PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20372827-6	2010	Forskolin, a direct activator of adenylyl cyclase, or 8-bromoadenosine-3",5"-cyclic monophosphate (8bromo-cAMP), a plasma membrane-permeable cAMP analogue, markedly enhanced the TNF-alpha-induced IL-6 synthesis as well as VIP.	8-Bromo Cyclic Adenosine Monophosphate	54-97	tumor necrosis factor	Mus musculus	178-187	
25150062-10	2014	In contrast, 8-Br-cAMP decreased HDE-stimulated tumor necrosis factor (TNF)-alpha-converting enzyme (TACE; ADAM-17) activity and subsequent TNF-alpha release (P < 0.001).	8-Bromo Cyclic Adenosine Monophosphate	13-22	tumor necrosis factor	Mus musculus	140-149	
23849041-8	2013	Rolipram, IBMX and 8-Br-cAMP also inhibited TNF production in activated macrophages.	8-Bromo Cyclic Adenosine Monophosphate	19-28	tumor necrosis factor	Mus musculus	44-47	
11350859-7	2001	This increase in serum TNF-alpha was completely blocked by a pretreatment with pentoxifylline (160 mg kg-1), milrinone (5 mg kg-1), rolipram (1 mg kg-1), zaprinast (10 mg kg-1), salbutamol (0.5 mg kg-1), forskolin (1 mg kg-1) and 8-Br-cAMP (10 mg kg-1).	8-Bromo Cyclic Adenosine Monophosphate	230-239	tumor necrosis factor	Mus musculus	23-32	
11857482-8	2002	TNFalpha did not affect basal or hCG-stimulated cAMP levels, but did inhibit forskolin (0.5 microM; adenylate cyclase activator) and 8-bromo-cAMP (0.15 mM; cAMP analog) stimulated T levels.	8-Bromo Cyclic Adenosine Monophosphate	133-145	tumor necrosis factor	Mus musculus	0-8	
9878303-10	1998	In the presence of LPS, both FSK and 8-Br-cAMP significantly reduced TNF-alpha release.	8-Bromo Cyclic Adenosine Monophosphate	37-46	tumor necrosis factor	Mus musculus	69-78	
10479401-9	1999	When tested with the 314 bp LIF-promoter construct, incubation of stromal cells with IL-1beta (500 U/ml) resulted in a 1.57-fold stimulation, with TNF-alpha (500 U/ml) in 2.06-fold stimulation, and with 8BrcAMP (0.5 mM) in a 3.	8-Bromo Cyclic Adenosine Monophosphate	203-210	tumor necrosis factor	Mus musculus	147-156	
9878303-11	1998	For instance at 6 h in the presence of LPS and FSK or 8-Br-cAMP, TNF-alpha was 126 +/- 24 and 71.6 +/- 22 units/g tissue, respectively (P < 0.05 vs LPS alone).	8-Bromo Cyclic Adenosine Monophosphate	54-63	tumor necrosis factor	Mus musculus	65-74	
9657065-2	1997	We have shown previously that both tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1-beta) inhibit 8-bromo-cAMP-(8-Br-cAMP)-stimulated steroidogenesis in mouse Leydig cells.	8-Bromo Cyclic Adenosine Monophosphate	118-130	tumor necrosis factor	Mus musculus	35-62	
9657065-2	1997	We have shown previously that both tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1-beta) inhibit 8-bromo-cAMP-(8-Br-cAMP)-stimulated steroidogenesis in mouse Leydig cells.	8-Bromo Cyclic Adenosine Monophosphate	118-130	tumor necrosis factor	Mus musculus	64-73	
9657065-5	1997	In the present study, we tested the effects of TNF and IL-1 on basal testosterone production and 8-Br-cAMP-stimulated 3 beta-hydroxysteroid dehydrogenase/delta 5-->delta 4 isomerase (3 beta HSD) expression in Leydig cells.	8-Bromo Cyclic Adenosine Monophosphate	97-106	tumor necrosis factor	Mus musculus	47-50	
9397943-5	1994	TNF-alpha (10 ng/ml) also markedly inhibited 8-bromo cAMP-induced testosterone formation from 76 +/- 9 ng/10(6) cells/h to 4.9 ng/10(6) cells/h.	8-Bromo Cyclic Adenosine Monophosphate	45-57	tumor necrosis factor	Mus musculus	0-9	
8062890-8	1994	Addition to stromal cells of the soluble cAMP agonist 8-bromo-cAMP (8BrcAMP) at 0.5 to 1 mM stimulated IL-6 mRNA expression acting alone, and it was additive with IL-1 or IL-1 plus TNF-alpha in stimulating IL-6 expression.	8-Bromo Cyclic Adenosine Monophosphate	54-66	tumor necrosis factor	Mus musculus	181-190	
8062890-8	1994	Addition to stromal cells of the soluble cAMP agonist 8-bromo-cAMP (8BrcAMP) at 0.5 to 1 mM stimulated IL-6 mRNA expression acting alone, and it was additive with IL-1 or IL-1 plus TNF-alpha in stimulating IL-6 expression.	8-Bromo Cyclic Adenosine Monophosphate	68-75	tumor necrosis factor	Mus musculus	181-190	
8062890-9	1994	On the other hand, 8BrcAMP inhibited GM-CSF mRNA expression stimulated by IL-1 or IL-1 plus TNF-alpha.	8-Bromo Cyclic Adenosine Monophosphate	19-26	tumor necrosis factor	Mus musculus	92-101	
7929839-13	1994	Preincubation of cells with 8 br-cAMP, forskolin, or PGE2 attenuated the increase in nuclear NF-kB in response to TNF-alpha, aggregated IgG, or superoxide anion.	8-Bromo Cyclic Adenosine Monophosphate	30-37	tumor necrosis factor	Mus musculus	114-123	
8464240-4	1993	Incubation with interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha) or the cAMP analogue 8-bromoadenosine 3":5"-monophosphate (8BrcAMP) resulted in weakly induced LIF mRNA.	8-Bromo Cyclic Adenosine Monophosphate	137-144	tumor necrosis factor	Mus musculus	38-65	
8504748-6	1993	TNF alpha caused a significant and dose-dependent inhibition of 8-Br-cAMP-stimulated testosterone secretion by 35.9 +/- 9.9%, 90.9 +/- 1.7%, and 96.9 +/- 1.4% with 0.1, 1.0, and 10.0 ng/ml TNF alpha, respectively.	8-Bromo Cyclic Adenosine Monophosphate	64-73	tumor necrosis factor	Mus musculus	0-9	
8504748-6	1993	TNF alpha caused a significant and dose-dependent inhibition of 8-Br-cAMP-stimulated testosterone secretion by 35.9 +/- 9.9%, 90.9 +/- 1.7%, and 96.9 +/- 1.4% with 0.1, 1.0, and 10.0 ng/ml TNF alpha, respectively.	8-Bromo Cyclic Adenosine Monophosphate	64-73	tumor necrosis factor	Mus musculus	189-198	
8504748-8	1993	Treatment with 0.1, 1.0, and 10.0 ng/ml TNF alpha decreased 8-Br-cAMP-stimulated P450scc mRNA by 11.5 +/- 6.9%, 29.3 +/- 2.7%, and 59.2 +/- 8.7%, and decreased 8-Br-cAMP-induced P450c17 mRNA 41.9 +/- 13.5%, 95.7 +/- 2.3%, and 98.5 +/- 1.2%, respectively.	8-Bromo Cyclic Adenosine Monophosphate	60-69	tumor necrosis factor	Mus musculus	40-49	
8504748-11	1993	Within 48 h after the removal of TNF alpha from culture, P450c17 mRNA was restored to 80.6 +/- 3.1% of the level in cultures treated with 8-Br-cAMP alone for 4 days.	8-Bromo Cyclic Adenosine Monophosphate	138-147	tumor necrosis factor	Mus musculus	33-42	
8504748-14	1993	These data demonstrate that TNF alpha inhibits both basal and 8-Br-cAMP-stimulated testosterone secretion from Leydig cells in a dose-dependent manner.	8-Bromo Cyclic Adenosine Monophosphate	62-71	tumor necrosis factor	Mus musculus	28-37