PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23053667-5	2013	On the other hand, SQ22,536, but not ddAd, inhibited the effects of cAMP analogs 8-Br-cAMP and 8-CPT-cAMP on ERK phosphorylation and neuritogenesis, indicating that it acts not only as an AC blocker, but also as an inhibitor of the NCS.	8-Bromo Cyclic Adenosine Monophosphate	81-90	mitogen-activated protein kinase 1	Homo sapiens	109-112	
28162907-5	2017	A chemical cAMP analog 8-Br-cAMP also inhibited ERK phosphorylation and TNF and MCP-1 release.	8-Bromo Cyclic Adenosine Monophosphate	23-32	mitogen-activated protein kinase 1	Homo sapiens	48-51	
20178980-8	2010	8-Br-cAMP greatly increased the phosphorylation of CREB1 (Ser(133)) and ATF2 (Thr(71)) in a PKA-, PI3K-, and ERK-dependent fashion.	8-Bromo Cyclic Adenosine Monophosphate	0-9	mitogen-activated protein kinase 1	Homo sapiens	109-112	
22532442-4	2012	Forskolin (25 muM) and cAMP analogs (8-bromo-cAMP, dibutyryl-cAMP, and 8-chlorophenylthio-cAMP) stimulated ERK phosphorylation and neuritogenesis in NS-1 cells.	8-Bromo Cyclic Adenosine Monophosphate	37-49	mitogen-activated protein kinase 1	Homo sapiens	107-110	
16214133-10	2005	Taken together, these results demonstrate a novel pathway in ES cells that 8-Br-cAMP activate PLD through PKA and ERK1/2 and this ERK/PLD activation by 8-Br-cAMP is mediated by Src and Ras, separately.	8-Bromo Cyclic Adenosine Monophosphate	75-84	mitogen-activated protein kinase 1	Homo sapiens	114-117	
15772344-12	2005	8-Br-cAMP, an activator of PKA, induced phosphorylation of c-Raf-Ser259 and inhibited ERK activation without affecting caspase-3.	8-Bromo Cyclic Adenosine Monophosphate	0-9	mitogen-activated protein kinase 1	Homo sapiens	86-89	
12753285-10	2003	8-Br-cAMP and EGF conjointly increased ERK activation above that of either agonist alone in ADPKD cells, and this combined effect was abolished by PD98059, indicating that ERK was activated by EGF- and cAMP-responsive cascades that converge at MAPK.	8-Bromo Cyclic Adenosine Monophosphate	0-9	mitogen-activated protein kinase 1	Homo sapiens	39-42	
12753285-10	2003	8-Br-cAMP and EGF conjointly increased ERK activation above that of either agonist alone in ADPKD cells, and this combined effect was abolished by PD98059, indicating that ERK was activated by EGF- and cAMP-responsive cascades that converge at MAPK.	8-Bromo Cyclic Adenosine Monophosphate	0-9	mitogen-activated protein kinase 1	Homo sapiens	172-175	
12479852-3	2003	We found that 8-bromoadenosine-3",5"-cyclic-monophosphate (8Br-cAMP)-induced the activation of ERK and mitogen-activated protein kinase (MEK), but inhibited B-Raf kinase via a protein kinase A (PKA)-mediated mechanism.	8-Bromo Cyclic Adenosine Monophosphate	14-57	mitogen-activated protein kinase 1	Homo sapiens	95-98	
12479852-3	2003	We found that 8-bromoadenosine-3",5"-cyclic-monophosphate (8Br-cAMP)-induced the activation of ERK and mitogen-activated protein kinase (MEK), but inhibited B-Raf kinase via a protein kinase A (PKA)-mediated mechanism.	8-Bromo Cyclic Adenosine Monophosphate	59-67	mitogen-activated protein kinase 1	Homo sapiens	95-98	
16214133-0	2005	Activation of phospholipase D by 8-Br-cAMP occurs through novel pathway involving Src, Ras, and ERK in human endometrial stromal cells.	8-Bromo Cyclic Adenosine Monophosphate	33-42	mitogen-activated protein kinase 1	Homo sapiens	96-99	
12753285-6	2003	RESULTS: 8-Br-cAMP increased phosphorylated ERK (2.7- +/- 0.6-fold, N = 7), and B-Raf kinase activity (3.6- +/- 1.1-fold, N = 5) in cells from ADPKD kidneys; levels of phosphorylated Raf-1 were not changed.	8-Bromo Cyclic Adenosine Monophosphate	9-18	mitogen-activated protein kinase 1	Homo sapiens	44-47