PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18950011-4 2008 Antisense oligonucleotide which directed blocked up the translation site resulted in growth inhibition, downregulation of Stat3, p-Stat3, Cyclins and CDKs, and upregulation of p21 and p27. Oligonucleotides 10-25 H3 histone pseudogene 16 Homo sapiens 176-179 15536518-2 2005 Therefore we are interested to improve the proliferation of primary myoblasts of DMD patients by a reduction in p21 using either antisense oligonucleotides (ASO) or short interfering RNAs (siRNA). Oligonucleotides 139-155 H3 histone pseudogene 16 Homo sapiens 112-115 17914575-8 2007 To demonstrate the degree of loss of function, functional assays in yeast and bacteria with oligonucleotides for competitive electrophoretic mobility shift assays (EMSAs) were done proving that this mutation decreases TP53 ability to bind DNA of the TP53 response element from the human p21 gene. Oligonucleotides 92-108 H3 histone pseudogene 16 Homo sapiens 287-290 16093429-4 2005 Transient transfection of H460 lung cancer cells and human umbilical vascular endothelial cells (HUVEC) with antisense oligonucleotides (ASODN) against MDM2 resulted in a reduced level of MDM2 and increased levels of p21 and p53. Oligonucleotides 119-135 H3 histone pseudogene 16 Homo sapiens 217-220 18380477-4 2008 An aggregation of Fas-procaspase 8-procaspase 3 and p21-procaspase 3 proteins by coimmunoprecipitation, immunoblotting analysis, and MALDI-mass spectrometry indicated the involvement of Fas and p21 in 1-mediated cytotoxicity, and pretreatment of cells with antisense FasL oligonucleotides partially abolished apoptosis. Oligonucleotides 272-288 H3 histone pseudogene 16 Homo sapiens 52-55 15185342-8 2004 Pretreatment of HUVEC with a p21 specific antisense oligonucleotide reversed the TB-induced inhibition of [(3)H]thymidine incorporation. Oligonucleotides 52-67 H3 histone pseudogene 16 Homo sapiens 29-32 15041706-11 2004 In addition, p21 antisense oligonucleotides inhibited PPARgamma ligand-induced p21 protein expression and significantly blocked lung carcinoma cell growth inhibition induced by PPARgamma ligands. Oligonucleotides 27-43 H3 histone pseudogene 16 Homo sapiens 13-16 15130767-8 2004 Pretreatment of HDMVECs with a p21 antisense oligonucleotide, which blocked the expression of p21 protein, reversed the BJ-601-induced inhibition of [3H]thymidine incorporation into HDMVECs. Oligonucleotides 45-60 H3 histone pseudogene 16 Homo sapiens 31-34 15130767-8 2004 Pretreatment of HDMVECs with a p21 antisense oligonucleotide, which blocked the expression of p21 protein, reversed the BJ-601-induced inhibition of [3H]thymidine incorporation into HDMVECs. Oligonucleotides 45-60 H3 histone pseudogene 16 Homo sapiens 94-97 15041706-11 2004 In addition, p21 antisense oligonucleotides inhibited PPARgamma ligand-induced p21 protein expression and significantly blocked lung carcinoma cell growth inhibition induced by PPARgamma ligands. Oligonucleotides 27-43 H3 histone pseudogene 16 Homo sapiens 79-82 14667929-9 2004 Pretreatment of HUVEC with a p21 antisense oligonucleotide reversed the DPTH-induced inhibition of [3H]thymidine incorporation into HUVEC. Oligonucleotides 43-58 H3 histone pseudogene 16 Homo sapiens 29-32 12732930-3 2003 In this context we are interested to improve the proliferation of primary human skeletal muscle cells (SkMC) by a reduction in the cell cycle proteins p21 and p57 using the appropriate antisense oligonucleotides (ASO). Oligonucleotides 195-211 H3 histone pseudogene 16 Homo sapiens 151-154 14751837-6 2003 The antisense oligonucleotides also potentiated the effects of p53 activation and p21 induction by chemotherapeutic agents 10-hydroxycamptothecin, adriamycin, 5-fluorouracil, and paclitaxel. Oligonucleotides 14-30 H3 histone pseudogene 16 Homo sapiens 82-85 12920809-4 2003 Targeting of Stat3 using antisense oligonucleotide which directed against the translation site resulted in growth inhibition, downregulation of Stat3, p-Stat3, Cyclins and CDKs, and up-regulation of p21 and p27. Oligonucleotides 35-50 H3 histone pseudogene 16 Homo sapiens 199-202 12518324-7 2003 The antisense oligonucleotide also potentiated the effects of p53 activation and p21 induction by chemotherapeutic agents 10-hydroxycamptothecin, adriamycin, 5-fluorouracil, and paclitaxel. Oligonucleotides 14-29 H3 histone pseudogene 16 Homo sapiens 81-84 11029459-10 2001 Antisense oligonucleotides directed to Ki-Ras decreased both TbetaRIII post-translational modification in Ki-ras(G12V) cells and TGF-beta1 down-regulation of p21, demonstrating the direct effect of mutant Ras. Oligonucleotides 10-26 H3 histone pseudogene 16 Homo sapiens 158-161 3023062-1 1986 We synthesized a set of 20-mer oligonucleotides corresponding to a sequence of seven amino acids strictly conserved in all the different ras proteins, from yeast to man, as well as in rho and YPT, two proteins distantly related to p21 ras (approximately 30% amino acid homology). Oligonucleotides 31-47 H3 histone pseudogene 16 Homo sapiens 231-234 11894120-5 2002 In LS174T cells, the antisense oligonucleotide, but not the mismatch oligonucleotide, specifically inhibited MDM2 expression, resulting in a significant increase in irinotecan-associated p53 activation and p21 induction. Oligonucleotides 31-46 H3 histone pseudogene 16 Homo sapiens 206-209 11894120-6 2002 In DLD-1 cells, the antisense oligonucleotide specifically inhibited MDM2 expression, resulting in a significant increase in irinotecan-associated p21 induction although mutant p53 levels remained unchanged. Oligonucleotides 30-45 H3 histone pseudogene 16 Homo sapiens 147-150 11889192-4 2002 Addition of pifithrin-alpha, a specific inhibitor of p53, or transfection of p53 antisense oligonucleotides caused decreased RV-induced p53 and p21 expression in PTC and FTC cells. Oligonucleotides 91-107 H3 histone pseudogene 16 Homo sapiens 144-147 12017271-4 2002 Synergistic effects on p53 and p21 levels between the oligonucleotide and chemotherapeutic agents were also observed in vitro. Oligonucleotides 54-69 H3 histone pseudogene 16 Homo sapiens 31-34 9935156-8 1999 Mutation-matched anti-sense oligonucleotides effectively inhibited the growth of these pancreatic cancer cell lines, except for BxPC-3, by suppressing K-ras mRNA expression and K-ras p21 protein synthesis. Oligonucleotides 28-44 H3 histone pseudogene 16 Homo sapiens 183-186 9642224-5 1998 Increasing p21(ras) activity by expressing v-ras or by treatment with an antisense oligonucleotide to the GTPase-activating protein was found to accelerate the Fas-mediated apoptotic process in Jurkat and mouse LF cells. Oligonucleotides 83-98 H3 histone pseudogene 16 Homo sapiens 11-14 9419978-7 1997 Treatment with p21 antisense oligonucleotide partially blocked induction of p21 expression by paclitaxel and significantly reduced survival of MCF-7 cells exposed to this agent. Oligonucleotides 29-44 H3 histone pseudogene 16 Homo sapiens 15-18 9419978-7 1997 Treatment with p21 antisense oligonucleotide partially blocked induction of p21 expression by paclitaxel and significantly reduced survival of MCF-7 cells exposed to this agent. Oligonucleotides 29-44 H3 histone pseudogene 16 Homo sapiens 76-79