PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3678137-7	1987	IGF-I (6.5 nM) caused a 64% inhibition of 8-Br-cAMP-stimulated GH mRNA levels and a similar inhibition of GH secretion.	8-Bromo Cyclic Adenosine Monophosphate	42-51	insulin-like growth factor 1	Rattus norvegicus	0-5	
10537120-3	1999	IGF-I, either alone or in combination with FSH, did not affect intracellular cAMP levels, whereas it enhanced the effect of 8-bromo-cAMP on LH receptor mRNA production.	8-Bromo Cyclic Adenosine Monophosphate	124-136	insulin-like growth factor 1	Rattus norvegicus	0-5	
8156915-9	1994	8-Bromo-cAMP (0.1 mM) also markedly reduced IGF-I mRNA levels.	8-Bromo Cyclic Adenosine Monophosphate	0-12	insulin-like growth factor 1	Rattus norvegicus	44-49	
1651848-7	1991	The effects of 8 bromo-cAMP on progesterone secretion also was amplified (P less than 0.001) when IGF-I was present in the medium.	8-Bromo Cyclic Adenosine Monophosphate	15-27	insulin-like growth factor 1	Rattus norvegicus	98-103	
1770953-9	1991	When activators of protein kinase A, such as forskolin and 8-Br-cAMP were added to the culture medium opposite effects were observed on the mRNA levels of P4502C12 and IGF-I.	8-Bromo Cyclic Adenosine Monophosphate	59-68	insulin-like growth factor 1	Rattus norvegicus	168-173	
1706263-3	1991	In these primary cultures of uterine cells isolated from 19-day-old immature rats, 8-bromo-cAMP evokes significant increases in PR by 8 h with maximal increases by 24 h. This time course and magnitude of PR stimulation are similar to those evoked by maximally effective concentrations of estradiol (3 x 10(-9) M) or IGF-I (20 ng/ml).	8-Bromo Cyclic Adenosine Monophosphate	83-95	insulin-like growth factor 1	Rattus norvegicus	316-321	
2555688-7	1989	In cells overexpressing normal H-ras, 8-bromo-cyclic AMP inhibited the responses to all GFs except those to insulin and IGF-1.	8-Bromo Cyclic Adenosine Monophosphate	38-56	insulin-like growth factor 1	Rattus norvegicus	120-125	
7689695-1	1993	We have shown previously that exposure of rat uterine cells in primary culture to estradiol (E2), insulin-like growth factor-I (IGF-I), or agents which alter intracellular cAMP levels, such as cholera toxin plus isobutylmethylxanthine (CT + IBMX) and 8-Br-cAMP, results in the up-regulation of cellular levels of the progesterone receptor, an effect believed to be mediated through the activation of estrogen receptor (ER) and phosphorylation pathways.	8-Bromo Cyclic Adenosine Monophosphate	251-260	insulin-like growth factor 1	Rattus norvegicus	128-133	
2944738-10	1986	Insulin and IGF-I also significantly potentiated hCG-and 8-bromo-cAMP-induced testosterone formation.	8-Bromo Cyclic Adenosine Monophosphate	57-69	insulin-like growth factor 1	Rattus norvegicus	12-17