PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10807924-1 2000 An expression library for active site mutants of human topoisomerase IIalpha (TOP2alpha) was constructed by replacing the sequence encoding residues 793-808 with a randomized oligonucleotide cassette. Oligonucleotides 175-190 DNA topoisomerase II alpha Homo sapiens 78-87 9207016-1 1997 We have analysed the DNA cleavage reaction of DNA gyrase using oligonucleotides annealed to a single-stranded M13 derivative containing a preferred gyrase cleavage site. Oligonucleotides 63-79 DNA topoisomerase II alpha Homo sapiens 46-56 22841979-2 2012 To better understand how these enzymes act in both contexts, we determined the 2.9-A-resolution structure of the DNA cleavage core of human topoisomerase IIalpha (TOP2A) bound to a doubly nicked, 30-bp duplex oligonucleotide. Oligonucleotides 209-224 DNA topoisomerase II alpha Homo sapiens 163-168