PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34274310-0	2021	Potential of ephedrine to suppress the gene expression of TNF-alpha, IL-1beta, IL-6 and PGE2: A novel approach towards management of rheumatoid arthritis.	Ephedrine	13-22	tumor necrosis factor	Homo sapiens	58-67	
34799331-8	2021	In this assay, ephedrine (20 & 40 mg/kg orally) significantly suppressed the level of these inflammatory markers (PGE2 & TNF-alpha).	Ephedrine	15-24	tumor necrosis factor	Homo sapiens	121-130	
34799331-9	2021	Ephedrine exhibited anti-arthritic effect by decreasing pro-inflammatory cytokines (PGE2 & TNF-alpha).	Ephedrine	0-9	tumor necrosis factor	Homo sapiens	91-100	
31551774-3	2019	The MDCK cellular research results showed that, among nine predominant ingredients of MHT, L-methylephedrin (LMEP), L-ephedrine (LEP) and D-pseudo- ephedrine (DPEP) significantly inhibited the proliferation of influenza A virus in vitro, and the inhibitory effect at 24 h after the treatment was more obvious than that at 48 h. They also significantly inhibited the mRNA expression levels of related genes in the TLR3, TLR4 and TLR7 signaling pathways, which were accompanied with the down-regulation of TNF-alpha level and the up-regulation of IFN-beta level in the cell supernatant.	Ephedrine	116-127	tumor necrosis factor	Homo sapiens	504-513	
31551774-3	2019	The MDCK cellular research results showed that, among nine predominant ingredients of MHT, L-methylephedrin (LMEP), L-ephedrine (LEP) and D-pseudo- ephedrine (DPEP) significantly inhibited the proliferation of influenza A virus in vitro, and the inhibitory effect at 24 h after the treatment was more obvious than that at 48 h. They also significantly inhibited the mRNA expression levels of related genes in the TLR3, TLR4 and TLR7 signaling pathways, which were accompanied with the down-regulation of TNF-alpha level and the up-regulation of IFN-beta level in the cell supernatant.	Ephedrine	129-132	tumor necrosis factor	Homo sapiens	504-513	
31551774-3	2019	The MDCK cellular research results showed that, among nine predominant ingredients of MHT, L-methylephedrin (LMEP), L-ephedrine (LEP) and D-pseudo- ephedrine (DPEP) significantly inhibited the proliferation of influenza A virus in vitro, and the inhibitory effect at 24 h after the treatment was more obvious than that at 48 h. They also significantly inhibited the mRNA expression levels of related genes in the TLR3, TLR4 and TLR7 signaling pathways, which were accompanied with the down-regulation of TNF-alpha level and the up-regulation of IFN-beta level in the cell supernatant.	Ephedrine	118-127	tumor necrosis factor	Homo sapiens	504-513	
31551774-5	2019	Animal research further indicated, at the 3rd and 7th days after infection, LEP and DPEP significantly attenuated lung injury, decreased lung index, virus load in the lung and the level of IL-1beta in serum, inhibited the mRNA expression levels of TNF-alpha, TLR3, TLR4, TLR7, MyD88, NF-kappaB p65 and RIG-1 as well as the protein expression levels of TLR4, TLR7, MyD88 and NF-kappaB p65 and markedly increased thymus index, the level of IL-10 in serum and the mRNA expression level of IFN-gamma.	Ephedrine	76-79	tumor necrosis factor	Homo sapiens	248-257