PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19474060-12	2009	Our findings suggest that testosterone activates the mTORC1/S6K1 axis through IP(3)/Ca(2+) and MEK/ERK1/2 to induce cardiomyocyte hypertrophy.	Testosterone	26-38	ribosomal protein S6 kinase B1	Homo sapiens	60-64	
23316499-0	2013	Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells.	Testosterone	70-82	ribosomal protein S6 kinase B1	Homo sapiens	29-35	
19474060-5	2009	Testosterone increases the phosphorylation of mTOR and its downstream targets 40S ribosomal protein S6 kinase 1 (S6K1; also known as RPS6KB1) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1).	Testosterone	0-12	ribosomal protein S6 kinase B1	Homo sapiens	82-117	
19474060-5	2009	Testosterone increases the phosphorylation of mTOR and its downstream targets 40S ribosomal protein S6 kinase 1 (S6K1; also known as RPS6KB1) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1).	Testosterone	0-12	ribosomal protein S6 kinase B1	Homo sapiens	133-140	
23316499-5	2013	Pharmacological inhibition of FAK-sensitive phosphatidylinositide-3-kinase (PI-3K), a known element of mAR-signaling, fully abrogated the testosterone-induced actin reorganization and the activation of mTOR, p70S6K and PAK1.	Testosterone	138-150	ribosomal protein S6 kinase B1	Homo sapiens	208-214	
19474060-6	2009	The S6K1 phosphorylation induced by testosterone was blocked by rapamycin and small interfering RNA to mTOR.	Testosterone	36-48	ribosomal protein S6 kinase B1	Homo sapiens	4-8	
19474060-8	2009	ERK1/2 inhibitor PD98059 blocked the testosterone-induced S6K1 phosphorylation, whereas Akt inhibition (Akt-inhibitor-X) had no effect.	Testosterone	37-49	ribosomal protein S6 kinase B1	Homo sapiens	58-62	
19474060-9	2009	Testosterone-induced ERK1/2 and S6K1 phosphorylation increases were blocked by either 1,2-bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid-acetoxymethylester or by inhibitors of inositol 1,4,5-trisphosphate (IP(3)) pathway: U-73122 and 2-aminoethyl diphenylborate.	Testosterone	0-12	ribosomal protein S6 kinase B1	Homo sapiens	32-36	
25034385-8	2014	Acute stimulation of myotubes with testosterone reduced phosphorylation of S6K1 and p38 MAPK.	Testosterone	35-47	ribosomal protein S6 kinase B1	Homo sapiens	75-79	
25034385-13	2014	Furthermore, testosterone treatment elicits additional alterations in serine/threonine kinase signaling, including the ribosomal protein S6K1 and p38 MAPK.	Testosterone	13-25	ribosomal protein S6 kinase B1	Homo sapiens	137-141