PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30530571-0 2019 Antisense oligonucleotides targeting angiotensinogen: insights from animal studies. Oligonucleotides 10-26 angiotensinogen Homo sapiens 37-52 30530571-2 2019 We review the recent preclinical research of AGT antisense oligonucleotides (ASOs), a rapidly evolving therapeutic approach. Oligonucleotides 59-75 angiotensinogen Homo sapiens 45-48 22850722-8 2012 OGT was the only AGT to show activity in the repair of oligonucleotides containing the mono-adducts O(4)-butyl-4-ol-2"-deoxythymidine and O(4)-heptyl-7-ol-2"-deoxythymidine. Oligonucleotides 55-71 angiotensinogen Homo sapiens 17-20 26888118-4 2016 In addition to whole-body genetic deletion, AGT can be regulated in vivo by cell-specific procedures, adeno-associated viral approaches and antisense oligonucleotides. Oligonucleotides 150-166 angiotensinogen Homo sapiens 44-47 29137116-7 2017 Finally, a method to generate a covalent conjugate between hAGT and a model nucleoside using a single-stranded oligonucleotide substrate is demonstrated. Oligonucleotides 111-126 angiotensinogen Homo sapiens 59-63 26459209-0 2015 Synthesis of oligonucleotides carrying fluorescently labelled O(6)-alkylguanine for measuring hAGT activity. Oligonucleotides 13-29 angiotensinogen Homo sapiens 94-98 19338750-5 2009 Furthermore, Ang II-induced MMP 2 activation was markedly blocked by SP600125, a selective c-Jun N-terminal kinase (JNK) inhibitor, or pre-treatment of cells with antisense oligonucleotide to focal adhesion kinase (FAK), indicating that both molecules were important for the activation of MMP 2 by Ang II receptor stimulation. Oligonucleotides 173-188 angiotensinogen Homo sapiens 13-19 20814019-6 2010 The Ang II-induced BDNF upregulation in RVLM was attenuated by coadministration of the NADPH oxidase inhibitor apocynin; the superoxide dismutase mimetic tempol; or an antisense oligonucleotide against CREB. Oligonucleotides 178-193 angiotensinogen Homo sapiens 4-10 20601126-7 2010 Transfection of VSMC with PTP-1B antisense oligonucleotide markedly reduced the effects of Ang II on insulin signaling. Oligonucleotides 43-58 angiotensinogen Homo sapiens 91-97 20858048-4 2010 To establish this chip, we designed and blotted onto a nylon membrane SNP-specific oligonucleotide probes for human angiotensinogen, cholesteryl ester transfer protein, and apolipoprotein E. Oligonucleotides 83-98 angiotensinogen Homo sapiens 116-131 19385060-7 2009 Moreover, the inhibitory effect of TGFbeta on AngII signaling occurs at the Mek-Erk interface and is abrogated when an anti-sense oligonucleotide directed against GRK2 is used. Oligonucleotides 130-145 angiotensinogen Homo sapiens 46-51 19211927-7 2009 Both oligonucleotide pulldown and chromatin immunoprecipitation assays revealed increased binding of JunD and HIF-1alpha to the AGT core promoter in response to TGF-beta1. Oligonucleotides 5-20 angiotensinogen Homo sapiens 128-131 19338750-5 2009 Furthermore, Ang II-induced MMP 2 activation was markedly blocked by SP600125, a selective c-Jun N-terminal kinase (JNK) inhibitor, or pre-treatment of cells with antisense oligonucleotide to focal adhesion kinase (FAK), indicating that both molecules were important for the activation of MMP 2 by Ang II receptor stimulation. Oligonucleotides 173-188 angiotensinogen Homo sapiens 298-304 17651610-9 2007 The alpha-SMA expression level (1.14 +/- 0.15) and Col I mRNA (0.30 +/- 0.04) of HLF cells transfected with antisense oligonucleotide incubated with Ang II decreased significantly as compared to those of sense and random oligonucleotide transfected cells. Oligonucleotides 221-236 angiotensinogen Homo sapiens 149-155 17651610-10 2007 Alpha-SMA expression level (0.85 +/- 0.09) and Col I mRNA (0.20 +/- 0.02) of Losartan + Ang II co-incubated antisense oligonucleotide transfected HLF cells decreased significantly as compared to Ang II treated alone. Oligonucleotides 118-133 angiotensinogen Homo sapiens 88-94 17651610-10 2007 Alpha-SMA expression level (0.85 +/- 0.09) and Col I mRNA (0.20 +/- 0.02) of Losartan + Ang II co-incubated antisense oligonucleotide transfected HLF cells decreased significantly as compared to Ang II treated alone. Oligonucleotides 118-133 angiotensinogen Homo sapiens 195-201 17504233-10 2007 Antisense oligonucleotides against TGF-beta1 mRNA or TGF-beta neutralizing antibodies, when applied to the fibrotic HIPF cells in serum-free medium, significantly reduced AGT expression. Oligonucleotides 10-26 angiotensinogen Homo sapiens 171-174 16750184-8 2006 Down-regulation of the p110beta isoform by antisense oligonucleotides inhibited the angiotensin II-induced signalling pathway but not the alpha-adrenoceptor-mediated hypertrophic growth of cardiomyocytes. Oligonucleotides 53-69 angiotensinogen Homo sapiens 84-98 16867255-0 2006 Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells. Oligonucleotides 55-70 angiotensinogen Homo sapiens 74-88 16867255-1 2006 AIM: The present study was designed to further investigate the effect of connective tissue growth factor antisense oligonucleotide (CTGF-AS) on angiotensin II (Ang II)-induced tubular cell epithelial mesenchymal transition (EMT) in vitro. Oligonucleotides 115-130 angiotensinogen Homo sapiens 144-158 16867255-1 2006 AIM: The present study was designed to further investigate the effect of connective tissue growth factor antisense oligonucleotide (CTGF-AS) on angiotensin II (Ang II)-induced tubular cell epithelial mesenchymal transition (EMT) in vitro. Oligonucleotides 115-130 angiotensinogen Homo sapiens 160-166 16834928-8 2006 STAT3 antisense oligonucleotides could inhibit both Ang II-induced STAT3-DNA binding activity as well as TIMP-1 expression. Oligonucleotides 16-32 angiotensinogen Homo sapiens 52-58 16150729-8 2005 AII-induced NAD(P)H oxidase activation was inhibited by 57-71% with antisense oligonucleotide against PDI (PDIasODN). Oligonucleotides 78-93 angiotensinogen Homo sapiens 0-3 16151022-4 2005 The Ang II-induced p38 MAPK or ERK1/2 phosphorylation was attenuated by application into the RVLM of a NADPH oxidase inhibitor, diphenyleneiodonium chloride (DPI), an antisense oligonucleotide that targets against p22phox or p47phox subunit of NADPH oxidase mRNA, or the superoxide dismutase mimetic tempol. Oligonucleotides 177-192 angiotensinogen Homo sapiens 4-10 16081100-3 2005 Five structures of AGT have been determined: a binary complex with the UDP product and four ternary complexes with UDP or UDP-glucose and oligonucleotides containing an A:G, HMU:G (hydroxymethyl uracyl) or AP:G (apurinic/apyrimidinic) mismatch at the target base-pair. Oligonucleotides 138-154 angiotensinogen Homo sapiens 19-22 12846741-14 2003 Northern and Western blots showed that STAT1 and STAT3 antisense oligonucleotides could inhibit angiotensin II-induced TIMP-1 expressions, and STAT1 and STAT3 proteins, respectively, could be supershifted by their polyclonal antibodies. Oligonucleotides 65-81 angiotensinogen Homo sapiens 96-110 15027896-8 2004 Antisense oligonucleotides for Nox4 NAD(P)H oxidase significantly reduce activation of ERK1/ERK2 by Ang II and AA. Oligonucleotides 10-26 angiotensinogen Homo sapiens 100-106 10677348-6 2000 In addition, the stimulatory effects of guanine nucleotides, isoproterenol, sodium fluoride and forskolin as well as the inhibitory effects of angiotensin II on adenylyl cyclase were not affected by antisense-oligonucleotide treatment. Oligonucleotides 209-224 angiotensinogen Homo sapiens 143-157 12676175-6 2003 Centrally administered AT(1) receptor antagonists or angiotensinogen antisense oligonucleotides inhibit sympathetic activity and reduce arterial blood pressure in certain physiological or pathophysiological conditions, as well as disrupting water drinking and sodium appetite, vasopressin secretion, sodium excretion, renin release and thermoregulation. Oligonucleotides 79-95 angiotensinogen Homo sapiens 53-68 12151404-7 2002 Incubation of AGT with DBE and oligodeoxyribonucleotides led to the formation of covalent AGT-oligonucleotide complexes. Oligonucleotides 94-109 angiotensinogen Homo sapiens 14-17 12151404-7 2002 Incubation of AGT with DBE and oligodeoxyribonucleotides led to the formation of covalent AGT-oligonucleotide complexes. Oligonucleotides 94-109 angiotensinogen Homo sapiens 90-93 12065324-13 2002 In cells transfected with gp91phox antisense oligonucleotides, Ang II-mediated actions were abrogated. Oligonucleotides 45-61 angiotensinogen Homo sapiens 63-69 11262415-0 2001 Down-regulation by antisense oligonucleotides establishes a role for the proline-rich tyrosine kinase PYK2 in angiotensin ii-induced signaling in vascular smooth muscle. Oligonucleotides 29-45 angiotensinogen Homo sapiens 110-124 11025447-7 2000 Transfection of primary cultures of rat AEC with antisense oligonucleotides against ANGEN mRNA inhibited the subsequent induction of TNF-stimulated apoptosis by 72% (P < 0.01). Oligonucleotides 59-75 angiotensinogen Homo sapiens 84-89 10906152-11 2000 Transient transfection with p44/42 MAP kinase antisense, but not sense, phosphorothioate-modified oligonucleotides also prevented AngII-induced MAP kinase phosphorylation, p27(Kip1) expression, and cell hypertrophy. Oligonucleotides 98-114 angiotensinogen Homo sapiens 130-135 12767723-4 2003 Blockade of the generation of HB-EGF by metalloprotease inhibitors, or abrogation of EGF receptor kinase activity by selective pharmacological inhibitors or antisense oligonucleotides, protects against Ang II-mediated cardiac hypertrophy. Oligonucleotides 167-183 angiotensinogen Homo sapiens 202-208 11967010-10 2002 Transfection of GMC with JAK2 antisense oligonucleotides blocked the Ang II-induced growth and collagen IV synthesis in both NG and HG conditions. Oligonucleotides 40-56 angiotensinogen Homo sapiens 69-75 9804857-3 1998 In the present study, we demonstrate using specific enzyme inhibitors and antisense oligonucleotides that both JAK2 and p59 Fyn tyrosine kinases are required for the Ang II-induced tyrosine phosphorylation and nuclear translocation of STAT1 in VSMCs. Oligonucleotides 84-100 angiotensinogen Homo sapiens 166-172 10600897-18 1999 Transfection with antisense oligonucleotides against ANGEN mRNA inhibited the subsequent induction of Fas-stimulated apoptosis by 70% in A549 cells and 87% in primary AECs (both P < 0.01). Oligonucleotides 28-44 angiotensinogen Homo sapiens 53-58 10027788-8 1999 Human AGT with a polyhistidine tag was able to repair the O6-pobG-containing DNA oligonucleotide, generating unmodified oligonucleotide. Oligonucleotides 81-96 angiotensinogen Homo sapiens 6-9 10027788-8 1999 Human AGT with a polyhistidine tag was able to repair the O6-pobG-containing DNA oligonucleotide, generating unmodified oligonucleotide. Oligonucleotides 120-135 angiotensinogen Homo sapiens 6-9 10391929-4 1999 In the present study, using specific enzyme inhibitors and antisense oligonucleotides, we show that Ang II-induced tyrosine phosphorylation and nuclear translocation of STAT3 in VSMCs is mediated by p60 c-Src, whereas tyrosine dephosphorylation is mediated by calcineurin. Oligonucleotides 69-85 angiotensinogen Homo sapiens 100-106 7782298-8 1995 A 51% reduction in IGF I receptor number following exposure to 5 microM antisense oligonucleotide markedly inhibited angiotensin II-induced mitogenesis. Oligonucleotides 82-97 angiotensinogen Homo sapiens 117-131 7582949-1 1995 It is shown by fluorescence spectroscopy that the post-activated form of neocarzinostatin chromophore (NCSi-glu) can form stable complexes with single-site oligonucleotides (SSOs) featuring sequences known to be involved in double stranded (AGC.GCT, AGT.ACT, AGA.TCT, ACA.TGT) or single stranded (AGG.CCT) cleavage (attacked residues in bold). Oligonucleotides 156-172 angiotensinogen Homo sapiens 250-253 1490071-2 1992 We demonstrated the presence of angiotensinogen (ANG) mRNA in cultured human mesangial cells (MC) and SHSY-5Y human neuroblastoma cells using reverse transcription and the polymerase chain reaction (RT/PCR) followed by hybridization to a human ANG-specific oligonucleotide probe. Oligonucleotides 257-272 angiotensinogen Homo sapiens 32-47 1490071-2 1992 We demonstrated the presence of angiotensinogen (ANG) mRNA in cultured human mesangial cells (MC) and SHSY-5Y human neuroblastoma cells using reverse transcription and the polymerase chain reaction (RT/PCR) followed by hybridization to a human ANG-specific oligonucleotide probe. Oligonucleotides 257-272 angiotensinogen Homo sapiens 49-52 1490071-6 1992 Growth of antisense oligonucleotide-treated cells was restored to control levels by the addition of AII but not by the addition of basic fibroblast growth factor. Oligonucleotides 20-35 angiotensinogen Homo sapiens 100-103