PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2268285-5	1990	In 45Ca2(+)-release studies it was shown that, in saponin-permeabilized insulin-exposed cells, preincubation with exogenous PGE2 or 8-bromo cyclic AMP decreased the sensitivity of 45Ca2+ release in response to Ins(1,4,5)P3, as demonstrated by an increase in the EC50 (concn.	8-Bromo Cyclic Adenosine Monophosphate	132-150	insulin	Homo sapiens	72-79	
12401517-6	2003	This effect of forskolin on the insulin gene was time- and concentration-dependent, and was mimicked by 8-bromo-cAMP.	8-Bromo Cyclic Adenosine Monophosphate	104-116	insulin	Homo sapiens	32-39	
8770928-3	1996	We demonstrate here that in single insulin-secreting HIT cells, forskolin and 8-bromo-cAMP, which stimulate Ca2+ influx through voltage-dependent Ca2+ channels (VDCC), cause a marked increase in the frequency, amplitude, and duration of Ca2+ transients evoked by hormones linked to PLC, such as arginine vasopressin (AVP) or bombesin.	8-Bromo Cyclic Adenosine Monophosphate	78-90	insulin	Homo sapiens	35-42	
7588248-12	1995	In addition, LDL inhibited insulin-stimulated HMG-CoA mRNA accumulation by 84% as well as the synergistic effects of insulin and FSH (by 94%) and of insulin and 8-bromo-cAMP (by 93%).	8-Bromo Cyclic Adenosine Monophosphate	161-173	insulin	Homo sapiens	27-34	
7614254-3	1995	However, on acute stimulation with 5mM 8-Br-cAMP and 10mM theophylline the HEP G2ins cells released predominantly insulin into the medium.	8-Bromo Cyclic Adenosine Monophosphate	39-48	insulin	Homo sapiens	114-121	
3031673-1	1987	In hepatocytes stimulated with 8-bromo-cAMP, insulin decreases the affinity of the cAMP-dependent protein kinase for cAMP, shifting the Ka without affecting the Vmax activity.	8-Bromo Cyclic Adenosine Monophosphate	31-43	insulin	Homo sapiens	45-52	
2419331-1	1986	The effect of 8-bromo-cAMP and forskolin on the phosphorylation state and protein kinase activity of the insulin receptor was evaluated in cultured IM-9 lymphoblasts.	8-Bromo Cyclic Adenosine Monophosphate	14-26	insulin	Homo sapiens	105-112	
2419331-2	1986	8-Bromo-cAMP (1 mM) or forskolin (10 microM) enhanced the phosphorylation of the insulin receptor purified from 32P-labeled cells by affinity chromatography on wheat germ agglutinin-agarose and immunoprecipitation with monoclonal antibody.	8-Bromo Cyclic Adenosine Monophosphate	0-12	insulin	Homo sapiens	81-88	
3894022-10	1985	Insulin also counteracted the effect of 8-bromo-cAMP on the enzyme synthesis.	8-Bromo Cyclic Adenosine Monophosphate	40-52	insulin	Homo sapiens	0-7	
6202683-2	1984	Stimulation of glucose release by 8-bromo-cAMP, which is not appreciably hydrolyzed by phosphodiesterase, was also inhibited by insulin in the presence of d-4-(3-butoxy-4-methoxybenzyl)-2- imidizolidione .	8-Bromo Cyclic Adenosine Monophosphate	34-46	insulin	Homo sapiens	128-135