PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2268285-5 1990 In 45Ca2(+)-release studies it was shown that, in saponin-permeabilized insulin-exposed cells, preincubation with exogenous PGE2 or 8-bromo cyclic AMP decreased the sensitivity of 45Ca2+ release in response to Ins(1,4,5)P3, as demonstrated by an increase in the EC50 (concn. 8-Bromo Cyclic Adenosine Monophosphate 132-150 insulin Homo sapiens 72-79 12401517-6 2003 This effect of forskolin on the insulin gene was time- and concentration-dependent, and was mimicked by 8-bromo-cAMP. 8-Bromo Cyclic Adenosine Monophosphate 104-116 insulin Homo sapiens 32-39 8770928-3 1996 We demonstrate here that in single insulin-secreting HIT cells, forskolin and 8-bromo-cAMP, which stimulate Ca2+ influx through voltage-dependent Ca2+ channels (VDCC), cause a marked increase in the frequency, amplitude, and duration of Ca2+ transients evoked by hormones linked to PLC, such as arginine vasopressin (AVP) or bombesin. 8-Bromo Cyclic Adenosine Monophosphate 78-90 insulin Homo sapiens 35-42 7588248-12 1995 In addition, LDL inhibited insulin-stimulated HMG-CoA mRNA accumulation by 84% as well as the synergistic effects of insulin and FSH (by 94%) and of insulin and 8-bromo-cAMP (by 93%). 8-Bromo Cyclic Adenosine Monophosphate 161-173 insulin Homo sapiens 27-34 7614254-3 1995 However, on acute stimulation with 5mM 8-Br-cAMP and 10mM theophylline the HEP G2ins cells released predominantly insulin into the medium. 8-Bromo Cyclic Adenosine Monophosphate 39-48 insulin Homo sapiens 114-121 3031673-1 1987 In hepatocytes stimulated with 8-bromo-cAMP, insulin decreases the affinity of the cAMP-dependent protein kinase for cAMP, shifting the Ka without affecting the Vmax activity. 8-Bromo Cyclic Adenosine Monophosphate 31-43 insulin Homo sapiens 45-52 2419331-1 1986 The effect of 8-bromo-cAMP and forskolin on the phosphorylation state and protein kinase activity of the insulin receptor was evaluated in cultured IM-9 lymphoblasts. 8-Bromo Cyclic Adenosine Monophosphate 14-26 insulin Homo sapiens 105-112 2419331-2 1986 8-Bromo-cAMP (1 mM) or forskolin (10 microM) enhanced the phosphorylation of the insulin receptor purified from 32P-labeled cells by affinity chromatography on wheat germ agglutinin-agarose and immunoprecipitation with monoclonal antibody. 8-Bromo Cyclic Adenosine Monophosphate 0-12 insulin Homo sapiens 81-88 3894022-10 1985 Insulin also counteracted the effect of 8-bromo-cAMP on the enzyme synthesis. 8-Bromo Cyclic Adenosine Monophosphate 40-52 insulin Homo sapiens 0-7 6202683-2 1984 Stimulation of glucose release by 8-bromo-cAMP, which is not appreciably hydrolyzed by phosphodiesterase, was also inhibited by insulin in the presence of d-4-(3-butoxy-4-methoxybenzyl)-2- imidizolidione . 8-Bromo Cyclic Adenosine Monophosphate 34-46 insulin Homo sapiens 128-135