PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25617889-9 2014 There was a negative correlation between total testosterone and carotid intima-media thickness (r=-0.656, p=0.008), and a negative correlation between total testosterone and leptin level (r=-0.794, p<0.001). Testosterone 157-169 leptin Homo sapiens 174-180 23666973-3 2013 OBJECTIVE: The objective of the study was to measure change in plasma estradiol and testosterone levels in postmenopausal women in relation to change in body mass index (BMI) and plasma leptin. Testosterone 84-96 leptin Homo sapiens 186-192 23666973-11 2013 CONCLUSIONS: In postmenopausal women, changes in BMI and plasma leptin occurring over several years are associated with changes in estradiol and testosterone levels. Testosterone 145-157 leptin Homo sapiens 64-70 24250904-8 2013 Spearman correlation coefficient showed that leptin had a significant negative correlation with the variability of testosterone (r = -1.00) in the healthy male group. Testosterone 115-127 leptin Homo sapiens 45-51 23919188-0 2013 Serum leptin level in women with polycystic ovary syndrome: correlation with adiposity, insulin, and circulating testosterone. Testosterone 113-125 leptin Homo sapiens 6-12 23919188-5 2013 AIM: Present investigation attempts to evaluate the interrelationship between serum leptin level with body mass index, insulin and with circulating testosterone in PCOS women. Testosterone 148-160 leptin Homo sapiens 84-90 21777525-9 2011 Leptin showed a significant positive correlation with LH (p < 0.01) and FSH (p < 0.002) and a significant negative correlation with testosterone (p < 0.001). Testosterone 138-150 leptin Homo sapiens 0-6 22616653-11 2012 Leptin and L/A correlated similarly with several parameters (negatively with testosterone/estradiol ratio and positively with BMI, insulin, HOMA-IR, and 17-beta estradiol). Testosterone 77-89 leptin Homo sapiens 0-6 21164276-9 2011 The main predictors of leptin level are BMI and the testosterone/estrone ratio in both sexes (p<0.05). Testosterone 52-64 leptin Homo sapiens 23-29 25493169-10 2012 Serum levels of leptin correlated with BMI (r=0.85, p<0.001), waist to hip ratio (WHR) (r=0.55, p<0.01), insulin levels (r=0.85, p<0.001) and HOMA-IR (r=0.67, p<0.01), while ghrelin levels had an inverse association with testosterone (r=-0.32, p=0.04). Testosterone 233-245 leptin Homo sapiens 16-22 21777525-11 2011 Providing a link between leptin and reproduction factors contributing in control of testosterone and gonadotropins secretion in many aspects depending on fertility status in male subjects. Testosterone 84-96 leptin Homo sapiens 25-31 21176234-11 2010 With multiple regression analysis BMI, FSH, LH, testosterone and ghrelin remained independently correlated with leptin while BMI, LH and testosterone remained independently correlated with ghrelin. Testosterone 48-60 leptin Homo sapiens 112-118 19476935-9 2010 Leptin was positively correlated with testosterone, free testosterone index, and free estrogen index and inversely associated with levels of sex hormone-binding globulin. Testosterone 38-50 leptin Homo sapiens 0-6 19476935-9 2010 Leptin was positively correlated with testosterone, free testosterone index, and free estrogen index and inversely associated with levels of sex hormone-binding globulin. Testosterone 57-69 leptin Homo sapiens 0-6 18547340-2 2009 Therefore, among the hormones involved in bone and mineral metabolism, such as oestrogens, testosterone and parathormone, leptin has recently become a subject of considerable interest. Testosterone 91-103 leptin Homo sapiens 122-128 18331605-12 2008 We observed inverse associations of log active ghrelin with testosterone (P = 0.01), and positive associations of leptin with testosterone and log E(2) (P = 0.02 and 0.009). Testosterone 126-138 leptin Homo sapiens 114-120 19995720-7 2009 After treatment statistically significant decrease in leptin concentration was obtained in the patients with BMI<or=25, insulin-sensitive patients (HOMA<3.8) and patients whose testosterone and androstendion concentrations stayed within normal limits. Testosterone 183-195 leptin Homo sapiens 54-60 18805913-3 2008 Studies suggest that testosterone replacement therapy may improve insulin sensitivity and glycaemic control in men with DM2 and reduces central obesity and serum leptin. Testosterone 21-33 leptin Homo sapiens 162-168 17209884-0 2007 Leptin levels in infertile male patients are correlated with inhibin B, testosterone and SHBG but not with sperm characteristics. Testosterone 72-84 leptin Homo sapiens 0-6 17950108-10 2007 Although there was a strong trend toward a correlation between both mean 24-hour serum leptin concentration and leptin secretory burst mass with the serum testosterone concentration in normal women, such trends were not seen in PCOS women. Testosterone 155-167 leptin Homo sapiens 87-93 17950108-10 2007 Although there was a strong trend toward a correlation between both mean 24-hour serum leptin concentration and leptin secretory burst mass with the serum testosterone concentration in normal women, such trends were not seen in PCOS women. Testosterone 155-167 leptin Homo sapiens 112-118 17714215-7 2007 Serum leptin demonstrated significant positive correlation with age, body weight, BMI and significant inverse correlation with serum testosterone. Testosterone 133-145 leptin Homo sapiens 6-12 17209884-5 2007 After adjustment for body mass index, there was a negative correlation between serum levels of leptin and inhibin B, total testosterone and SHBG (r = -0.189, p = 0.009, r = -0.250, p = 0.001 and r =-0.221, p = 0.003 respectively) but there was no correlation between leptin and classical sperm characteristics. Testosterone 123-135 leptin Homo sapiens 95-101 17212806-1 2007 The aim of our study was to investigate the relationships between the expression of leptin, leptin receptor in the testis and spermatogenesis, and testosterone (T) concentration in infertile men. Testosterone 147-159 leptin Homo sapiens 84-90 18320865-7 2007 A significant correlation was observed between BMI and androgens (both P < 0.01), and between leptin levels and androgens (respectfully for androstenendione P < 0.01 and for testosterone P < 0.05). Testosterone 180-192 leptin Homo sapiens 97-103 29699212-6 2005 Serum leptin was positively correlated with body mass index, percentage of body fat, serum levels of dehydroepiandrosterone sulfate, testosterone, free testosterone, luteinizing hormone and prolactin. Testosterone 133-145 leptin Homo sapiens 6-12 16448711-7 2006 From the present study it may be concluded that the positive relationship of leptin with insulin secretion and the negative one with testosterone, indicate direct implications of leptin in insulin signaling, as well as in male sexual development. Testosterone 133-145 leptin Homo sapiens 179-185 16249289-5 2006 RESULTS: In boys, priming with testosterone increased testosterone to pubertal levels (23.7 +/- 7.1 nmol/liter), which in turn induced a marked decrease in ghrelin (from 1615.8 +/- 418.6 to 1390.0 +/- 352.0 pg/ml) and leptin (from 8.0 +/- 4.5 to 5.8 +/- 3.2 ng/ml) and an increase in IGF-I (from 162.7 +/- 52.8 to 291.1 +/- 101.6 ng/ml) (P < 0.001 for all parameters). Testosterone 31-43 leptin Homo sapiens 218-224 16377941-2 2005 Cortisol causes blood leptin levels to rise and testosterone has an inverse relationship with blood leptin levels. Testosterone 48-60 leptin Homo sapiens 100-106 17142136-7 2006 By multiple regression analysis, leptin concentration was predicted by age (P < .05), testosterone (P < .05), adiponectin (P < .05), CRP (P < .01), and interleukin 6 receptor (P < .01). Testosterone 89-101 leptin Homo sapiens 33-39 17145648-8 2006 This effect was observed when treatment with recombinant human leptin spanned from 12 to 72 h. At this time an increase in testosterone levels was observed in leptin-treated cells versus placebo. Testosterone 123-135 leptin Homo sapiens 63-69 17145648-8 2006 This effect was observed when treatment with recombinant human leptin spanned from 12 to 72 h. At this time an increase in testosterone levels was observed in leptin-treated cells versus placebo. Testosterone 123-135 leptin Homo sapiens 159-165 16793964-13 2006 Finally, leptin was inversely correlated with total testosterone and SHBG (r = -0.44, P < 0.001; r = -0.30, P < 0.001 respectively); the relation with testosterone remained significant after adjustment for BMI. Testosterone 52-64 leptin Homo sapiens 9-15 16793964-13 2006 Finally, leptin was inversely correlated with total testosterone and SHBG (r = -0.44, P < 0.001; r = -0.30, P < 0.001 respectively); the relation with testosterone remained significant after adjustment for BMI. Testosterone 157-169 leptin Homo sapiens 9-15 17441374-0 2006 [Leptin correlates with distribution of fatty tissue and plasma levels of insulin, testosterone and tumor necrosis factor alpha in perimenopausal women with increased testosterone level and central location of body fat]. Testosterone 83-95 leptin Homo sapiens 1-7 17441374-0 2006 [Leptin correlates with distribution of fatty tissue and plasma levels of insulin, testosterone and tumor necrosis factor alpha in perimenopausal women with increased testosterone level and central location of body fat]. Testosterone 167-179 leptin Homo sapiens 1-7 17441374-1 2006 AIM: The evaluation of the influence of testosterone and fat tissue distribution on the serum leptin levels in perimenopausal women. Testosterone 40-52 leptin Homo sapiens 94-100 17441374-15 2006 CONCLUSION: The serum leptin level was linked to WHR, serum testosterone, insulin, TNF-alpha levels only in groups of perimenopausal women with such cardiovascular risk factors as high WHR, overweight, high serum TNF-alpha and testosterone levels. Testosterone 60-72 leptin Homo sapiens 22-28 17441374-15 2006 CONCLUSION: The serum leptin level was linked to WHR, serum testosterone, insulin, TNF-alpha levels only in groups of perimenopausal women with such cardiovascular risk factors as high WHR, overweight, high serum TNF-alpha and testosterone levels. Testosterone 227-239 leptin Homo sapiens 22-28 16821206-20 2005 In the group B insulin alone accounted for 39% (p<0.05) and together with testosterone accounted for 46% (p<0.05) of plasma leptin variance. Testosterone 77-89 leptin Homo sapiens 130-136 16377941-13 2005 However, delta serum testosterone was positively correlated with delta plasma leptin (r=596, p<0.05). Testosterone 21-33 leptin Homo sapiens 78-84 16377941-14 2005 Plasma leptin concentrations might modulate the secretion of testosterone in overtraining conditions. Testosterone 61-73 leptin Homo sapiens 7-13 16149684-8 2005 Serum leptin in males was independently related to BMD at L2-4 (r = -0.36, p < 0.05) and the femoral neck (r = -0.32, p < 0.05) in a multiple linear regression model with age, body mass index (BMI), serum free testosterone, estradiol and leptin as independent variables. Testosterone 216-228 leptin Homo sapiens 6-12 29699212-6 2005 Serum leptin was positively correlated with body mass index, percentage of body fat, serum levels of dehydroepiandrosterone sulfate, testosterone, free testosterone, luteinizing hormone and prolactin. Testosterone 152-164 leptin Homo sapiens 6-12 12970378-5 2003 In men, the decline in testosterone leads to an increase in leptin and a loss of lean mass. Testosterone 23-35 leptin Homo sapiens 60-66 12883384-5 2003 Indices of free testosterone showed an inverse linear correlation with leptin (P<0.01), and a strong drop in the 5th quintile of BMI. Testosterone 16-28 leptin Homo sapiens 71-77 12950408-3 2003 It was demonstrated that semen leptin concentrations were inversely correlated with serum testosterone levels and directly with serum leptin concentrations. Testosterone 90-102 leptin Homo sapiens 31-37 12950408-6 2003 Our data suggest that dysfunction of testicular epithelia as found in hypergonadotrophic hypogonadism and high-grade oligozoospermia with decreased testosterone levels causes elevated spermal leptin concentrations. Testosterone 148-160 leptin Homo sapiens 192-198 12629349-9 2003 CONCLUSION: Leptin may have roles in the development of prostate cancer through testosterone and factors related to obesity. Testosterone 80-92 leptin Homo sapiens 12-18 14515011-2 2003 High-intensity exercise is known to increase testosterone, an inhibitor of leptin. Testosterone 45-57 leptin Homo sapiens 75-81 14515011-3 2003 The objective of the study was to determine whether the leptin responses to a progressive, intermittent exercise protocol were related to serum testosterone concentrations. Testosterone 144-156 leptin Homo sapiens 56-62 12554610-11 2003 CONCLUSIONS: Serum leptin levels are related to many factors, e.g. fat mass, age, smoking, serum testosterone and oestradiol levels, growth factors such as IGF-1 and CRP, and cytokines, such as IL-6 and sTNFRII. Testosterone 97-109 leptin Homo sapiens 19-25 14664414-6 2003 It was found that: (a) there was a significant interaction between BMI and PCOS in increasing serum leptin levels; (b) the dominant factor for serum leptin levels in women of all Groups was BMI, followed by insulin; (c) once we corrected for BMI, it was found that there was a significant correlation between serum leptin levels and insulin values, as well as between serum leptin levels and testosterone concentrations; and (d) the QUICKI IR formula presented the most significant correlation with serum leptin levels than the other measures of insulin sensitivity. Testosterone 392-404 leptin Homo sapiens 149-155 15106467-12 2003 The decrease of serum leptin in women without any changes in men could have been mediated by gender differences in body fat tissue as well as hormonal (influence of catecholamins, cortisol, thyroid hormones and growth hormone on adipose tissue, augmentation of testosterone in men) and peripheral mechanisms (decrease of glucose or insulin and increase of fatty acids). Testosterone 261-273 leptin Homo sapiens 22-28 12718369-6 2003 Prior to and on hydrocortisone treatment in CAH, serum leptin levels were positively correlated with cortisol (r:0.78, p:0.004 and r:0.80, p:0.003) but negatively correlated with testosterone (r:-0.62, p:0.04 and r:-0.65, p:0.002). Testosterone 179-191 leptin Homo sapiens 55-61 12374466-4 2002 Moreover, in adipose tissue of women, the estrogen precursors testosterone (100 nM) and dehydroepiandrosterone (1 microM) also induced an increase in leptin secretion (+84 and +96%, respectively), an effect that was prevented by the aromatase inhibitor letrozole. Testosterone 62-74 leptin Homo sapiens 150-156 12414867-10 2002 Leptin levels were negatively and significantly correlated with free testosterone and total testosterone levels both before (r = -0.656, P = 0.011; and r = -0.639, P = 0.014, respectively) and after (r = -0.537, P = 0.048; and r = -0.563, P = 0.036, respectively) gonadotropin administration. Testosterone 69-81 leptin Homo sapiens 0-6 12414867-10 2002 Leptin levels were negatively and significantly correlated with free testosterone and total testosterone levels both before (r = -0.656, P = 0.011; and r = -0.639, P = 0.014, respectively) and after (r = -0.537, P = 0.048; and r = -0.563, P = 0.036, respectively) gonadotropin administration. Testosterone 92-104 leptin Homo sapiens 0-6 12414867-12 2002 Moreover, testosterone produced under the influence of the gonadotropin treatment led to decreases in the leptin levels. Testosterone 10-22 leptin Homo sapiens 106-112 12355336-1 2002 OBJECTIVE: To investigate the leptin and TNF systems in relation to testosterone in insulin resistant myotonic dystrophy (DM1) subjects. Testosterone 68-80 leptin Homo sapiens 30-36 12220230-2 2002 Recent research has suggested that leptin may also have an effect on testosterone secretion. Testosterone 69-81 leptin Homo sapiens 35-41 14664414-6 2003 It was found that: (a) there was a significant interaction between BMI and PCOS in increasing serum leptin levels; (b) the dominant factor for serum leptin levels in women of all Groups was BMI, followed by insulin; (c) once we corrected for BMI, it was found that there was a significant correlation between serum leptin levels and insulin values, as well as between serum leptin levels and testosterone concentrations; and (d) the QUICKI IR formula presented the most significant correlation with serum leptin levels than the other measures of insulin sensitivity. Testosterone 392-404 leptin Homo sapiens 149-155 14664414-6 2003 It was found that: (a) there was a significant interaction between BMI and PCOS in increasing serum leptin levels; (b) the dominant factor for serum leptin levels in women of all Groups was BMI, followed by insulin; (c) once we corrected for BMI, it was found that there was a significant correlation between serum leptin levels and insulin values, as well as between serum leptin levels and testosterone concentrations; and (d) the QUICKI IR formula presented the most significant correlation with serum leptin levels than the other measures of insulin sensitivity. Testosterone 392-404 leptin Homo sapiens 149-155 14664414-6 2003 It was found that: (a) there was a significant interaction between BMI and PCOS in increasing serum leptin levels; (b) the dominant factor for serum leptin levels in women of all Groups was BMI, followed by insulin; (c) once we corrected for BMI, it was found that there was a significant correlation between serum leptin levels and insulin values, as well as between serum leptin levels and testosterone concentrations; and (d) the QUICKI IR formula presented the most significant correlation with serum leptin levels than the other measures of insulin sensitivity. Testosterone 392-404 leptin Homo sapiens 149-155 12105281-2 2002 We have shown that this sexual dimorphism has a strong genetic component arising from a genotype by sex interaction, but adjusting leptin levels for testosterone eliminates this interaction. Testosterone 149-161 leptin Homo sapiens 131-137 12105281-6 2002 DISCUSSION: Given these results, we hypothesize that a QTL on chromosome 22 may influence the level of leptin adjusted for testosterone. Testosterone 123-135 leptin Homo sapiens 103-109 11786597-0 2002 Leptin"s sexual dimorphism results from genotype by sex interactions mediated by testosterone. Testosterone 81-93 leptin Homo sapiens 0-6 11916618-0 2002 Testosterone substitution of hypogonadal men prevents the age-dependent increases in body mass index, body fat and leptin seen in healthy ageing men: results of a cross-sectional study. Testosterone 0-12 leptin Homo sapiens 115-121 11916618-2 2002 In order to elucidate whether a causal relationship between these phenomena exists, we investigated the influence of testosterone or human chorionic gonadotrophin substitution on body mass index (BMI), total fat mass and serum leptin in testosterone-treated and untreated hypogonadal patients in comparison with ageing eugonadal men. Testosterone 237-249 leptin Homo sapiens 227-233 11916618-6 2002 RESULTS: In eugonadal men, serum testosterone levels decreased with advancing age (correlation coefficients: r=-0.71; P<0.0001), while BMI (r=0.39; P=0.002), total fat content (r=0.51; P<0.0001) and leptin (r=0.48; P<0.0001) increased significantly. Testosterone 33-45 leptin Homo sapiens 205-211 11911940-6 2002 Leptin appears to act as a direct inhibitory signal for testicular steroidogenesis, which may be relevant to explain the link between decreased testosterone secretion and hyperleptinaemia in obese men. Testosterone 144-156 leptin Homo sapiens 0-6 11911940-7 2002 Analysis of the molecular basis for leptin-induced inhibition of testosterone secretion revealed the potential involvement of decreased gene expression of several up-stream factors (e.g. SF-1, StAR and P450scc) in the steroidogenic pathway. Testosterone 65-77 leptin Homo sapiens 36-42 11915586-1 2002 The aim of this study was to monitor serum leptin concentrations after altering the levels of testosterone, by intramuscular administration of human chorionic gonadotropin (hCG), in eugonadal men. Testosterone 94-106 leptin Homo sapiens 43-49 11380502-2 2001 It has been shown that sex steroid hormones, in particular testosterone, play an important role in the regulation of serum leptin levels. Testosterone 59-71 leptin Homo sapiens 123-129 11469718-6 2001 Several hormones, including insulin, glucocorticoids, estradiol, growth hormone, testosterone, somatostatin, and insulin-like growth factor-I also modulate leptin secretion. Testosterone 81-93 leptin Homo sapiens 156-162 11730241-6 2001 The decline in testosterone levels in older males leads to increased leptin levels and this may explain the greater decline in food intake with aging in the male. Testosterone 15-27 leptin Homo sapiens 69-75 11454513-6 2001 In all patients leptin was significantly related to body mass index, fat mass and the homeostasis model insulin resistance index; moreover we observed a significant relationship with fasting plasma glucose and age in diabetic obese women, and with blood pressure values and testosterone concentrations in diabetic obese men. Testosterone 274-286 leptin Homo sapiens 16-22 11415851-7 2001 A positive correlation was found for both oestradiol and testosterone versus leptin in girls throughout puberty (r=0.64 and r=0.71 respectively, P<0.001). Testosterone 57-69 leptin Homo sapiens 77-83 11415851-8 2001 A negative correlation was found between leptin and testosterone in boys in mid- and late puberty (r=-0.66, P<0.01). Testosterone 52-64 leptin Homo sapiens 41-47 11443155-7 2001 Leptin increments were paralleled by increments of gonadotropins, testosterone, and the free androgen index (FAI). Testosterone 66-78 leptin Homo sapiens 0-6 11443155-8 2001 In each of the patients, serum concentrations of leptin were positively correlated with those of testosterone (P = 0.0001, P = 0.01, P = 0.07, respectively) and FAI (P = 0.0001, P = 0.0001, P = 0.09, respectively). Testosterone 97-109 leptin Homo sapiens 49-55 11443155-9 2001 In addition, in the combined data set of all patients changes of leptin over time were positively correlated with changes in LH (P = 0.01), FSH (P = 0.0001), testosterone (P = 0.002), and FAI (P = 0.002). Testosterone 158-170 leptin Homo sapiens 65-71 11448592-3 2001 In addition, the decline in testosterone in males results in elevated leptin levels that increase the anorexia. Testosterone 28-40 leptin Homo sapiens 70-76 11380502-3 2001 We had the opportunity to examine the effects of acute and chronic changes in serum testosterone levels on serum leptin concentrations in two virilized females harbouring testosterone-secreting ovarian tumours, before and after curative surgery. Testosterone 84-96 leptin Homo sapiens 113-119 11380502-4 2001 Chronically elevated basal testosterone levels (46 nmol/l) were associated with suppressed serum leptin levels (1.46 microg/l and 2.56 microg/l) vs. 12 age- and BMI-matched healthy subjects 9.89 +/- 0.64 microg/l. Testosterone 27-39 leptin Homo sapiens 97-103 11380502-6 2001 High testosterone levels abolished the well known sexual dimorphism of serum leptin levels. Testosterone 5-17 leptin Homo sapiens 77-83 11022169-6 2000 It has been shown that leptin secretion by the adipocyte is partly regulated by other hormones, such as insulin, cortisol, and sex steroids, mainly testosterone. Testosterone 148-160 leptin Homo sapiens 23-29 11244464-0 2001 A strong association between biologically active testosterone and leptin in non-obese men and women is lost with increasing (central) adiposity. Testosterone 49-61 leptin Homo sapiens 66-72 11244464-2 2001 Experimental data support the idea that testosterone exerts a negative influence on leptin levels. Testosterone 40-52 leptin Homo sapiens 84-90 11244464-5 2001 In the present study we have characterized the relationship between biologically active testosterone and leptin after careful stratification for gender and adiposity. Testosterone 88-100 leptin Homo sapiens 105-111 11244464-10 2001 RESULTS: After adjustments for age, BMI and insulin, leptin levels were inversely correlated to testosterone levels in non-obese men (r=-0.56, P<0.01) and obese women (r=-0.48, P<0.05). Testosterone 96-108 leptin Homo sapiens 53-59 11244464-13 2001 The following factors were associated with leptin in a multivariate model: low levels of biologically active testosterone and SHBG in men with low and medium waist circumference, insulin in men with high waist circumference, high levels of testosterone and insulin in non-obese women, and BMI in obese women. Testosterone 109-121 leptin Homo sapiens 43-49 11244464-13 2001 The following factors were associated with leptin in a multivariate model: low levels of biologically active testosterone and SHBG in men with low and medium waist circumference, insulin in men with high waist circumference, high levels of testosterone and insulin in non-obese women, and BMI in obese women. Testosterone 240-252 leptin Homo sapiens 43-49 11244464-15 2001 Based on these results we suggest that the relation between testosterone and leptin contributes to the gender difference in circulating leptin levels. Testosterone 60-72 leptin Homo sapiens 77-83 11244464-15 2001 Based on these results we suggest that the relation between testosterone and leptin contributes to the gender difference in circulating leptin levels. Testosterone 60-72 leptin Homo sapiens 136-142 11227729-7 2001 In a multiple regression analysis only body mass index and testosterone significantly contributed to the variation of plasma leptin. Testosterone 59-71 leptin Homo sapiens 125-131 11227729-12 2001 Testosterone appears to play a significant role in the regulation of leptin secretion. Testosterone 0-12 leptin Homo sapiens 69-75 11702849-6 2001 Leptin is not only correlated to a series of endocrine parameters such as insulin, glucocorticoids, thyroid hormones, testosterone, but it also seems to be involved in mediating some endocrine mechanisms (onset of puberty, insulin secretion) and diseases (obesity, polycystic ovary syndrome). Testosterone 118-130 leptin Homo sapiens 0-6 11170133-3 2001 RESULTS: Men with high-volume disease exhibited higher leptin concentrations overall and after stratification by age, testosterone level, height, and body mass index (BMI). Testosterone 118-130 leptin Homo sapiens 55-61 11079816-7 2000 By univariate analyses, logarithmically transformed serum leptin levels correlated positively with bioavailable estrogen ([E] estradiol plus estrone) in postmenopausal women not on HRT, and negatively with total and bioavailable testosterone (T) levels in men. Testosterone 229-241 leptin Homo sapiens 58-64 10853711-0 2000 Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism. Testosterone 0-12 leptin Homo sapiens 29-35 10754484-6 2000 As reported previously by our group, human recombinant leptin(10(-9)-10(-7)M) significantly inhibited both basal and human chorionic gonadotrophin (hCG)-stimulated testosterone secretion in vitro. Testosterone 164-176 leptin Homo sapiens 55-61 10762293-0 2000 The negative association between serum free testosterone and leptin is dependent on insulin-like growth factor-binding protein 1 in healthy young and middle-aged men. Testosterone 44-56 leptin Homo sapiens 61-67 10762293-1 2000 OBJECTIVE: Previous studies have shown that serum levels of testosterone correlate negatively with leptin and positively with insulin-like growth factor binding protein 1 (IGFBP-1). Testosterone 60-72 leptin Homo sapiens 99-105 10762293-4 2000 RESULTS: Univariate analyses revealed that serum levels of leptin correlated negatively with serum free testosterone (r = - 0.42, P = 0.008) and with serum IGFBP-1 (r = - 0. Testosterone 104-116 leptin Homo sapiens 59-65 10762293-7 2000 The correlations between leptin and free testosterone and between leptin and IGFBP-1 remained significant after adjustement for the influences of BMI and insulin. Testosterone 41-53 leptin Homo sapiens 25-31 10762293-10 2000 CONCLUSION: Serum levels of free testosterone and IGFBP-1 correlate negatively with serum leptin in healthy nonobese men but this influence is dependent on the influence of IGFBP-1. Testosterone 33-45 leptin Homo sapiens 90-96 10592445-14 1999 Testosterone has been found to suppress leptin synthesis by adipocytes both in vivo and in vitro. Testosterone 0-12 leptin Homo sapiens 40-46 10599552-12 1999 A positive correlation was demonstrated between leptin and testosterone in PCOS (r = 0.461, p < 0.01). Testosterone 59-71 leptin Homo sapiens 48-54 10599552-22 1999 A positive correlation exists between leptin and BMI as well as between leptin and testosterone in women with PCOS. Testosterone 83-95 leptin Homo sapiens 72-78 10468969-9 1999 Serum (free) testosterone levels were negatively correlated with age and serum leptin, also after partialization for BMI: rank correlation coefficients vs. age and serum leptin, respectively, were - 0.20 (P < 0.001) and - 0.16 (P < 0.01) for total testosterone and - 0.60 (P < 0.001) and - 0.23 (P < 0.001) for free testosterone. Testosterone 13-25 leptin Homo sapiens 79-85 10468969-9 1999 Serum (free) testosterone levels were negatively correlated with age and serum leptin, also after partialization for BMI: rank correlation coefficients vs. age and serum leptin, respectively, were - 0.20 (P < 0.001) and - 0.16 (P < 0.01) for total testosterone and - 0.60 (P < 0.001) and - 0.23 (P < 0.001) for free testosterone. Testosterone 13-25 leptin Homo sapiens 170-176 10468969-9 1999 Serum (free) testosterone levels were negatively correlated with age and serum leptin, also after partialization for BMI: rank correlation coefficients vs. age and serum leptin, respectively, were - 0.20 (P < 0.001) and - 0.16 (P < 0.01) for total testosterone and - 0.60 (P < 0.001) and - 0.23 (P < 0.001) for free testosterone. Testosterone 254-266 leptin Homo sapiens 79-85 10468969-9 1999 Serum (free) testosterone levels were negatively correlated with age and serum leptin, also after partialization for BMI: rank correlation coefficients vs. age and serum leptin, respectively, were - 0.20 (P < 0.001) and - 0.16 (P < 0.01) for total testosterone and - 0.60 (P < 0.001) and - 0.23 (P < 0.001) for free testosterone. Testosterone 254-266 leptin Homo sapiens 79-85 10468969-10 1999 Dehydroepiandrosterone sulphate (DHEAS) and leptin levels emerged as significant independent correlates in a multiple linear regression model for total serum testosterone; BMI and serum insulin became highly significant correlates in the same model when leptin was omitted from the independent variables. Testosterone 158-170 leptin Homo sapiens 44-50 11228760-7 1999 Leptin correlated with testosterone in women with diabetes (Pearson correlation coefficient r = 0.495, p = 0.037) but not in diabetic men. Testosterone 23-35 leptin Homo sapiens 0-6 11228760-9 1999 However, testosterone and insulin were predictors of leptin changes in the non-diabetic subjects. Testosterone 9-21 leptin Homo sapiens 53-59 11228760-11 1999 CONCLUSIONS: These results suggest that apart from body adiposity, testosterone also influences leptin levels and that diabetes has a significant effect on this association. Testosterone 67-79 leptin Homo sapiens 96-102 10320818-7 1999 Furthermore, leptin modulation of stimulated testosterone secretion was evaluated by incubation of testicular samples with different doses of leptin in the presence of 10 IU human chorionic gonadotrophin (hCG). Testosterone 45-57 leptin Homo sapiens 13-19 9925904-0 1999 Postnatal changes of leptin levels in full-term and preterm neonates: their relation to intrauterine growth, gender and testosterone. Testosterone 120-132 leptin Homo sapiens 21-27 9925904-3 1999 Testosterone levels were determined simultaneously to explore a possible relationship between leptin and testosterone concentrations. Testosterone 105-117 leptin Homo sapiens 94-100 9925904-11 1999 An inverse relationship was found between leptin and testosterone level (r = -0.358, p < 0.01) and a positive correlation between leptin level and weight/height ratio (r = 0.674, p < 0.01). Testosterone 53-65 leptin Homo sapiens 42-48 9925904-13 1999 In preterm male infants serum leptin concentration increases with postnatal weight and testosterone may suppress leptin synthesis. Testosterone 87-99 leptin Homo sapiens 113-119 10076188-0 1999 Dihydrotestosterone, stanozolol, androstenedione and dehydroepiandrosterone sulphate inhibit leptin secretion in female but not in male samples of omental adipose tissue in vitro: lack of effect of testosterone. Testosterone 7-19 leptin Homo sapiens 93-99 10664525-7 2000 Changes in serum leptin were correlated with those seen in serum oestradiol, testosterone, LH, FSH, cortisol and aldosterone, which were determined earlier. Testosterone 77-89 leptin Homo sapiens 17-23 10561941-9 1999 In men, serum free testosterone was negatively associated with serum leptin (r = -0.36, P < 0.001) while there was no association between serum estradiol and leptin. Testosterone 19-31 leptin Homo sapiens 69-75 10468969-12 1999 Testosterone does not appear to be a major determinant of serum leptin in healthy men, while leptin does emerge as a negative correlate of serum testosterone. Testosterone 145-157 leptin Homo sapiens 93-99 10454100-6 1999 After adjusting for total body fat, fat-free mass and age, testosterone concentration was negatively associated with leptin levels in pubertal boys, while estradiol concentration was positively associated with leptin level in pubertal girls. Testosterone 59-71 leptin Homo sapiens 117-123 10454100-8 1999 Although other factors may be involved, sexual dimorphism in leptin concentrations during puberty appears to be partly due to a stimulatory effect of estradiol on leptin concentration in females and a suppressive effect of testosterone on leptin concentration in males. Testosterone 223-235 leptin Homo sapiens 61-67 10102250-9 1999 Leptin was not associated with serum estrone or hormone replacement therapy in the women, but had a significant, negative association with testosterone in the men that was independent of SAT, but not VAT. Testosterone 139-151 leptin Homo sapiens 0-6 10102250-13 1999 The sex difference in serum leptin is not due to estrogen, but may be partly explained by testosterone. Testosterone 90-102 leptin Homo sapiens 28-34 10102250-14 1999 Testosterone is negatively associated with leptin in men, but the association is confounded with VAT. Testosterone 0-12 leptin Homo sapiens 43-49 10364627-6 1999 RESULTS: Using linear regression modeling, serum leptin levels were inversely associated with testosterone and positively associated with estradiol and dehydroepiandrosterone sulfate, after adjustment for the other hormones and body mass index (BMI). Testosterone 94-106 leptin Homo sapiens 49-55 10364627-11 1999 CONCLUSION: Serum levels of leptin may be influenced by other endocrine factors, especially testosterone and estradiol, and may be positively associated with excess fat intake independently of obesity. Testosterone 92-104 leptin Homo sapiens 28-34 10592445-15 1999 The decline of leptin levels in late puberty in boys accompanies increased androgen production during that time and most likely reflects suppression of leptin by testosterone and a decrease in fat mass and relative increase in muscle mass during late puberty in males. Testosterone 162-174 leptin Homo sapiens 152-158 10592445-15 1999 The decline of leptin levels in late puberty in boys accompanies increased androgen production during that time and most likely reflects suppression of leptin by testosterone and a decrease in fat mass and relative increase in muscle mass during late puberty in males. Testosterone 162-174 leptin Homo sapiens 15-21 10090130-17 1999 These data seem to indicate that time more than increase in testosterone levels and testicular volume is the determinant of leptin decline at puberty. Testosterone 60-72 leptin Homo sapiens 124-130 11490597-6 1999 In men, testosterone inhibits leptin, and the fall in testosterone with age results in an increase in leptin concentrations. Testosterone 8-20 leptin Homo sapiens 30-36 11490597-6 1999 In men, testosterone inhibits leptin, and the fall in testosterone with age results in an increase in leptin concentrations. Testosterone 54-66 leptin Homo sapiens 102-108 9725824-6 1998 In multiple regression, the sum of skinfolds and free testosterone and estrogen levels accounted for 74% of the variance in leptin levels. Testosterone 54-66 leptin Homo sapiens 124-130 9568809-5 1998 A strongly inverse relationship of serum testosterone levels with serum leptin levels in boys (p = 0.0067) appeared to explain this effect of age. Testosterone 41-53 leptin Homo sapiens 72-78 9745436-0 1998 Inverse correlation between serum testosterone and leptin in men. Testosterone 34-46 leptin Homo sapiens 51-57 9745436-6 1998 We found that the serum leptin concentration correlated inversely (r = -0.39; P < 0.001) with that of testosterone in elderly men. Testosterone 105-117 leptin Homo sapiens 24-30 9745436-8 1998 The administration of testosterone to young men suppressed serum leptin from the pretreatment level of 3.4 +/- 1.4 to 1.9 +/- 0.6 micrograms/L during the therapy. Testosterone 22-34 leptin Homo sapiens 65-71 9745436-9 1998 After cessation of testosterone injections, serum leptin concentration returned back to the pretreatment level. Testosterone 19-31 leptin Homo sapiens 50-56 9745436-10 1998 It is concluded that testosterone has a suppressive effect on leptin production, as reflected by circulating levels of this hormone. Testosterone 21-33 leptin Homo sapiens 62-68 9973668-4 1998 Including IDDM females only, solely low IGF-1 and high testosterone/SHBG were associated with leptin (R2 = 0.39, p = 0.009). Testosterone 55-67 leptin Homo sapiens 94-100 9660087-0 1998 Effects of gonadotropin and testosterone treatments on plasma leptin levels in male patients with idiopathic hypogonadotropic hypogonadism and Klinefelter"s syndrome. Testosterone 28-40 leptin Homo sapiens 62-68 9618121-9 1998 Finally, serum insulin concentration was an independent hormonal determinant of circulating leptin concentrations, whereas serum testosterone was negatively associated with leptin only by bivariate analysis. Testosterone 129-141 leptin Homo sapiens 173-179 9543124-3 1998 These data suggest that testosterone either directly suppresses leptin levels or induces changes in body composition that result in lower leptin concentrations. Testosterone 24-36 leptin Homo sapiens 64-70 9543124-3 1998 These data suggest that testosterone either directly suppresses leptin levels or induces changes in body composition that result in lower leptin concentrations. Testosterone 24-36 leptin Homo sapiens 138-144 9543124-6 1998 In the boys, suppression of testosterone increased leptin levels, whereas resumption of puberty was associated with decreased leptin levels [3.5 +/- 0.8 vs. 9.5 +/- 3.1 ng/dL (P = 0.005) and 12.2 +/- 4.5 vs. 7.0 +/- 2.6 ng/dL (P = 0.012), respectively]. Testosterone 28-40 leptin Homo sapiens 51-57 9543124-9 1998 These serial observations during reversible pituitary-gonadal suppression suggest that testosterone decreases leptin concentrations, but that estrogen, at least in this childhood model, has no discernible effect. Testosterone 87-99 leptin Homo sapiens 110-116 9568809-7 1998 A higher testosterone level in boys appears to account for an age-related decline in serum leptin in boys and the overall lower levels in boys than in girls. Testosterone 9-21 leptin Homo sapiens 91-97 9466130-0 1997 Gender differences in serum leptin in obese people: relationships with testosterone, body fat distribution and insulin sensitivity. Testosterone 71-83 leptin Homo sapiens 28-34 9439533-8 1997 In simple regression analysis, serum leptin was related to both serum estradiol and testosterone. Testosterone 84-96 leptin Homo sapiens 37-43 8923878-8 1996 There were also positive correlations of leptin levels with free testosterone and insulin sensitivity in control women. Testosterone 65-77 leptin Homo sapiens 41-47 9284709-13 1997 IN CONCLUSION: 1) leptin appears to increase in both boys and girls before the appearance of other reproductive hormones related to puberty; 2) leptin levels in boys are always lower than in girls, although they increase with age until the age 10 yr; 3) leptin in boys declines about the time testosterone increases. Testosterone 293-305 leptin Homo sapiens 144-150 9284709-13 1997 IN CONCLUSION: 1) leptin appears to increase in both boys and girls before the appearance of other reproductive hormones related to puberty; 2) leptin levels in boys are always lower than in girls, although they increase with age until the age 10 yr; 3) leptin in boys declines about the time testosterone increases. Testosterone 293-305 leptin Homo sapiens 144-150 9284717-13 1997 In boys, but not in girls, there was an inverse correlation with testosterone concentrations (r = -0.43, P < 0.0001), which explained 10.5% of the variation of leptin levels in a multiple regression model. Testosterone 65-77 leptin Homo sapiens 163-169 9253326-0 1997 Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. Testosterone 0-12 leptin Homo sapiens 52-58 9177366-4 1997 When PCOS and control groups were analyzed together by univariate analysis, serum leptin was positively correlated with body mass index (BMI), body weight, serum insulin, serum triglyceride, and serum free testosterone concentrations. Testosterone 206-218 leptin Homo sapiens 82-88 9385530-6 1997 In conclusion, high serum leptin, insulin and testosterone levels together with reduced insulin sensitivity were found in obese PCOS women, suggesting that high leptin levels could be a characteristic of the obese PCOS phenotype. Testosterone 46-58 leptin Homo sapiens 161-167 9329351-9 1997 Testosterone administration in female subjects decreased median serum leptin levels from 5.6 to 2.6 ng/mL after 4 months and to 2.5 ng/mL after 12 months (P < 0.0001). Testosterone 0-12 leptin Homo sapiens 70-76 9329351-11 1997 In conclusion, these results indicate that sex steroid hormones, in particular testosterone, play an important role in the regulation of serum leptin levels. Testosterone 79-91 leptin Homo sapiens 143-149 9259579-4 1997 In a multiple regression analysis with age and body mass index (percent body fat) as fixed variables, it turned out that testosterone had a potent negative effect on serum leptin in boys, but not in girls. Testosterone 121-133 leptin Homo sapiens 172-178 9259579-5 1997 In vitro experiments using newly developed human adipocytes in primary culture showed that both testosterone and its biologically active metabolite dihydrotestosterone are able to reduce leptin secretion into the culture medium by up to 62%. Testosterone 96-108 leptin Homo sapiens 187-193 9259579-6 1997 Using a semiquantitative reverse transcriptase-PCR method, testosterone was found to suppress leptin mRNA to a similar extent. Testosterone 59-71 leptin Homo sapiens 94-100 9177386-5 1997 Leptin levels were significantly correlated with free testosterone (r = -0.14; P < 0.05), sex hormone-binding globulin (r = -0.26; P < 0.05), total testosterone (r = -0.32; P < 0.01), and cortisol (r = -0.09; P = NS). Testosterone 54-66 leptin Homo sapiens 0-6 9177386-5 1997 Leptin levels were significantly correlated with free testosterone (r = -0.14; P < 0.05), sex hormone-binding globulin (r = -0.26; P < 0.05), total testosterone (r = -0.32; P < 0.01), and cortisol (r = -0.09; P = NS). Testosterone 154-166 leptin Homo sapiens 0-6 8923878-9 1996 In women with PCOS, 13% and 9.5% exhibited higher than expected leptin concentrations with respect to free testosterone and insulin sensitivity, respectively. Testosterone 107-119 leptin Homo sapiens 64-70 8923878-11 1996 The data demonstrate that a substantial proportion of women with PCOS have leptin levels that are higher than expected for their BMI, free testosterone and insulin sensitivity. Testosterone 139-151 leptin Homo sapiens 75-81 35246515-6 2022 The results demonstrated that TME secretes leptin, which induces LSC differentiation and increases testosterone production. Testosterone 99-111 leptin Homo sapiens 43-49 32797473-6 2020 Serum leptin and high-selective C-reactive protein (hsCRP) levels in testosterone group decreased from 6.2+-1.4 to 4.0+-1.2 mug/L, P< 0.05, and from 1.4+-1.2 to 1.0+-1.0 mg/L, P< 0.05 after 12 months, respectively. Testosterone 69-81 leptin Homo sapiens 6-12 32797473-9 2020 CONCLUSIONS: Testosterone replacement in men with age-related hypogonadism causes a decrease in body mass index, fat mass, serum leptin and C-reactive protein levels, and increases serum adiponectin levels. Testosterone 13-25 leptin Homo sapiens 129-135 34213036-3 2022 METHODS: We test hypotheses that leptin is associated with testosterone, estradiol, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) within healthy Ache men, an indigenous nonindustrialized South American community using archived data. Testosterone 59-71 leptin Homo sapiens 33-39 34213036-4 2022 RESULTS: Archived data of serum FSH, LH, leptin, and salivary testosterone and estradiol levels collected from healthy Ache men (n = 17, mean age = 37.1 +- 14.2) on two separate days revealed leptin was correlated with FSH (D1 p = .07, D2 p = .009) and PM testosterone (TsalPM, D1 p = .05, D2 p = .05). Testosterone 62-74 leptin Homo sapiens 192-198 35412268-8 2022 In early-pubertal girls with obesity (not prepubertal girls), there was a positive correlation (p < 0.01) between leptin levels with LH, androstenedione and testosterone, and HOMA-IR with LH and testosterone levels. Testosterone 157-169 leptin Homo sapiens 114-120 35412268-8 2022 In early-pubertal girls with obesity (not prepubertal girls), there was a positive correlation (p < 0.01) between leptin levels with LH, androstenedione and testosterone, and HOMA-IR with LH and testosterone levels. Testosterone 195-207 leptin Homo sapiens 114-120 35246515-7 2022 Leptin"s effects on LSC differentiation and testosterone production, however, are inversely concentration-dependent: positive at low doses and negative at higher doses. Testosterone 44-56 leptin Homo sapiens 0-6 35246515-10 2022 Taken together, these findings identify leptin as a key paracrine factor released by cells within the TME that modulates LSC differentiation and testosterone release from mature Leydig cells, a finding with important clinical implications for TD. Testosterone 145-157 leptin Homo sapiens 40-46 29079670-5 2017 Multivariate regression analyses revealed that changes in leptin and vaspin levels between the follicular and the luteal phase are strongly related to changes in total testosterone levels. Testosterone 168-180 leptin Homo sapiens 58-64 35355566-11 2022 Serum leptin levels of the patients were correlated with the FSI, fasting plasma glucose (FPG), homeostasis model assessment of insulin resistance (HOMA-IR), body mass index (BMI), and total testosterone levels. Testosterone 191-203 leptin Homo sapiens 6-12 32364518-7 2020 Leptin levels were positively correlated with fasting glucose, fasting insulin, free testosterone levels and homeostatic model assessment of insulin resistance (HOMA-IR) values. Testosterone 85-97 leptin Homo sapiens 0-6 29460468-5 2018 Leptin is critical for puberty initiation and can also modulate testosterone synthesis by downregulating cAMP-dependent activation of steroidogenic genes expressions. Testosterone 64-76 leptin Homo sapiens 0-6 35102263-5 2022 The association between leptin and low testosterone could potentially be explained via the imbalanced leptin levels that results in higher estrogen levels, which further increases the aromatase activity. Testosterone 39-51 leptin Homo sapiens 24-30 35102263-5 2022 The association between leptin and low testosterone could potentially be explained via the imbalanced leptin levels that results in higher estrogen levels, which further increases the aromatase activity. Testosterone 39-51 leptin Homo sapiens 102-108 35102263-9 2022 Additionally, further studies are needed to establish the molecular mechanism behind leptin-modulated changes to testosterone in obese men. Testosterone 113-125 leptin Homo sapiens 85-91 34051590-5 2021 In the in vitro experiments, the addition of LEP combined with anti-LEPR antibodies strengthened LEPR signal transduction, and inhibited significantly testosterone production in cultured Leydig cells isolated from prepubertal gander testes. Testosterone 151-163 leptin Homo sapiens 45-48 33326704-8 2021 In males, leptin correlates negatively with testosterone levels (-0.263, p<0.001), showing a stronger correlation after adjusting by body mass index (BMI) (-0.424, p<0.001). Testosterone 44-56 leptin Homo sapiens 10-16 33326704-12 2021 CONCLUSION: The negative association between hs-CRP and testosterone concentrations observed in 12- to 16-year-old males seems to be related to leptin levels which are closely negatively related to testosterone levels in males independently of BMI. Testosterone 56-68 leptin Homo sapiens 144-150 33326704-12 2021 CONCLUSION: The negative association between hs-CRP and testosterone concentrations observed in 12- to 16-year-old males seems to be related to leptin levels which are closely negatively related to testosterone levels in males independently of BMI. Testosterone 198-210 leptin Homo sapiens 144-150 32205811-7 2020 Additionally, serum leptin levels have negative associations with serum testosterone levels and sperm parameters and positive associations with serum follicle-stimulating hormone and luteinizing hormone levels and abnormal sperm morphology. Testosterone 72-84 leptin Homo sapiens 20-26 33179018-0 2020 Association of Leptin with Total and Free Testosterone: Results from the National Health and Nutrition Examination Surveys. Testosterone 42-54 leptin Homo sapiens 15-21 33179018-2 2020 Leptin is a 16-kDa protein produced primarily by adipose tissue and, therefore, is positively associated with the amount of body fat and can affect testosterone (T) production. Testosterone 148-160 leptin Homo sapiens 0-6 33179018-3 2020 We hypothesized that increased leptin can be independently associated with low T. Materials and Methods: We performed a cross-sectional analysis of men from National Health and Nutrition Examination III database to evaluate the association of leptin with serum T and calculated free testosterone (cFT). Testosterone 283-295 leptin Homo sapiens 31-37 27798245-7 2017 RESULTS: Parameters, such as body mass index, insulin resistance (IR), and total testosterone, which may influence leptin levels were extracted. Testosterone 81-93 leptin Homo sapiens 115-121 28199868-16 2017 The association between SD, BMI, low levels of testosterone and high levels of leptin suggest that policies that lead to healthier diets and more active lifestyles can be beneficial at least, to male patients. Testosterone 47-59 leptin Homo sapiens 79-85 25611822-3 2016 Leptin, a modulator of the HPG-axis, may also influence testosterone in T1D. Testosterone 56-68 leptin Homo sapiens 0-6 25611822-4 2016 We hypothesized that IS and leptin would be associated with total testosterone (TT), and free androgen index (FAI) in adolescent males with T1D. Testosterone 66-78 leptin Homo sapiens 28-34 25611822-4 2016 We hypothesized that IS and leptin would be associated with total testosterone (TT), and free androgen index (FAI) in adolescent males with T1D. Testosterone 80-82 leptin Homo sapiens 28-34 25611822-10 2016 CONCLUSION: Leptin accounted for a significant proportion of the variability of testosterone in T1D. Testosterone 80-92 leptin Homo sapiens 12-18 24926913-10 2015 Body fat-adjusted leptin correlated with free bioavailable testosterone, but it was only significant in nonaddictive exercisers. Testosterone 59-71 leptin Homo sapiens 18-24 26205254-6 2015 Additional effects involve the homeostatic disruption of insulin, sex-hormone-binding-globulin, leptin and inhibin B, leading to diminished testosterone production and impairment to spermatogenesis. Testosterone 140-152 leptin Homo sapiens 96-102 25419396-12 2014 The seminal leptin had significantly negative correlation with sperm progressive motility and serum total testosterone. Testosterone 106-118 leptin Homo sapiens 12-18