aldo-keto reductase family 1, member C12	Rattus norvegicus	48-84	
3161163-6	1985	17 beta-hydroxysteroid dehydrogenase favored androstenedione formation, and hence oestrone formation, in the ovaries and testosterone formation, and hence oestradiol formation, in the testes.	Androstenedione	45-60	aldo-keto reductase family 1, member C12	Rattus norvegicus	0-36