PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11449369-4 2001 Here we describe distinct CpG-containing oligonucleotide sequences which, in contrast to previously described CpG ODN, induced high amounts of IFN-alpha and IFN-beta in peripheral blood mononuclear cells (PBMC). Oligonucleotides 41-56 interferon beta 1 Homo sapiens 157-165 8662521-4 1996 Human monocytes transfected with pDNA or double-stranded oligonucleotides containing the ISS, but not those transfected with ISS-deficient pDNA or oligonucleotides, transcribed large amounts of interferon-alpha, interferon-beta, and interleukin-12. Oligonucleotides 57-73 interferon beta 1 Homo sapiens 212-227 6584908-4 1984 Using a synthetic oligonucleotide complementary to the human c-myc mRNA as the probe, we detected a more than 75% reduction in the c-myc hybridizable poly(A)+ RNA in the IFN-beta-treated cells. Oligonucleotides 18-33 interferon beta 1 Homo sapiens 170-178 1899864-10 1991 This IFN-gamma induced factor also binds to an oligonucleotide corresponding to -91 to -62 bp of the interferon-beta (IFN-beta) gene promoter, a region necessary for the induction of the IFN-beta gene by virus and double-stranded RNA. Oligonucleotides 47-62 interferon beta 1 Homo sapiens 101-116 1899864-10 1991 This IFN-gamma induced factor also binds to an oligonucleotide corresponding to -91 to -62 bp of the interferon-beta (IFN-beta) gene promoter, a region necessary for the induction of the IFN-beta gene by virus and double-stranded RNA. Oligonucleotides 47-62 interferon beta 1 Homo sapiens 118-126 1899864-10 1991 This IFN-gamma induced factor also binds to an oligonucleotide corresponding to -91 to -62 bp of the interferon-beta (IFN-beta) gene promoter, a region necessary for the induction of the IFN-beta gene by virus and double-stranded RNA. Oligonucleotides 47-62 interferon beta 1 Homo sapiens 187-195 2153928-6 1990 A synthetic double-stranded oligonucleotide corresponding to an authentic 30-base-pair (bp) region of the human IFN-beta promoter between positions -91 and -62 was found to confer virus inducibility upon the reporter CAT gene in HeLa cells. Oligonucleotides 28-43 interferon beta 1 Homo sapiens 112-120 2501084-8 1989 An oligonucleotide derived from the virus- and double-stranded RNA-inducible promoter of the interferon-beta 1 gene is able to bind IBP-1. Oligonucleotides 3-18 interferon beta 1 Homo sapiens 93-110 6159597-1 1980 From recently published data on the amino-terminal structures of human and mouse interferons, we have predicted and synthesised an oligonucleotide capable of priming specifically the reverse transcription of human fibroblast interferon mRNA present within a total mRNA population. Oligonucleotides 131-146 interferon beta 1 Homo sapiens 214-235 21877251-8 2011 Using oligonucleotide microarray, we demonstrated a dramatic increase in proinflammatory cytokine and chemokine transcripts (CXCL10, CXCL11, TNFSF10, CCL5, CCL4, CCL2, IFNB1, CCL20, IL-8, and CCL11). Oligonucleotides 6-21 interferon beta 1 Homo sapiens 168-173 21978158-6 2011 In particular, Lyn kinase oligonucleotides resulted in decreased expression of TLR-9-induced tumor necrosis factor alpha (TNF-alpha) but strongly upregulated canonical TLR-3-induced interferon beta (IFN-beta) and non-canonical TLR-3-induced NF-kappaB-dependent p35 (35kDa) subunit of interleukin 12 (IL-12p35) gene transcription. Oligonucleotides 26-42 interferon beta 1 Homo sapiens 182-197 21978158-6 2011 In particular, Lyn kinase oligonucleotides resulted in decreased expression of TLR-9-induced tumor necrosis factor alpha (TNF-alpha) but strongly upregulated canonical TLR-3-induced interferon beta (IFN-beta) and non-canonical TLR-3-induced NF-kappaB-dependent p35 (35kDa) subunit of interleukin 12 (IL-12p35) gene transcription. Oligonucleotides 26-42 interferon beta 1 Homo sapiens 199-207 19810673-2 2009 This study finds that the innate immune response (as measured by interferon-beta levels) to densely functionalized, oligonucleotide-modified nanoparticles is significantly less (up to a 25-fold decrease) when compared to a lipoplex carrying the same DNA sequence. Oligonucleotides 116-131 interferon beta 1 Homo sapiens 65-80 17273997-3 2007 TLR-3 and TLR-4 induce IFN-beta by activating IRF-3; TLR-9 induces IFN-alpha and IFN-beta through IRF-7, at least when engaged by type A CpG oligonucleotides (CpG-A) in plasmacytoid DC (pDC). Oligonucleotides 141-157 interferon beta 1 Homo sapiens 81-89 17273997-4 2007 In this issue of the European Journal of Immunology, it is demonstrated that TLR-9 induces IFN-beta when engaged by type B CpG oligonucleotides (CpG-B) in myeloid DC and macrophages. Oligonucleotides 127-143 interferon beta 1 Homo sapiens 91-99