PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11956171-4	2002	We demonstrate that treatment of UMR 106-01 cells and rat calvarial osteoblasts with PTH (10(-8) M), N-terminal peptides of PTH that selectively activate PKA, or 8-bromo-cAMP (activates PKA) results in the inhibition of JNK activity from high basal levels.	8-Bromo Cyclic Adenosine Monophosphate	162-174	parathyroid hormone	Rattus norvegicus	124-127	
19505977-5	2009	PTH (1-34) and PTH (1-31) inhibited Osx mRNA and protein expression, and this effect could be mimicked by forskolin, 8-bromo-cAMP, or expression of constitutively active Gsalpha (caGsalpha).	8-Bromo Cyclic Adenosine Monophosphate	117-129	parathyroid hormone	Rattus norvegicus	0-3	
19505977-5	2009	PTH (1-34) and PTH (1-31) inhibited Osx mRNA and protein expression, and this effect could be mimicked by forskolin, 8-bromo-cAMP, or expression of constitutively active Gsalpha (caGsalpha).	8-Bromo Cyclic Adenosine Monophosphate	117-129	parathyroid hormone	Rattus norvegicus	15-18	
7619214-5	1995	8-Bromo-cAMP had no acute stimulatory effect but inhibited basal and insulin-stimulated 2-DOG transport at 16 h. This result suggested that the prolonged, but not the acute, effect of PTH was mediated by the generation of cAMP.	8-Bromo Cyclic Adenosine Monophosphate	0-12	parathyroid hormone	Rattus norvegicus	184-187	
10963042-7	2000	We also determined that the response could be mimicked by combining the effect of 8-bromo-cAMP and 12-O-tetradecanoyl-phorbol-13-acetate, stimulators of the protein kinase A and protein kinase C pathways, respectively, both known to be activated by PTH.	8-Bromo Cyclic Adenosine Monophosphate	82-94	parathyroid hormone	Rattus norvegicus	249-252	
9681485-6	1998	PTH also increased the sensitivity of UMR cells to 1,25(OH)2D from 10(-8) to 10(-10) M. PTH worked through the cAMP signaling pathway as evidenced by the lack of effect of PTH (3-34) and by the full activity of 8-bromo-cAMP.	8-Bromo Cyclic Adenosine Monophosphate	211-223	parathyroid hormone	Rattus norvegicus	0-3	
9681485-6	1998	PTH also increased the sensitivity of UMR cells to 1,25(OH)2D from 10(-8) to 10(-10) M. PTH worked through the cAMP signaling pathway as evidenced by the lack of effect of PTH (3-34) and by the full activity of 8-bromo-cAMP.	8-Bromo Cyclic Adenosine Monophosphate	211-223	parathyroid hormone	Rattus norvegicus	88-91	
9681485-6	1998	PTH also increased the sensitivity of UMR cells to 1,25(OH)2D from 10(-8) to 10(-10) M. PTH worked through the cAMP signaling pathway as evidenced by the lack of effect of PTH (3-34) and by the full activity of 8-bromo-cAMP.	8-Bromo Cyclic Adenosine Monophosphate	211-223	parathyroid hormone	Rattus norvegicus	88-91	
7588200-6	1995	C-PTH receptor number was increased up to 2-fold by pretreating ROS 17/2.8 cells with increasing doses of PTH-(1-34), PTH-(1-84), or 8-bromo-cAMP, whereas no change was observed in response to dexamethasone or PTH-(39-84).	8-Bromo Cyclic Adenosine Monophosphate	133-145	parathyroid hormone	Rattus norvegicus	0-5	
7588200-6	1995	C-PTH receptor number was increased up to 2-fold by pretreating ROS 17/2.8 cells with increasing doses of PTH-(1-34), PTH-(1-84), or 8-bromo-cAMP, whereas no change was observed in response to dexamethasone or PTH-(39-84).	8-Bromo Cyclic Adenosine Monophosphate	133-145	parathyroid hormone	Rattus norvegicus	2-5	
8137737-8	1994	The effect of PTH could be reproduced by the addition of 8-bromo-cAMP, but not by the phorbol ester phorbol myristate acetate.	8-Bromo Cyclic Adenosine Monophosphate	57-69	parathyroid hormone	Rattus norvegicus	14-17	
2542004-4	1989	Incubation with the cAMP analog 8-bromo-cAMP (8BrcAMP) increased the number of collagenase-staining cells in a dose-dependent manner (ED0.5 = 2.5 x 10(-4) M), but to a lower level than PTH, with the maximal effect producing about 15% positive cells.	8-Bromo Cyclic Adenosine Monophosphate	32-44	parathyroid hormone	Rattus norvegicus	185-188	
2542004-4	1989	Incubation with the cAMP analog 8-bromo-cAMP (8BrcAMP) increased the number of collagenase-staining cells in a dose-dependent manner (ED0.5 = 2.5 x 10(-4) M), but to a lower level than PTH, with the maximal effect producing about 15% positive cells.	8-Bromo Cyclic Adenosine Monophosphate	46-53	parathyroid hormone	Rattus norvegicus	185-188	
8203893-7	1994	Parathyroid hormone, in its stimulation of TIMP-2 mRNA, appears to act through a signal transduction pathway involving protein kinase A (PKA) since the increase in TIMP-2 mRNA is reproduced by treatment with the cAMP analogue, 8-bromo-cAMP (5 x 10(-3) M).	8-Bromo Cyclic Adenosine Monophosphate	227-239	parathyroid hormone	Rattus norvegicus	0-19	
1718728-4	1991	In UMR 106-01 cells, PTH receptors are strikingly down-regulated by pretreatment with 8-Br-cAMP or 3-isobutyl-1-methylxanthine for 2 days.	8-Bromo Cyclic Adenosine Monophosphate	86-95	parathyroid hormone	Rattus norvegicus	21-24