PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18243359-3	2008	The expression of AChE-R was blocked with a systemically administered central acting antisense oligonucleotide for AChE-R (EN101).	Oligonucleotides	95-110	acetylcholinesterase	Mus musculus	18-24	
25793201-0	2015	Corrigendum to "Presymptomatic treatment with acetylcholinesterase antisense oligonucleotides prolongs survival in ALS (G93A-SOD1) mice".	Oligonucleotides	77-93	acetylcholinesterase	Mus musculus	46-66	
24455732-0	2013	Presymptomatic treatment with acetylcholinesterase antisense oligonucleotides prolongs survival in ALS (G93A-SOD1) mice.	Oligonucleotides	61-77	acetylcholinesterase	Mus musculus	30-50	
24455732-2	2013	AChE enzyme inhibitors can upregulate AChE transcription which in certain contexts can have deleterious (noncatalytic) effects, making them theoretically harmful in ALS, whilst AChE antisense-oligonucleotides (mEN101), which downregulate AChE may be beneficial.	Oligonucleotides	192-208	acetylcholinesterase	Mus musculus	0-4	
24455732-2	2013	AChE enzyme inhibitors can upregulate AChE transcription which in certain contexts can have deleterious (noncatalytic) effects, making them theoretically harmful in ALS, whilst AChE antisense-oligonucleotides (mEN101), which downregulate AChE may be beneficial.	Oligonucleotides	192-208	acetylcholinesterase	Mus musculus	38-42	
24455732-2	2013	AChE enzyme inhibitors can upregulate AChE transcription which in certain contexts can have deleterious (noncatalytic) effects, making them theoretically harmful in ALS, whilst AChE antisense-oligonucleotides (mEN101), which downregulate AChE may be beneficial.	Oligonucleotides	192-208	acetylcholinesterase	Mus musculus	38-42	
24455732-2	2013	AChE enzyme inhibitors can upregulate AChE transcription which in certain contexts can have deleterious (noncatalytic) effects, making them theoretically harmful in ALS, whilst AChE antisense-oligonucleotides (mEN101), which downregulate AChE may be beneficial.	Oligonucleotides	192-208	acetylcholinesterase	Mus musculus	38-42	
18243359-3	2008	The expression of AChE-R was blocked with a systemically administered central acting antisense oligonucleotide for AChE-R (EN101).	Oligonucleotides	95-110	acetylcholinesterase	Mus musculus	115-121	
14581933-4	2004	Selective downregulation of AChE-R mRNA and protein by antisense oligonucleotides abolished the stress-associated increase in AChE-R, the elevation of contextual fear and LTP in the hippocampal CA1 region.	Oligonucleotides	65-81	acetylcholinesterase	Mus musculus	28-32	
15852394-2	2005	We report that peripheral administration of the acetylcholinesterase inhibitors tacrine, rivastigmine, neostigmine, or EN101 (an antisense oligonucleotide directed at acetylcholinesterase messenger RNA) to mice significantly attenuated the production of interleukin-1beta in the hippocampus and blood, concomitantly with the reduction in acetylcholinesterase activity.	Oligonucleotides	139-154	acetylcholinesterase	Mus musculus	48-68	
15852394-2	2005	We report that peripheral administration of the acetylcholinesterase inhibitors tacrine, rivastigmine, neostigmine, or EN101 (an antisense oligonucleotide directed at acetylcholinesterase messenger RNA) to mice significantly attenuated the production of interleukin-1beta in the hippocampus and blood, concomitantly with the reduction in acetylcholinesterase activity.	Oligonucleotides	139-154	acetylcholinesterase	Mus musculus	167-187	
15852394-2	2005	We report that peripheral administration of the acetylcholinesterase inhibitors tacrine, rivastigmine, neostigmine, or EN101 (an antisense oligonucleotide directed at acetylcholinesterase messenger RNA) to mice significantly attenuated the production of interleukin-1beta in the hippocampus and blood, concomitantly with the reduction in acetylcholinesterase activity.	Oligonucleotides	139-154	acetylcholinesterase	Mus musculus	167-187	
14581933-4	2004	Selective downregulation of AChE-R mRNA and protein by antisense oligonucleotides abolished the stress-associated increase in AChE-R, the elevation of contextual fear and LTP in the hippocampal CA1 region.	Oligonucleotides	65-81	acetylcholinesterase	Mus musculus	126-130	
10854041-6	2000	2"-O-methyl-protected antisense oligonucleotides targeted to AChE mRNA suppressed feedback upregulation of AChE and ameliorated DFP-induced NMJ proliferation.	Oligonucleotides	32-48	acetylcholinesterase	Mus musculus	61-65	
10854041-6	2000	2"-O-methyl-protected antisense oligonucleotides targeted to AChE mRNA suppressed feedback upregulation of AChE and ameliorated DFP-induced NMJ proliferation.	Oligonucleotides	32-48	acetylcholinesterase	Mus musculus	107-111