PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35021306-3	2022	Animal models demonstrated that testosterone (T) exerted a neuroprotective effect reducing the production of amyloid-beta (Abeta), improving synaptic signaling, and counteracting neuronal death.	Testosterone	32-44	amyloid beta precursor protein	Homo sapiens	109-121	
35021306-3	2022	Animal models demonstrated that testosterone (T) exerted a neuroprotective effect reducing the production of amyloid-beta (Abeta), improving synaptic signaling, and counteracting neuronal death.	Testosterone	32-44	amyloid beta precursor protein	Homo sapiens	123-128	
25045655-0	2014	Protective effects of testosterone on presynaptic terminals against oligomeric beta-amyloid peptide in primary culture of hippocampal neurons.	Testosterone	22-34	amyloid beta precursor protein	Homo sapiens	79-99	
29505099-6	2018	In line with this finding, testosterone compared to estradiol was able to improve microglial viability and Abeta clearance in vitro.	Testosterone	27-39	amyloid beta precursor protein	Homo sapiens	107-112	
28692878-7	2017	These results suggest that testosterone might inhibit the early pathological accumulation of Abeta in females and delay neurodegeneration in males.	Testosterone	27-39	amyloid beta precursor protein	Homo sapiens	93-98	
26122291-0	2015	The impact of luteinizing hormone and testosterone on beta amyloid (Abeta) accumulation: Animal and human clinical studies.	Testosterone	38-50	amyloid beta precursor protein	Homo sapiens	54-74	
26122291-5	2015	Both testosterone and LH have been shown to modulate CNS Abeta accumulation in animal studies, and associations with cerebral amyloid load in human studies have supported this.	Testosterone	5-17	amyloid beta precursor protein	Homo sapiens	57-62	
26122291-7	2015	This review will discuss underlying mechanisms by which testosterone and LH modulate Abeta and provide an update on therapeutic approaches targeting these hormones.	Testosterone	56-68	amyloid beta precursor protein	Homo sapiens	85-90	
25045655-3	2014	Previous studies demonstrated that testosterone could alleviate neurotoxicity induced by beta-amyloid (Abeta), but these findings mainly focused on neuronal apoptosis.	Testosterone	35-47	amyloid beta precursor protein	Homo sapiens	103-108	
25045655-4	2014	Since synaptic dysfunction and degeneration are early events during the pathogenesis of AD, we aim to investigate the effects of testosterone on oligomeric Abeta-induced synaptic changes.	Testosterone	129-141	amyloid beta precursor protein	Homo sapiens	156-161	
25045655-10	2014	Furthermore, we showed that testosterone could attenuate Abeta-induced reduction of HSP70, which suggests a novel mechanism that links testosterone and its protective function on Abeta-induced synaptic damage.	Testosterone	28-40	amyloid beta precursor protein	Homo sapiens	57-62	
25045655-10	2014	Furthermore, we showed that testosterone could attenuate Abeta-induced reduction of HSP70, which suggests a novel mechanism that links testosterone and its protective function on Abeta-induced synaptic damage.	Testosterone	28-40	amyloid beta precursor protein	Homo sapiens	179-184	
25045655-10	2014	Furthermore, we showed that testosterone could attenuate Abeta-induced reduction of HSP70, which suggests a novel mechanism that links testosterone and its protective function on Abeta-induced synaptic damage.	Testosterone	135-147	amyloid beta precursor protein	Homo sapiens	57-62	
25045655-10	2014	Furthermore, we showed that testosterone could attenuate Abeta-induced reduction of HSP70, which suggests a novel mechanism that links testosterone and its protective function on Abeta-induced synaptic damage.	Testosterone	135-147	amyloid beta precursor protein	Homo sapiens	179-184	
19428144-8	2011	In male cases with mild neuropathological changes, we found an inverse relationship between brain levels of testosterone and soluble Abeta.	Testosterone	108-120	amyloid beta precursor protein	Homo sapiens	133-138	
23089633-1	2014	Testosterone and gonadotropins have been associated with cognitive decline in men and the modulation of beta amyloid (Abeta) metabolism.	Testosterone	0-12	amyloid beta precursor protein	Homo sapiens	118-123	
21953968-7	2011	In the current study, a rapid and sensitive liquid chromatography/positive atmospheric pressure photoionization tandem mass spectrometry method (LC/APPI-MS/MS) has been developed and validated for the simultaneous quantitation of testosterone and estradiol in the H295R cell line.	Testosterone	230-242	amyloid beta precursor protein	Homo sapiens	148-152