PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8594318-13 1996 The results raise the possibility that the adrenal androgen, androstenedione can regulate the expression of TXA2 receptors either on its own or via conversion to testosterone and through an androgen receptor. Androstenedione 61-76 androgen receptor Homo sapiens 190-207 18645714-6 2008 Furthermore, we correlated the AR (CAG)(n) with serum testosterone, androstenedione, dehydroepiandrosterone sulfate and several parameters of glucose and lipid metabolism in each group and in all 121 women. Androstenedione 68-83 androgen receptor Homo sapiens 31-33 15924334-7 2005 In addition, this series of compounds displayed potent inhibition of 17beta-HSD3-mediated cellular conversion of AdT to testosterone and inhibited the 17beta-HSD3-mediated conversion of testosterone necessary to promote AR-dependent transcription. Androstenedione 113-116 androgen receptor Homo sapiens 220-222 15522925-0 2005 Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. Androstenedione 0-29 androgen receptor Homo sapiens 36-53 10987273-5 2000 beta-Catenin also increased AR transcriptional activation by androstenedione and estradiol and diminished the antagonism of bicalutamide. Androstenedione 61-76 androgen receptor Homo sapiens 28-30 16759873-2 2006 Our previous collaborative study demonstrated that androst-5-ene-3beta,17beta-diol (Adiol) and androst-4-ene-3,17-dione (Adione), metabolites of DHEA, can activate androgen receptor (AR) target genes. Androstenedione 95-119 androgen receptor Homo sapiens 164-181 16759873-2 2006 Our previous collaborative study demonstrated that androst-5-ene-3beta,17beta-diol (Adiol) and androst-4-ene-3,17-dione (Adione), metabolites of DHEA, can activate androgen receptor (AR) target genes. Androstenedione 95-119 androgen receptor Homo sapiens 183-185 16759873-2 2006 Our previous collaborative study demonstrated that androst-5-ene-3beta,17beta-diol (Adiol) and androst-4-ene-3,17-dione (Adione), metabolites of DHEA, can activate androgen receptor (AR) target genes. Androstenedione 121-127 androgen receptor Homo sapiens 164-181 16759873-2 2006 Our previous collaborative study demonstrated that androst-5-ene-3beta,17beta-diol (Adiol) and androst-4-ene-3,17-dione (Adione), metabolites of DHEA, can activate androgen receptor (AR) target genes. Androstenedione 121-127 androgen receptor Homo sapiens 183-185 15522925-2 2005 To determine whether 4-androstenedione has androgenic/anabolic properties, we evaluated its association with androgen receptor (AR) and its effects on myogenesis in vitro. Androstenedione 21-38 androgen receptor Homo sapiens 109-126 15522925-2 2005 To determine whether 4-androstenedione has androgenic/anabolic properties, we evaluated its association with androgen receptor (AR) and its effects on myogenesis in vitro. Androstenedione 21-38 androgen receptor Homo sapiens 128-130 15522925-9 2005 Stimulatory effects of 4-androstenedione on myosin heavy chain II+ myotubes and myogenic determination factor expression were attenuated by bicalutamide, an AR antagonist. Androstenedione 23-40 androgen receptor Homo sapiens 157-159 15522925-12 2005 4-androstenedione is an androgen that binds AR, induces AR nuclear translocation, and promotes myogenesis in vitro, with substantially lower potency than dihydrotestosterone. Androstenedione 0-17 androgen receptor Homo sapiens 44-46 15522925-12 2005 4-androstenedione is an androgen that binds AR, induces AR nuclear translocation, and promotes myogenesis in vitro, with substantially lower potency than dihydrotestosterone. Androstenedione 0-17 androgen receptor Homo sapiens 56-58 21868758-2 2011 One important mechanism mediating this AR reactivation is intratumoral conversion of the weak adrenal androgens DHEA and androstenedione into the AR ligands testosterone and dihydrotestosterone. Androstenedione 121-136 androgen receptor Homo sapiens 39-41 34520388-7 2021 Pattern I, characterized by androstenedione and testosterone hydroxylated metabolites (11beta-OHT; 2beta-OHT; 15beta-OHT; 2alpha-OHT; 6beta-OHT), was associated with high prostate cancer odds among carriers of androgen receptor gene (CAG)>19 repeats (OR: 3.67 95% CI: 1.23-11.0; p for interaction=0.009). Androstenedione 28-43 androgen receptor Homo sapiens 210-227 31845837-5 2020 RESULTS: In LAPC4 and VCaP cells testosterone, dihydrotestosterone and androstenedione induced androgen receptor transcriptional activity, while dehydroepiandrosterone, 5alpha-androstan-3beta,17beta-diol, androstenediol and androsterone stimulated androgen receptor only in VCaP cells. Androstenedione 71-86 androgen receptor Homo sapiens 95-112 31845837-5 2020 RESULTS: In LAPC4 and VCaP cells testosterone, dihydrotestosterone and androstenedione induced androgen receptor transcriptional activity, while dehydroepiandrosterone, 5alpha-androstan-3beta,17beta-diol, androstenediol and androsterone stimulated androgen receptor only in VCaP cells. Androstenedione 71-86 androgen receptor Homo sapiens 248-265 31845837-7 2020 The total androgen receptor transcriptional activity secondary to testosterone, dihydrotestosterone and androstenedione was associated with time to castration resistance in patients from the PR.7 study (HR 2.17, 95% CI 1.12-4.23, p=0.02) in multivariate analysis using the castration sensitive model (LAPC4). Androstenedione 104-119 androgen receptor Homo sapiens 10-27 31845837-8 2020 Androgen receptor transcriptional activity of extragonadal androstenedione was the only steroid statistically associated with time to castration resistance in univariate analysis (HR 1.89, 95% CI 1.04-3.44, p=0.036). Androstenedione 59-74 androgen receptor Homo sapiens 0-17 27345701-2 2017 Androstenedione (A4), 11beta-hydroxyandrostenedione (11OHA4) and 11beta-hydroxytestosterone (11OHT) are metabolised to potent androgen receptor (AR) agonists, dihydrotestosterone (DHT), 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT). Androstenedione 0-15 androgen receptor Homo sapiens 126-143 21868758-2 2011 One important mechanism mediating this AR reactivation is intratumoral conversion of the weak adrenal androgens DHEA and androstenedione into the AR ligands testosterone and dihydrotestosterone. Androstenedione 121-136 androgen receptor Homo sapiens 146-148 20534728-5 2010 We hypothesized that activation of AR in prostate cancer by DHEA and A5diol requires their conversion via 3betaHSD to androstenedione and testosterone, respectively. Androstenedione 118-133 androgen receptor Homo sapiens 35-37