PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22546480-12 2012 Mitotane (40muM) almost completely neutralized this positive effect and returned 8-Br-cAMP-induced StAR, CYP11A1, CYP17 and CYP21 mRNA to control levels. 8-Bromo Cyclic Adenosine Monophosphate 81-90 steroidogenic acute regulatory protein Homo sapiens 99-103 12050262-9 2002 Concordant with reduced steroid production, 8-Br-cAMP-stimulated StAR protein expression was reduced approximately 40% in granulosa cells, as were expression of StAR mRNA and StAR promoter activity. 8-Bromo Cyclic Adenosine Monophosphate 44-53 steroidogenic acute regulatory protein Homo sapiens 65-69 17242178-13 2007 Br-cAMP provides an additional means to rapidly modulate StAR expression independent of transcription by attenuating the nuclear and cytoplasmic instability mechanisms within the extended 3" UTR. 8-Bromo Cyclic Adenosine Monophosphate 0-7 steroidogenic acute regulatory protein Homo sapiens 57-61 9188726-1 1997 A proximal element from the human StAR gene promoter, containing the sequence (-105)TATCCTTGAC(-95), was shown to confer responsiveness to 8-Br-cAMP in the presence of steroidogenic factor 1 (SF-1) when placed behind a minimal thymidine kinase promoter or an SV40 promoter and transfected into BeWo cells which normally lack StAR and SF-1. 8-Bromo Cyclic Adenosine Monophosphate 139-148 steroidogenic acute regulatory protein Homo sapiens 34-38 11416034-2 2001 Basal levels of StAR messenger RNA (mRNA) in undifferentiated granulosa cells from prehierarchal (6- to 8-mm) follicles were consistently low, but detectable, and were significantly increased by treatment with 8-bromo-cAMP and FSH (but not LH) within 3-6 h of culture. 8-Bromo Cyclic Adenosine Monophosphate 210-222 steroidogenic acute regulatory protein Homo sapiens 16-20 11416034-3 2001 After 20 h of culture, 8-bromo-cAMP, FSH, and LH each increased StAR mRNA levels above those in control cultured cells, and the delayed response to LH treatment was associated with increased levels of LH receptor (LH-R) mRNA. 8-Bromo Cyclic Adenosine Monophosphate 23-35 steroidogenic acute regulatory protein Homo sapiens 64-68 10666334-6 2000 In contrast, steroidogenic acute regulatory (StAR) protein levels were increased by 8-Br-cAMP. 8-Bromo Cyclic Adenosine Monophosphate 84-93 steroidogenic acute regulatory protein Homo sapiens 13-43 10666334-6 2000 In contrast, steroidogenic acute regulatory (StAR) protein levels were increased by 8-Br-cAMP. 8-Bromo Cyclic Adenosine Monophosphate 84-93 steroidogenic acute regulatory protein Homo sapiens 45-49 10541561-4 1999 A combination of IGFs/insulin and 8-Br-cAMP increased StAR 7-9-fold. 8-Bromo Cyclic Adenosine Monophosphate 34-43 steroidogenic acute regulatory protein Homo sapiens 54-58 10541561-9 1999 In proliferating granulosa-lutein cells, both IGF-I and insulin increased StAR mRNA (3-fold) and 8-Br-cAMP increased StAR mRNA 4-fold, whereas a combination of IGF-I and 8-Br-cAMP had an additive effect on StAR mRNA expression (7-fold). 8-Bromo Cyclic Adenosine Monophosphate 97-106 steroidogenic acute regulatory protein Homo sapiens 117-121 10541561-9 1999 In proliferating granulosa-lutein cells, both IGF-I and insulin increased StAR mRNA (3-fold) and 8-Br-cAMP increased StAR mRNA 4-fold, whereas a combination of IGF-I and 8-Br-cAMP had an additive effect on StAR mRNA expression (7-fold). 8-Bromo Cyclic Adenosine Monophosphate 97-106 steroidogenic acute regulatory protein Homo sapiens 117-121 11089528-9 2000 A stable cAMP analog, 8-bromo-cAMP (1 mM), and insulin/IGF-I also evoked supraadditive StAR promoter expression. 8-Bromo Cyclic Adenosine Monophosphate 22-34 steroidogenic acute regulatory protein Homo sapiens 87-91 10473624-4 1999 When the putative C/EBP response elements were mutated, individually or together, a pronounced decline in basal StAR promoter activity in human granulosa-lutein cells resulted, but the fold stimulation of promoter activity by 8-Br-cAMP was unaffected. 8-Bromo Cyclic Adenosine Monophosphate 226-235 steroidogenic acute regulatory protein Homo sapiens 112-116 9405483-7 1997 32P was incorporated into StAR protein immunoprecipitated from COS-1 cell extracts, and a 10-min treatment with 8-bromo-cAMP increased 32P incorporation into the StAR preprotein. 8-Bromo Cyclic Adenosine Monophosphate 112-124 steroidogenic acute regulatory protein Homo sapiens 26-30 9405483-7 1997 32P was incorporated into StAR protein immunoprecipitated from COS-1 cell extracts, and a 10-min treatment with 8-bromo-cAMP increased 32P incorporation into the StAR preprotein. 8-Bromo Cyclic Adenosine Monophosphate 112-124 steroidogenic acute regulatory protein Homo sapiens 162-166 9188726-1 1997 A proximal element from the human StAR gene promoter, containing the sequence (-105)TATCCTTGAC(-95), was shown to confer responsiveness to 8-Br-cAMP in the presence of steroidogenic factor 1 (SF-1) when placed behind a minimal thymidine kinase promoter or an SV40 promoter and transfected into BeWo cells which normally lack StAR and SF-1. 8-Bromo Cyclic Adenosine Monophosphate 139-148 steroidogenic acute regulatory protein Homo sapiens 325-329 8923870-3 1996 The cyclic nucleotide analog, 8-bromo-cAMP (8-Br-cAMP), increased StAR mRNA in all cell types studied by a process requiring on-going RNA and protein synthesis. 8-Bromo Cyclic Adenosine Monophosphate 30-42 steroidogenic acute regulatory protein Homo sapiens 66-70 8923870-3 1996 The cyclic nucleotide analog, 8-bromo-cAMP (8-Br-cAMP), increased StAR mRNA in all cell types studied by a process requiring on-going RNA and protein synthesis. 8-Bromo Cyclic Adenosine Monophosphate 44-53 steroidogenic acute regulatory protein Homo sapiens 66-70 7761400-7 1995 Treatment of granulosa cells with 8-bromo-adenosine 3",5"-cyclic monophosphate for 24 hr increased StAR mRNA 3-fold or more. 8-Bromo Cyclic Adenosine Monophosphate 34-78 steroidogenic acute regulatory protein Homo sapiens 99-103