PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29212210-5 2017 Accordingly, specific inhibition of miR-21 using antisense oligonucleotides markedly promoted B cell IL-10 expression. Oligonucleotides 59-75 interleukin 10 Homo sapiens 101-106 31164303-2 2019 The aim of this study was to evaluate the safety, efficacy, and to clarify the mechanism of a phosphorothioated interleukin (IL)-10-targeted antisense oligonucleotide (ASO) as an immune adjuvant in intradermal vaccination. Oligonucleotides 151-166 interleukin 10 Homo sapiens 112-131 31068803-12 2019 Cobitolimod is a single strand oligonucleotide, which mimics bacterial DNA as its CpG dinucleotide sequences can be recognized by the Toll-like receptor 9 on different immune cells thereby causing induction of different cytokines, for example IL10 and IFNalpha. Oligonucleotides 31-46 interleukin 10 Homo sapiens 243-247 16034145-8 2005 Finally, when fibroblasts were transiently transfected with IL-10 antisense oligonucleotides, the conditioned medium lost its T cell anti-apoptotic effect, whereas medium from fibroblasts transfected with IFN-beta antisense oligonucleotides displayed the same anti-apoptotic activity of medium from untransfected fibroblasts. Oligonucleotides 76-92 interleukin 10 Homo sapiens 60-65 17009241-8 2006 Preincubation of these cells with a 16-mer C-type decoy oligonucleotide fully reconstituted the defective IL-10-induced suppression of IL-12 synthesis. Oligonucleotides 56-71 interleukin 10 Homo sapiens 106-111 23814492-9 2013 Antisense oligonucleotides for SOCS1 and SOCS3 markedly reduced OK-432-induced IL-10 and TGF-beta. Oligonucleotides 10-26 interleukin 10 Homo sapiens 79-84 19766270-6 2010 Inhibiting PGC-1alpha expression by antisense oligonucleotide increases IL-10 expression and reduces the steatotic phenotype. Oligonucleotides 46-61 interleukin 10 Homo sapiens 72-77 19139565-7 2009 Stimulation of 1alpha25VitD3-induced IL-10-secreting Treg with TLR9 agonists, CpG oligonucleotides, resulted in decreased IL-10 and IFN-gamma synthesis and a concurrent loss of regulatory function, but, unexpectedly, increased IL-4 synthesis. Oligonucleotides 82-98 interleukin 10 Homo sapiens 37-42 19139565-7 2009 Stimulation of 1alpha25VitD3-induced IL-10-secreting Treg with TLR9 agonists, CpG oligonucleotides, resulted in decreased IL-10 and IFN-gamma synthesis and a concurrent loss of regulatory function, but, unexpectedly, increased IL-4 synthesis. Oligonucleotides 82-98 interleukin 10 Homo sapiens 122-127 16720211-3 2006 We analyzed the frequencies of three main variants of the promoter region of the IL-10 gene at the positions -1082, -819, and -592 in a cohort of 358 type 1 diabetic patients representing the same regional population pattern and 519 controls from the same region using an enzyme-linked oligonucleotide sorbent assay. Oligonucleotides 286-301 interleukin 10 Homo sapiens 81-86 16034145-8 2005 Finally, when fibroblasts were transiently transfected with IL-10 antisense oligonucleotides, the conditioned medium lost its T cell anti-apoptotic effect, whereas medium from fibroblasts transfected with IFN-beta antisense oligonucleotides displayed the same anti-apoptotic activity of medium from untransfected fibroblasts. Oligonucleotides 224-240 interleukin 10 Homo sapiens 60-65 14996748-10 2004 This sensitization can also be obtained by transfection of GBM cells with IL-10 antisense oligonucleotides. Oligonucleotides 90-106 interleukin 10 Homo sapiens 74-79 15001575-6 2004 The role of STAT3 in MC proliferation induced by IL-10 was deduced from results showing that IL-10-induced proliferation was abrogated if MC transfected with STAT3 antisense oligonucleotides were used or if cells were incubated with inhibitors of STAT3. Oligonucleotides 174-190 interleukin 10 Homo sapiens 49-54 15001575-6 2004 The role of STAT3 in MC proliferation induced by IL-10 was deduced from results showing that IL-10-induced proliferation was abrogated if MC transfected with STAT3 antisense oligonucleotides were used or if cells were incubated with inhibitors of STAT3. Oligonucleotides 174-190 interleukin 10 Homo sapiens 93-98 12857749-5 2003 Gel mobility shift analyses and decoy oligonucleotide experiments suggest that this effect of IL-10 is mediated through activation of the transcription factor STAT-3 (signal transducer and activator of transcription-3). Oligonucleotides 38-53 interleukin 10 Homo sapiens 94-99 10953968-6 2000 The pathogenetic role of IL-10 in AIDS-BL is suggested by the observation that IL-10 antisense oligonucleotides inhibit proliferation of the lymphoma. Oligonucleotides 95-111 interleukin 10 Homo sapiens 25-30 12538792-7 2003 The role of IL-10 was further documented by increased spontaneous proliferation of peripheral blood mononuclear cells of CF patients after preincubation with antisense oligonucleotides blocking the synthesis of IL-10 receptor-associated kinases janus tyrosine kinase 1 and tyrosine kinase 2. Oligonucleotides 168-184 interleukin 10 Homo sapiens 12-17 11118209-5 2000 On the other hand, growth of EBV-positive Akata cells was blocked by treatment either with an anti-IL-10 antibody or antisense oligonucleotide against IL-10. Oligonucleotides 127-142 interleukin 10 Homo sapiens 151-156 11163082-4 2000 Biallelic polymorphisms in the promoter region of the IL-10 gene associated with higher or lower production of IL-10 were determined in a SIDS and in a control group using a sequence-specific oligonucleotide approach. Oligonucleotides 192-207 interleukin 10 Homo sapiens 54-59 10953968-6 2000 The pathogenetic role of IL-10 in AIDS-BL is suggested by the observation that IL-10 antisense oligonucleotides inhibit proliferation of the lymphoma. Oligonucleotides 95-111 interleukin 10 Homo sapiens 79-84 10565029-0 2000 In vivo and in vitro antiproliferative effects of antisense interleukin 10 oligonucleotides. Oligonucleotides 75-91 interleukin 10 Homo sapiens 60-74 9341739-7 1997 Interestingly, inhibition of IL-10 protein synthesis with IL-10-specific antisense oligonucleotide DNA (IL-10-AS-ODN) induced HLA-D locus genes in these MHC class II-deficient patients. Oligonucleotides 83-98 interleukin 10 Homo sapiens 29-34 10468015-0 1999 Design of potent phosphorothioate antisense oligonucleotides directed to human interleukin 10 gene product and their evaluation of antisense activity in U937 cells. Oligonucleotides 44-60 interleukin 10 Homo sapiens 79-93 10468015-1 1999 PURPOSE: The two objectives of this study were to design potent phosphorothioate antisense oligonucleotides (AS-S-oligos) directed against the human interleukin-10 (IL-10) gene product and to reveal the DNA sequence which best activates antisense effects. Oligonucleotides 91-107 interleukin 10 Homo sapiens 149-163 10468015-1 1999 PURPOSE: The two objectives of this study were to design potent phosphorothioate antisense oligonucleotides (AS-S-oligos) directed against the human interleukin-10 (IL-10) gene product and to reveal the DNA sequence which best activates antisense effects. Oligonucleotides 91-107 interleukin 10 Homo sapiens 165-170 10210767-3 1999 Preliminary results have shown that antisense oligonucleotides (anti-ICAM), anti-cytokine antibodies (anti-TNF) or recombinant human cytokines (IL-10 or IL-11) are effective in some patients with Crohn"s disease refractory to steroids. Oligonucleotides 46-62 interleukin 10 Homo sapiens 144-149 9744754-4 1998 Oligonucleotide target probe sets were designed for several human cytokines, including TNFalpha, IL-2, IL-4, IL-6, IL-10, and IFNgamma. Oligonucleotides 0-15 interleukin 10 Homo sapiens 115-120 9516148-10 1998 Experiments using antisense oligonucleotides showed that the clonal growth of KS-1 and BC-1 was nearly 100% inhibited by IL-6 antisense oligonucleotides (10 micromol/L), but not at all by either oligonucleotides (</=10 micromol/L) to IL-6 sense, IL-6 scrambled, viral IL-6 (vIL-6) antisense, or IL-10 antisense. Oligonucleotides 136-152 interleukin 10 Homo sapiens 298-303 9516148-10 1998 Experiments using antisense oligonucleotides showed that the clonal growth of KS-1 and BC-1 was nearly 100% inhibited by IL-6 antisense oligonucleotides (10 micromol/L), but not at all by either oligonucleotides (</=10 micromol/L) to IL-6 sense, IL-6 scrambled, viral IL-6 (vIL-6) antisense, or IL-10 antisense. Oligonucleotides 136-152 interleukin 10 Homo sapiens 298-303 9341739-7 1997 Interestingly, inhibition of IL-10 protein synthesis with IL-10-specific antisense oligonucleotide DNA (IL-10-AS-ODN) induced HLA-D locus genes in these MHC class II-deficient patients. Oligonucleotides 83-98 interleukin 10 Homo sapiens 58-63 9341739-7 1997 Interestingly, inhibition of IL-10 protein synthesis with IL-10-specific antisense oligonucleotide DNA (IL-10-AS-ODN) induced HLA-D locus genes in these MHC class II-deficient patients. Oligonucleotides 83-98 interleukin 10 Homo sapiens 58-63 7780129-5 1995 An IL-10 antisense oligonucleotide inhibited IL-10 mRNA expression and IL-10 protein production. Oligonucleotides 19-34 interleukin 10 Homo sapiens 3-8 7780129-5 1995 An IL-10 antisense oligonucleotide inhibited IL-10 mRNA expression and IL-10 protein production. Oligonucleotides 19-34 interleukin 10 Homo sapiens 45-50 7780129-5 1995 An IL-10 antisense oligonucleotide inhibited IL-10 mRNA expression and IL-10 protein production. Oligonucleotides 19-34 interleukin 10 Homo sapiens 45-50 7780129-6 1995 The proliferation of all B-cell lines was inhibited by an antisense oligonucleotide in a dose-dependent manner that was abrogated by the addition of recombinant hIL-10 protein. Oligonucleotides 68-83 interleukin 10 Homo sapiens 161-167 9038663-6 1996 Expression of IL-4 and IL-10 messenger RNA was detected by in situ hybridisation with oligonucleotide probe cocktails for each cytokine. Oligonucleotides 86-101 interleukin 10 Homo sapiens 23-28 8186370-6 1993 Using digoxigenin-labelled oligonucleotide probes we have detected expression of the cytokines IL-1 alpha, IL-2, IL-4, IL-6, IL-10, IFN-gamma, TGF beta 1 & 2 and TNF-alpha in frozen sections of CNS tissue from MS cases. Oligonucleotides 27-42 interleukin 10 Homo sapiens 125-130