PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8062890-8	1994	Addition to stromal cells of the soluble cAMP agonist 8-bromo-cAMP (8BrcAMP) at 0.5 to 1 mM stimulated IL-6 mRNA expression acting alone, and it was additive with IL-1 or IL-1 plus TNF-alpha in stimulating IL-6 expression.	8-Bromo Cyclic Adenosine Monophosphate	54-66	interleukin 1 complex	Mus musculus	163-167	
9657065-5	1997	In the present study, we tested the effects of TNF and IL-1 on basal testosterone production and 8-Br-cAMP-stimulated 3 beta-hydroxysteroid dehydrogenase/delta 5-->delta 4 isomerase (3 beta HSD) expression in Leydig cells.	8-Bromo Cyclic Adenosine Monophosphate	97-106	interleukin 1 complex	Mus musculus	55-59	
7791343-14	1995	The combination of LPSp plus 8-bromo-cAMP blocked the augmentation of IL-1 without changing TNF inhibition.	8-Bromo Cyclic Adenosine Monophosphate	29-41	interleukin 1 complex	Mus musculus	70-74	
8062890-8	1994	Addition to stromal cells of the soluble cAMP agonist 8-bromo-cAMP (8BrcAMP) at 0.5 to 1 mM stimulated IL-6 mRNA expression acting alone, and it was additive with IL-1 or IL-1 plus TNF-alpha in stimulating IL-6 expression.	8-Bromo Cyclic Adenosine Monophosphate	54-66	interleukin 1 complex	Mus musculus	171-175	
8062890-8	1994	Addition to stromal cells of the soluble cAMP agonist 8-bromo-cAMP (8BrcAMP) at 0.5 to 1 mM stimulated IL-6 mRNA expression acting alone, and it was additive with IL-1 or IL-1 plus TNF-alpha in stimulating IL-6 expression.	8-Bromo Cyclic Adenosine Monophosphate	68-75	interleukin 1 complex	Mus musculus	163-167	
8062890-8	1994	Addition to stromal cells of the soluble cAMP agonist 8-bromo-cAMP (8BrcAMP) at 0.5 to 1 mM stimulated IL-6 mRNA expression acting alone, and it was additive with IL-1 or IL-1 plus TNF-alpha in stimulating IL-6 expression.	8-Bromo Cyclic Adenosine Monophosphate	68-75	interleukin 1 complex	Mus musculus	171-175	
8062890-9	1994	On the other hand, 8BrcAMP inhibited GM-CSF mRNA expression stimulated by IL-1 or IL-1 plus TNF-alpha.	8-Bromo Cyclic Adenosine Monophosphate	19-26	interleukin 1 complex	Mus musculus	74-78	
8062890-9	1994	On the other hand, 8BrcAMP inhibited GM-CSF mRNA expression stimulated by IL-1 or IL-1 plus TNF-alpha.	8-Bromo Cyclic Adenosine Monophosphate	19-26	interleukin 1 complex	Mus musculus	82-86	
8381071-3	1993	IL-1 significantly (P < 0.05) elevated ACTH release after incubation periods of 4, 8, and 24 h. IL-1-induced ACTH release was not additive to that of CRF, cholera toxin, 8-bromo-cAMP, or forskolin.	8-Bromo Cyclic Adenosine Monophosphate	173-185	interleukin 1 complex	Mus musculus	0-4	
1425417-5	1992	Treatment with 8-Br-cAMP plus 0.2 and 2 U/ml IL-1 decreased testosterone production to 63 +/- 14% and 41 +/- 19%, respectively, while 5, 10, and 20 U/ml IL-1 decreased testosterone production to less than 5% that of cells treated with 8-Br-cAMP alone.	8-Bromo Cyclic Adenosine Monophosphate	235-244	interleukin 1 complex	Mus musculus	45-49	
1425417-5	1992	Treatment with 8-Br-cAMP plus 0.2 and 2 U/ml IL-1 decreased testosterone production to 63 +/- 14% and 41 +/- 19%, respectively, while 5, 10, and 20 U/ml IL-1 decreased testosterone production to less than 5% that of cells treated with 8-Br-cAMP alone.	8-Bromo Cyclic Adenosine Monophosphate	235-244	interleukin 1 complex	Mus musculus	153-157	
1425417-8	1992	IL-1 caused a dose-dependent decrease in 8-Br-cAMP-stimulated P450c17 levels (0.2 U/ml by 31 +/- 9%, 2 U/ml by 82 +/- 12%, and 10 or 20 U/ml by 100% compared to that in cells treated with 8-Br-cAMP alone).	8-Bromo Cyclic Adenosine Monophosphate	41-50	interleukin 1 complex	Mus musculus	0-4	
1425417-11	1992	Within 12 h after the removal of IL-1, P450c17 mRNA was restored to 24%; after 24 h, to 36%; after 36 h, to 65%; and after 48 h, to 84% of that with 8-Br-cAMP alone.	8-Bromo Cyclic Adenosine Monophosphate	149-158	interleukin 1 complex	Mus musculus	33-37