PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28286655-8 2017 Serum testosterone levels were significantly negatively correlated with inflammation (CRP r = -0.471, p = 0.001; IL-6 r = -0.516, p < 0.001) and endotoxaemia (LBP) after adjusting for serum LH levels (p = -0.317, p = 0.03). Testosterone 6-18 C-reactive protein Homo sapiens 86-89 30592706-8 2018 Low concentrations of total testosterone at baseline were significantly associated with high logHOMA-Ir at follow-up in a multivariable model including age, waist-hip ratio, physical activity, alcohol intake, smoking, LDL, CRP, hypertension, diabetes and logHOMA-Ir at baseline as covariates (beta = -0.096, P = 0.006). Testosterone 28-40 C-reactive protein Homo sapiens 223-226 29527997-11 2018 Serum testosterone levels were positively correlated with hand-grip strength (r = 0.445; P = .033) and serum albumin (r = 0.399; P = .05) and negatively correlated with serum C-reactive protein (r = -0.454; P = .05) and age. Testosterone 6-18 C-reactive protein Homo sapiens 175-193 29527997-14 2018 CONCLUSIONS: Serum testosterone level is correlated with hand-grip strength and C-reactive protein and albumin levels, which may indicate that testosterone affects nutritional status and inflammation in male renal transplant recipients. Testosterone 19-31 C-reactive protein Homo sapiens 80-98 29527997-14 2018 CONCLUSIONS: Serum testosterone level is correlated with hand-grip strength and C-reactive protein and albumin levels, which may indicate that testosterone affects nutritional status and inflammation in male renal transplant recipients. Testosterone 143-155 C-reactive protein Homo sapiens 80-98 28640164-7 2017 Inverse associations between CRP-total testosterone became stronger with BMI adjustment (beta = -0.20, 95% CI -0.40, -0.01). Testosterone 39-51 C-reactive protein Homo sapiens 29-32 28640164-9 2017 CONCLUSIONS: Prospective and systems epidemiological studies are needed to understand whether or not the cross-sectional associations we observed, independent of adiposity, between CRP-SHBG, CRP-total testosterone, and CRP-free estradiol, are causal. Testosterone 201-213 C-reactive protein Homo sapiens 191-194 28640164-9 2017 CONCLUSIONS: Prospective and systems epidemiological studies are needed to understand whether or not the cross-sectional associations we observed, independent of adiposity, between CRP-SHBG, CRP-total testosterone, and CRP-free estradiol, are causal. Testosterone 201-213 C-reactive protein Homo sapiens 191-194 23979817-6 2014 Serum total testosterone was inversely correlated with age (r = -0.32, p < 0.05), CRP (r = -0.31, p < 0.05), and IL-6 (r = -0.24, p < 0.05). Testosterone 12-24 C-reactive protein Homo sapiens 85-88 27234858-10 2016 There is a statistically significant negative correlation between serum total testosterone levels and CRP serum levels were found (R - 0.75; p<0.000002 Spearman"s correlation). Testosterone 78-90 C-reactive protein Homo sapiens 102-105 26772984-6 2016 Testosterone associated inversely with weight, the degree of inflammation (i.e. C-reactive protein concentration) and signs of a chronic infection. Testosterone 0-12 C-reactive protein Homo sapiens 80-98 26184426-7 2016 Upon testosterone treatment, C-reactive protein declined significantly. Testosterone 5-17 C-reactive protein Homo sapiens 29-47 26622051-14 2016 Testosterone treatment also caused a significant fall in circulating concentrations of free fatty acids, C-reactive protein, interleukin-1beta, tumor necrosis factor-alpha, and leptin (P < 0.05 for all). Testosterone 0-12 C-reactive protein Homo sapiens 105-123 26633088-5 2015 With the HUVECs, we found an appropriate E2/T ratio of 5:1 (5x10(-8) mol/L estradiol and 10(-8) mol/L testosterone), which has a significant anti-apoptotic effect on HUVECs by inducing a C-reactive protein. Testosterone 102-114 C-reactive protein Homo sapiens 187-205 25961255-10 2011 (vi) In the multivariate model, age, BMI and CRP were independent predictors of the strongest benefit of testosterone treatment on the metabolic syndrome. Testosterone 105-117 C-reactive protein Homo sapiens 45-48 24124163-5 2013 Higher concentrations of total (slope per one quintile in concentration, -0.18; p-trend, 0.001) and calculated free (slope, -0.13; p-trend, 0.03) testosterone were statistically significantly associated with lower concentrations of CRP, but not with WBC count. Testosterone 146-158 C-reactive protein Homo sapiens 232-235 24124163-6 2013 Men in the bottom quintile of total testosterone (<=3.3 ng/mL), who might be considered to have clinically low testosterone, were more likely to have elevated CRP (>=3 mg/L) compared with men in the top four quintiles (OR, 1.61; 95% CI, 1.00-2.61). Testosterone 36-48 C-reactive protein Homo sapiens 162-165 24124163-6 2013 Men in the bottom quintile of total testosterone (<=3.3 ng/mL), who might be considered to have clinically low testosterone, were more likely to have elevated CRP (>=3 mg/L) compared with men in the top four quintiles (OR, 1.61; 95% CI, 1.00-2.61). Testosterone 114-126 C-reactive protein Homo sapiens 162-165 23046736-6 2013 RESULTS: Across decreasing thirds of testosterone distribution, patients were incrementally older and CRP levels rose significantly. Testosterone 37-49 C-reactive protein Homo sapiens 102-105 22970699-9 2013 Free testosterone concentrations were positively related to age and negatively to BMI, HOMA-IR and CRP concentrations. Testosterone 5-17 C-reactive protein Homo sapiens 87-102 21617198-11 2012 The inverse association between testosterone levels and ESA doses persisted after multivariate adjustment for age, sex hormone-binding globulin, comorbidities, C-reactive protein and s-albumin but was lost after further adjustment for iron medication and hypochromic RBC. Testosterone 32-44 C-reactive protein Homo sapiens 160-178 22165675-12 2011 An inverse correlation between testosterone and CRP was demonstrated for the 3A/4A COPD subgroup. Testosterone 31-43 C-reactive protein Homo sapiens 48-51 22165675-13 2011 CONCLUSIONS: Levels of testosterone correlated to FEV1, hypoxemia and weakly to CRP. Testosterone 23-35 C-reactive protein Homo sapiens 80-83 21896895-4 2011 The subnormal testosterone concentrations are not related to glycosylated hemoglobin or duration of diabetes, but are associated with obesity, very high C-reactive protein concentrations, and mild anemia. Testosterone 14-26 C-reactive protein Homo sapiens 153-171 21239514-6 2011 In addition, testosterone was positively associated with CRP (P = 0.006), IL-6 (P = 0.001), and TNF-alpha (P = 0.0002). Testosterone 13-25 C-reactive protein Homo sapiens 57-60 20664179-10 2011 C-reactive protein during testosterone therapy had a significant association with HV at T6 (r = -0.786; p = 0.021). Testosterone 26-38 C-reactive protein Homo sapiens 0-18 20457506-10 2010 There was an inverse correlation between testosterone and CRP levels (P<0.01). Testosterone 41-53 C-reactive protein Homo sapiens 58-61 20001470-0 2010 Elevated high sensitivity C-reactive protein levels in aging men with low testosterone. Testosterone 74-86 C-reactive protein Homo sapiens 26-44 20001470-1 2010 OBJECTIVE: We examined baseline data from a lipid treatment study to assess the relationship between testosterone (T) and the cardiovascular inflammatory marker, high sensitivity C-reactive protein (hsCRP). Testosterone 101-113 C-reactive protein Homo sapiens 179-197 20457506-17 2010 Low testosterone was associated with decreased survival and correlated inversely with CRP levels, dyspnea, and insomnia. Testosterone 4-16 C-reactive protein Homo sapiens 86-89 19472103-6 2010 Levels of ALT (GPT) AST (GOT) and CRP had decreased significantly after one year of testosterone treatment. Testosterone 84-96 C-reactive protein Homo sapiens 34-37 20214724-13 2010 CONCLUSIONS: We have verified the prevalence of low testosterone levels in male patients with type 2 diabetes and have related them to variations in BMI, waist circumference, neuropathy, triglycerides, CRP, glucose, insulin and HOMA-IR, but not with an increase of SMI or PAD. Testosterone 52-64 C-reactive protein Homo sapiens 202-205 19769617-9 2010 RESULTS: An inverse association was observed, in both bivariate and multivariate analyses, between CRP and total testosterone, free testosterone and SHBG levels. Testosterone 113-125 C-reactive protein Homo sapiens 99-102 19769617-9 2010 RESULTS: An inverse association was observed, in both bivariate and multivariate analyses, between CRP and total testosterone, free testosterone and SHBG levels. Testosterone 132-144 C-reactive protein Homo sapiens 99-102 19769617-12 2010 CONCLUSIONS: A robust, inverse dose-response correlation between testosterone and SHBG levels with CRP levels provides further evidence of a potential role of androgens in inflammatory processes. Testosterone 65-77 C-reactive protein Homo sapiens 99-102 19143723-7 2009 Along with the improvement of the metabolic syndrome upon testosterone administration, there was also an improvement of the IPSS and of RBV of urine and CRP. Testosterone 58-70 C-reactive protein Homo sapiens 153-156 20092788-0 2009 Testosterone replacement therapy improves insulin sensitivity and decreases high sensitivity C-reactive protein levels in hypogonadotropic hypogonadal young male patients. Testosterone 0-12 C-reactive protein Homo sapiens 93-111 19491539-4 2009 Low testosterone concentrations in men with type 2 diabetes have also been related to a higher C-reactive protein concentrations, lower hematocrit, increased total and regional adiposity, lower bone mineral density, and erectile dysfunction. Testosterone 4-16 C-reactive protein Homo sapiens 95-113 19447426-5 2009 RESULTS: Calculated free testosterone and bioavailable testosterone were negatively related to International Prostate Symptom Score total scores and subscores (voiding symptoms) after adjusting for age, prostate volume, high sensitivity C-reactive protein and homeostasis model assessment of insulin resistance (p <0.05). Testosterone 25-37 C-reactive protein Homo sapiens 237-255 19447426-5 2009 RESULTS: Calculated free testosterone and bioavailable testosterone were negatively related to International Prostate Symptom Score total scores and subscores (voiding symptoms) after adjusting for age, prostate volume, high sensitivity C-reactive protein and homeostasis model assessment of insulin resistance (p <0.05). Testosterone 55-67 C-reactive protein Homo sapiens 237-255 19447426-7 2009 High sensitivity C-reactive protein was negatively correlated with serum total testosterone (r = -0.128, p = 0.038) and bioavailable testosterone (r = -0.126, p = 0.041), and homeostasis model assessment of insulin resistance was negatively correlated with serum total testosterone (r = -0.236, p <0.001), calculated free testosterone (r = -0.179, p = 0.003) and bioavailable testosterone (r = -0.162, r = 0.007). Testosterone 79-91 C-reactive protein Homo sapiens 17-35 19447426-7 2009 High sensitivity C-reactive protein was negatively correlated with serum total testosterone (r = -0.128, p = 0.038) and bioavailable testosterone (r = -0.126, p = 0.041), and homeostasis model assessment of insulin resistance was negatively correlated with serum total testosterone (r = -0.236, p <0.001), calculated free testosterone (r = -0.179, p = 0.003) and bioavailable testosterone (r = -0.162, r = 0.007). Testosterone 133-145 C-reactive protein Homo sapiens 17-35 19447426-7 2009 High sensitivity C-reactive protein was negatively correlated with serum total testosterone (r = -0.128, p = 0.038) and bioavailable testosterone (r = -0.126, p = 0.041), and homeostasis model assessment of insulin resistance was negatively correlated with serum total testosterone (r = -0.236, p <0.001), calculated free testosterone (r = -0.179, p = 0.003) and bioavailable testosterone (r = -0.162, r = 0.007). Testosterone 133-145 C-reactive protein Homo sapiens 17-35 19447426-7 2009 High sensitivity C-reactive protein was negatively correlated with serum total testosterone (r = -0.128, p = 0.038) and bioavailable testosterone (r = -0.126, p = 0.041), and homeostasis model assessment of insulin resistance was negatively correlated with serum total testosterone (r = -0.236, p <0.001), calculated free testosterone (r = -0.179, p = 0.003) and bioavailable testosterone (r = -0.162, r = 0.007). Testosterone 133-145 C-reactive protein Homo sapiens 17-35 19447426-7 2009 High sensitivity C-reactive protein was negatively correlated with serum total testosterone (r = -0.128, p = 0.038) and bioavailable testosterone (r = -0.126, p = 0.041), and homeostasis model assessment of insulin resistance was negatively correlated with serum total testosterone (r = -0.236, p <0.001), calculated free testosterone (r = -0.179, p = 0.003) and bioavailable testosterone (r = -0.162, r = 0.007). Testosterone 133-145 C-reactive protein Homo sapiens 17-35 18555838-9 2008 Median CRP levels were greater in the group with higher testosterone levels (1.17 [0.17-2.36] vs 0.17 [0.17-0.61] mg/L, P = .039). Testosterone 56-68 C-reactive protein Homo sapiens 7-10 19080648-1 2008 OBJECTIVE: To evaluate the effect of testosterone replacement therapy in patients with hypogonadotrophic hypogonadism (HH) on insulin sensitivity and high sensitivity C reactive protein (hsCRP). Testosterone 37-49 C-reactive protein Homo sapiens 167-185 19032692-0 2008 C-reactive protein levels and ageing male symptoms in hypogonadal men treated with testosterone supplementation. Testosterone 83-95 C-reactive protein Homo sapiens 0-18 19032692-5 2008 Testosterone administration resulted in a profound decline in CRP levels and AMS scores (both P < 0.001). Testosterone 0-12 C-reactive protein Homo sapiens 62-65 18821286-5 2008 C-reactive protein concentrations have been shown to be elevated in patients with HH and are inversely related to plasma testosterone concentrations. Testosterone 121-133 C-reactive protein Homo sapiens 0-18 18821286-6 2008 This inverse relationship between plasma free testosterone and C- reactive protein concentrations in patients with type 2 diabetes suggests that inflammation may play an important role in the pathogenesis of this syndrome. Testosterone 46-58 C-reactive protein Homo sapiens 63-82 18555838-11 2008 An association of testosterone with CRP (r = 0.416, P = .004) and ET-1 (r = 0.323, P = .031) was observed. Testosterone 18-30 C-reactive protein Homo sapiens 36-39 18035098-1 2007 BACKGROUND: To determine the effect of oral testosterone supplementation on systemic low-grade inflammation measured by high-sensitive C-reactive protein (hs-CRP) in aging men with low testosterone levels. Testosterone 44-56 C-reactive protein Homo sapiens 135-153 17971101-15 2008 High-dose testosterone administration appeared to increase weight, visceral fat, and hematocrit, decrease high-density lipoprotein cholesterol, increase endothelin-1, increase C-reactive protein, and increase total homocysteine. Testosterone 10-22 C-reactive protein Homo sapiens 176-194 17911176-8 2008 The low testosterone-mortality association was also independent of the metabolic syndrome, diabetes, and prevalent cardiovascular disease but was attenuated by adjustment for IL-6 and C-reactive protein. Testosterone 8-20 C-reactive protein Homo sapiens 184-202 16040142-15 2006 Statistical analysis revealed that testosterone treatment prior to stent implantation attenuated IL-6 and hs-CRP levels significantly (P=0.042 and P=0.043; respectively). Testosterone 35-47 C-reactive protein Homo sapiens 109-112 17468196-0 2007 The effect of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes. Testosterone 14-26 C-reactive protein Homo sapiens 69-87 17468196-4 2007 We examined the effects of testosterone replacement treatment on various adipocytokines and C-reactive protein (CRP) in type 2 diabetic men. Testosterone 27-39 C-reactive protein Homo sapiens 92-110 17468196-11 2007 CRP levels also correlated significantly with total testosterone levels (r=-0.59; P=0.01). Testosterone 52-64 C-reactive protein Homo sapiens 0-3 16040142-16 2006 CONCLUSIONS: The present study shows that 3 weeks testosterone treatment prior to intracoronary stenting results in a significant suppression in hs-CRP and IL-6 levels after the stent implantation. Testosterone 50-62 C-reactive protein Homo sapiens 148-151 16216530-0 2006 Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease. Testosterone 39-51 C-reactive protein Homo sapiens 82-100 16216530-9 2006 CONCLUSIONS: SHBG and total testosterone were inversely associated with CRP among HT nonusers in this study. Testosterone 28-40 C-reactive protein Homo sapiens 72-75 9605127-0 1998 Testosterone and IL-6 requirements for human C-reactive protein gene expression in transgenic mice. Testosterone 0-12 C-reactive protein Homo sapiens 45-63 16130198-14 2005 Correlation analysis showed that FT (free testosterone) had negative correlation with CRP, IL-6 and sICAM-1. Testosterone 42-54 C-reactive protein Homo sapiens 86-89 16417414-9 2006 The increment in CRP level between the highest and lowest quartile of bioavailable testosterone was 1.28 microg/mL. Testosterone 83-95 C-reactive protein Homo sapiens 17-20 14641004-4 2003 After categorisation by tertiles and adjusting for age and body mass index, total and free testosterone and SHBG were inversely associated with concentrations of insulin, glucose, triglycerides, C-reactive protein (CRP) and CRP-adjusted ferritin and positively associated with high-density lipoprotein cholesterol. Testosterone 91-103 C-reactive protein Homo sapiens 195-213 14641004-4 2003 After categorisation by tertiles and adjusting for age and body mass index, total and free testosterone and SHBG were inversely associated with concentrations of insulin, glucose, triglycerides, C-reactive protein (CRP) and CRP-adjusted ferritin and positively associated with high-density lipoprotein cholesterol. Testosterone 91-103 C-reactive protein Homo sapiens 215-218 14641004-4 2003 After categorisation by tertiles and adjusting for age and body mass index, total and free testosterone and SHBG were inversely associated with concentrations of insulin, glucose, triglycerides, C-reactive protein (CRP) and CRP-adjusted ferritin and positively associated with high-density lipoprotein cholesterol. Testosterone 91-103 C-reactive protein Homo sapiens 224-227 32797473-6 2020 Serum leptin and high-selective C-reactive protein (hsCRP) levels in testosterone group decreased from 6.2+-1.4 to 4.0+-1.2 mug/L, P< 0.05, and from 1.4+-1.2 to 1.0+-1.0 mg/L, P< 0.05 after 12 months, respectively. Testosterone 69-81 C-reactive protein Homo sapiens 32-50 9212359-4 1997 Studies using the same mice revealed a previously unknown testosterone-dependence of constitutive expression of human CRP. Testosterone 58-70 C-reactive protein Homo sapiens 118-121 32797473-9 2020 CONCLUSIONS: Testosterone replacement in men with age-related hypogonadism causes a decrease in body mass index, fat mass, serum leptin and C-reactive protein levels, and increases serum adiponectin levels. Testosterone 13-25 C-reactive protein Homo sapiens 140-158 34247541-3 2021 First, we conducted a cross-sectional study using the recently released 2015-2016 National Health and Nutrition Examination Survey (NHANES) data to examine the association between testosterone deficiency and inflammation biomarkers including high sensitivity C-reactive protein (hsCRP), liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the US general population. Testosterone 180-192 C-reactive protein Homo sapiens 259-277 33326704-3 2021 OBJECTIVES: To analyze the association between high sensitivity CRP (hs-CRP) and testosterone, estradiol and sex hormone binding globulin (SHBG) levels in a population-based sample of adolescents, and to evaluate the influence of leptin levels on this association. Testosterone 81-93 C-reactive protein Homo sapiens 64-67 34661247-7 2021 Spearman"s correlation analysis revealed that total testosterone levels were significantly and inversely correlated with NLR, high-sensitivity C-reactive protein (hsCRP), interleukin-6, D-dimer and PCT. Testosterone 52-64 C-reactive protein Homo sapiens 143-161 34994082-10 2022 A longer length of hospitalization and increased inflammatory markers (d-dimer, high-sensitive C-reactive protein, and procalcitonin) were detected in the low-free testosterone group. Testosterone 164-176 C-reactive protein Homo sapiens 95-113 33326704-3 2021 OBJECTIVES: To analyze the association between high sensitivity CRP (hs-CRP) and testosterone, estradiol and sex hormone binding globulin (SHBG) levels in a population-based sample of adolescents, and to evaluate the influence of leptin levels on this association. Testosterone 81-93 C-reactive protein Homo sapiens 72-75 33326704-9 2021 A significant correlation between hs-CRP and testosterone levels is observed in males after adjusting by BMI, but the correlation disappears after adjusting by leptin. Testosterone 45-57 C-reactive protein Homo sapiens 37-40 33326704-12 2021 CONCLUSION: The negative association between hs-CRP and testosterone concentrations observed in 12- to 16-year-old males seems to be related to leptin levels which are closely negatively related to testosterone levels in males independently of BMI. Testosterone 56-68 C-reactive protein Homo sapiens 48-51 33326704-12 2021 CONCLUSION: The negative association between hs-CRP and testosterone concentrations observed in 12- to 16-year-old males seems to be related to leptin levels which are closely negatively related to testosterone levels in males independently of BMI. Testosterone 198-210 C-reactive protein Homo sapiens 48-51 33647767-8 2021 In agreement with the known anti-inflammatory action of testosterone, patients with long-polyQ and age >=60 years had increased levels of CRP (p = 0.018, not accounting for multiple testing). Testosterone 56-68 C-reactive protein Homo sapiens 138-141 33838041-8 2021 Low total testosterone levels were correlated with lower high-density lipoprotein cholesterol and higher triglycerides, high-sensitivity C-reactive protein, high-sensitivity troponin T, N-terminal-pro B-type natriuretic peptide and glucose levels (all p < 0.01). Testosterone 10-22 C-reactive protein Homo sapiens 137-155 33063668-4 2020 Lifelong increased free testosterone had beneficial effects on increased bone mineral density, and decreased body fat; adverse effects on decreased HDL, and increased risks of prostate cancer, androgenic alopecia, spinal stenosis, and hypertension; and context-dependent effects on increased haematocrit and decreased C-reactive protein. Testosterone 24-36 C-reactive protein Homo sapiens 318-336 32219132-9 2020 Multiple linear regression analysis showed that CRP values are positively associated with BMI (beta = 0,374, p < 0,001) and insulin level (INS1) (beta = 0,282, p = 0,004); and WBC results are negatively associated with SHGB (beta = -0,284, p < 0,001) but positively associated with testosterone (beta = 0,163, p = 0,024) and BMI (beta = 0,157, p = 0,047). Testosterone 282-294 C-reactive protein Homo sapiens 48-51 31547562-15 2019 Additionally, after adjusting for BMI and total energy intake, testosterone levels showed significant negative correlations with PREDIMED score (p < 0.001) and consumption of protein (p = 0.005), complex carbohydrate (p < 0.001), fiber (p < 0.001), MUFA (p < 0.001), n-3 PUFA (p = 0.001), and positive associations with CRP levels, simple carbohydrate, SFA, n-6 PUFA (p < 0.001, respectively), and PUFA (p = 0.002). Testosterone 63-75 C-reactive protein Homo sapiens 332-335