PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26574916-8 2016 In vitro, testosterone increased expression of cell cycle regulators (cyclin D1, cyclin E, and cyclin-dependent kinase 2) and reduced p53 and p21, which enhanced hepatocyte viability. Testosterone 10-22 transformation related protein 53, pseudogene Mus musculus 134-137 32199951-6 2020 P53/JNK pathway blockade ameliorated the Cd-induced inhibition of steroidogenic acute regulatory protein (STAR) expression and testosterone synthesis. Testosterone 127-139 transformation related protein 53, pseudogene Mus musculus 0-3 28554727-0 2017 Testosterone modulates FoxO3a and p53-related genes to protect C2C12 skeletal muscle cells against apoptosis. Testosterone 0-12 transformation related protein 53, pseudogene Mus musculus 34-37 28554727-3 2017 Since we have observed that testosterone reduces p-p53 and maintains the inactive state of FoxO3a transcription factor, induced by H2O2, we analyzed if the hormone was exerting its antiapoptotic effect at transcriptional level, by modulating pro and antiapoptotic genes associated to them. Testosterone 28-40 transformation related protein 53, pseudogene Mus musculus 51-54 26703444-0 2016 Effect of testosterone on the regulation of p53 and p66Shc during oxidative stress damage in C2C12 cells. Testosterone 10-22 transformation related protein 53, pseudogene Mus musculus 44-47 26703444-4 2016 Testosterone treatment, prior to H2O2, reduces not only p53 phosphorylation but also p66Shc expression, activation and its mitochondrial localization, at the same time that it prevents the mPTP opening. Testosterone 0-12 transformation related protein 53, pseudogene Mus musculus 56-59 26703444-6 2016 Thus, the mPTP opening, p53, JNK and PKCbetaI activation, as well as p66Shc mRNA increase, induced by oxidative stress, were reduced by testosterone pretreatment. Testosterone 136-148 transformation related protein 53, pseudogene Mus musculus 24-27 18030663-6 2007 Results of western blot analysis showed that [6]-gingerol upregulated the testosterone depleted levels of p53 in mouse prostate and upregulated its downstream regulator Bax and further activated Caspase-9 and Caspase-3 in both LNCaP cells and in mouse prostate. Testosterone 74-86 transformation related protein 53, pseudogene Mus musculus 106-109