PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23285696-9 2012 IP6 at all used concentrations had no influence on transcription of p65 gene and modulated expression of p50 and IkappaBalpha genes in Caco-2 cells. Phytic Acid 0-3 NFKB inhibitor alpha Homo sapiens 113-125 23285696-11 2012 The results of these studies suggest that IP6 may exert immunoregulatory effects on intestinal epithelium by influencing transcriptional activity of genes encoding p50 subunit of NF-kappaB, its inhibitor IkappaBalpha and proinflammatory cytokines IL-6 and IL-8. Phytic Acid 42-45 NFKB inhibitor alpha Homo sapiens 204-216 14666688-8 2003 IP6-treated cells also showed a strong inhibition in phospho-I kappa B alpha protein levels concomitant with a significant increase in total I kappa B alpha levels. Phytic Acid 0-3 NFKB inhibitor alpha Homo sapiens 61-76 19172851-2 2008 The aim of this study was to evaluate the influence of phytic acid on the expression of genes encoding p65 and p50 subunits of NF-kappaB and of its inhibitor IkappaBalpha in human colorectal cancer cell line Caco-2. Phytic Acid 55-66 NFKB inhibitor alpha Homo sapiens 158-170 19172851-4 2008 Treatment of cells with 5 mM IP6 resulted in a strong increase in IkappaBalpha expression at 6 h, 12 h and 24 h. The level of p65 transcript after 1 h was lower in the cells exposed to 1, 2.5, and 5 mM IP6 than in the control cells. Phytic Acid 29-32 NFKB inhibitor alpha Homo sapiens 66-78 19172851-4 2008 Treatment of cells with 5 mM IP6 resulted in a strong increase in IkappaBalpha expression at 6 h, 12 h and 24 h. The level of p65 transcript after 1 h was lower in the cells exposed to 1, 2.5, and 5 mM IP6 than in the control cells. Phytic Acid 202-205 NFKB inhibitor alpha Homo sapiens 66-78 19172851-9 2008 The results of this study suggest that IP6 primarily influences p65 and IkappaBalpha genes expression in colon cancer cells. Phytic Acid 39-42 NFKB inhibitor alpha Homo sapiens 72-84 19172851-10 2008 Changes in transcriptional activities of IkappaBalpha and p65 depend on IP6 concentration and time of its action. Phytic Acid 72-75 NFKB inhibitor alpha Homo sapiens 41-53 14666688-8 2003 IP6-treated cells also showed a strong inhibition in phospho-I kappa B alpha protein levels concomitant with a significant increase in total I kappa B alpha levels. Phytic Acid 0-3 NFKB inhibitor alpha Homo sapiens 141-156