PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16039847-10 2005 Br-cAMP stimulates substantial selective synthesis of 3.5 kb StAR mRNA despite this instability. 8-Bromo Cyclic Adenosine Monophosphate 0-7 steroidogenic acute regulatory protein Mus musculus 61-65 29887570-0 2018 Curcumin downregulates 8-br-cAMP-induced steroidogenesis in mouse Leydig cells by suppressing the expression of Cyp11a1 and StAR independently of the PKA-CREB pathway. 8-Bromo Cyclic Adenosine Monophosphate 23-32 steroidogenic acute regulatory protein Mus musculus 124-128 29887570-6 2018 On the contrary, the real-time PCR results showed that curcumin suppressed 8-br-cAMP-induced expression of Nr5a1 and Fos, which are crucial for cAMP-stimulated StAR and Cyp11a1 expression in Leydig cells. 8-Bromo Cyclic Adenosine Monophosphate 75-84 steroidogenic acute regulatory protein Mus musculus 160-164 24328340-6 2014 Also, 8-Br-cAMP stimulated steroidogenic acute regulatory protein (StAR) and cytochrome P450 side-chain cleavage enzyme (P450scc) mRNAs expression. 8-Bromo Cyclic Adenosine Monophosphate 6-15 steroidogenic acute regulatory protein Mus musculus 67-71 23159987-6 2013 The treatment of H295R or MA-10 cells (murine Leydig cell line) with 8Br-cAMP together with docosahexaenoic acid (DHA, an antagonist of the receptor) partially reduced StAR induction and steroidogenesis. 8-Bromo Cyclic Adenosine Monophosphate 69-77 steroidogenic acute regulatory protein Mus musculus 168-172 19179481-13 2009 Direct transfection of Star mRNA demonstrated that Br-cAMP stimulated a selective turnover of 3.5-kb mRNA independent of AURE, which may correspond to these reversal processes. 8-Bromo Cyclic Adenosine Monophosphate 51-58 steroidogenic acute regulatory protein Mus musculus 23-27 18040891-2 2007 Treatment of Y-1 cells with increasing concentrations (0.001-50 microg/ml) of dexamethasone for 24 h suppressed 8-Br-cAMP (0.5 mM)-stimulated StAR mRNA and protein levels and progesterone production in a dose-dependent manner. 8-Bromo Cyclic Adenosine Monophosphate 112-121 steroidogenic acute regulatory protein Mus musculus 142-146 18040891-3 2007 Treatment of Y-1 cells with 8-Br-cAMP (0.5 mM) for 1-24 h resulted in a marked increase in StAR mRNA levels. 8-Bromo Cyclic Adenosine Monophosphate 28-37 steroidogenic acute regulatory protein Mus musculus 91-95 18040891-6 2007 8-Br-cAMP increased histone H3 acetylation within the proximal region of the StAR gene promoter and coincubation with dexamethasone blocked this effect. 8-Bromo Cyclic Adenosine Monophosphate 0-9 steroidogenic acute regulatory protein Mus musculus 77-81 29118738-10 2017 Br-cAMP stimulation of primary and spliced StAR RNA at the gene loci were removed within 4 h in this dual CRISPR/Cas9 strategy before any effect on cytoplasmic mRNA and protein occurred. 8-Bromo Cyclic Adenosine Monophosphate 0-7 steroidogenic acute regulatory protein Mus musculus 43-47 25086053-3 2014 Treatment of MA-10 cells with the cAMP analog 8-bromo-cAMP (8-Br-cAMP), which stimulates steroidogenesis, triggers the interaction of 14-3-3gamma with the steroidogenic acute regulatory protein (STAR) in the cytosol, limiting STAR activity to basal levels. 8-Bromo Cyclic Adenosine Monophosphate 46-58 steroidogenic acute regulatory protein Mus musculus 155-193 25086053-3 2014 Treatment of MA-10 cells with the cAMP analog 8-bromo-cAMP (8-Br-cAMP), which stimulates steroidogenesis, triggers the interaction of 14-3-3gamma with the steroidogenic acute regulatory protein (STAR) in the cytosol, limiting STAR activity to basal levels. 8-Bromo Cyclic Adenosine Monophosphate 46-58 steroidogenic acute regulatory protein Mus musculus 195-199 25086053-3 2014 Treatment of MA-10 cells with the cAMP analog 8-bromo-cAMP (8-Br-cAMP), which stimulates steroidogenesis, triggers the interaction of 14-3-3gamma with the steroidogenic acute regulatory protein (STAR) in the cytosol, limiting STAR activity to basal levels. 8-Bromo Cyclic Adenosine Monophosphate 46-58 steroidogenic acute regulatory protein Mus musculus 226-230 25086053-3 2014 Treatment of MA-10 cells with the cAMP analog 8-bromo-cAMP (8-Br-cAMP), which stimulates steroidogenesis, triggers the interaction of 14-3-3gamma with the steroidogenic acute regulatory protein (STAR) in the cytosol, limiting STAR activity to basal levels. 8-Bromo Cyclic Adenosine Monophosphate 60-69 steroidogenic acute regulatory protein Mus musculus 155-193 25086053-3 2014 Treatment of MA-10 cells with the cAMP analog 8-bromo-cAMP (8-Br-cAMP), which stimulates steroidogenesis, triggers the interaction of 14-3-3gamma with the steroidogenic acute regulatory protein (STAR) in the cytosol, limiting STAR activity to basal levels. 8-Bromo Cyclic Adenosine Monophosphate 60-69 steroidogenic acute regulatory protein Mus musculus 195-199 25086053-3 2014 Treatment of MA-10 cells with the cAMP analog 8-bromo-cAMP (8-Br-cAMP), which stimulates steroidogenesis, triggers the interaction of 14-3-3gamma with the steroidogenic acute regulatory protein (STAR) in the cytosol, limiting STAR activity to basal levels. 8-Bromo Cyclic Adenosine Monophosphate 60-69 steroidogenic acute regulatory protein Mus musculus 226-230 15590984-12 2004 8-Br-cAMP (0.2 mM)-induced StAR D1 mRNA was decreased 30-40% by transfection with CXCL10. 8-Bromo Cyclic Adenosine Monophosphate 0-9 steroidogenic acute regulatory protein Mus musculus 27-34 15713539-3 2005 Each elevated StAR mRNA (three-fold after 6 h treatment) even with simultaneous stimulation by Br-cAMP. 8-Bromo Cyclic Adenosine Monophosphate 95-102 steroidogenic acute regulatory protein Mus musculus 14-18 11196444-1 2000 Herein we have compared StAR mRNA and protein levels in 8-Br-cAMP-treated mouse adrenocortical Y1 and the derived PKA mutant Kin-8 cell lines to evaluate the PKA requirement in StAR expression. 8-Bromo Cyclic Adenosine Monophosphate 56-65 steroidogenic acute regulatory protein Mus musculus 24-28 14511770-6 2003 Compared to the control, StAR mRNA levels increased and LH receptor mRNA levels decreased in a dose-dependent manner in the presence of increasing concentrations of hCG (3-100 ng/ml) and of increasing concentrations of 8-Br-cAMP (0.2-2 mM) after 4 h incubation. 8-Bromo Cyclic Adenosine Monophosphate 219-228 steroidogenic acute regulatory protein Mus musculus 25-29 12604660-2 2003 In agreement with published data, both StAR expression and progesterone production in MA-10 mouse Leydig tumor cells could be stimulated with hCG and 8Br-cAMP. 8-Bromo Cyclic Adenosine Monophosphate 150-158 steroidogenic acute regulatory protein Mus musculus 39-43 12604660-3 2003 Addition of aminoglutethimide, an inhibitor of cholesterol side chain cleavage (P450(scc)) enzyme, not only resulted in a drastic inhibition of progesterone production but also in an attenuation of StAR expression in response to either hCG or 8-Br-cAMP. 8-Bromo Cyclic Adenosine Monophosphate 243-252 steroidogenic acute regulatory protein Mus musculus 198-202 11223189-6 2001 A similar distribution of StAR mRNA in active polysome fractions was observed for both 8-Br-cAMP-treated Y1 and Kin-8 cells, as well as a 2-fold increase in incorporation of [35S]methionine into StAR, which indicated translation was not blocked in Kin-8 cells. 8-Bromo Cyclic Adenosine Monophosphate 87-96 steroidogenic acute regulatory protein Mus musculus 26-30 11346648-3 2001 MA-10 cells treated with 8-bromo-cAMP had increased acetylated histone H3 associated with the proximal (but not distal) StAR promoter, nascent StAR transcripts, and progesterone production within 15 min, whereas StAR mRNA increased at 30 min. 8-Bromo Cyclic Adenosine Monophosphate 25-37 steroidogenic acute regulatory protein Mus musculus 120-124 11346648-3 2001 MA-10 cells treated with 8-bromo-cAMP had increased acetylated histone H3 associated with the proximal (but not distal) StAR promoter, nascent StAR transcripts, and progesterone production within 15 min, whereas StAR mRNA increased at 30 min. 8-Bromo Cyclic Adenosine Monophosphate 25-37 steroidogenic acute regulatory protein Mus musculus 143-147 11346648-3 2001 MA-10 cells treated with 8-bromo-cAMP had increased acetylated histone H3 associated with the proximal (but not distal) StAR promoter, nascent StAR transcripts, and progesterone production within 15 min, whereas StAR mRNA increased at 30 min. 8-Bromo Cyclic Adenosine Monophosphate 25-37 steroidogenic acute regulatory protein Mus musculus 143-147 11346648-7 2001 We conclude that acetylation of H3 (but not H4) associated with the proximal promoter is associated with StAR gene transcription, that chromatin modification occurs in discrete regions of the promoter, that the initial steroidogenic response to 8-bromo-cAMP occurs prior to increased StAR mRNA accumulation, and that MA-10 cell StAR gene transcription and promoter-associated H3 acetylation are biphasic during a 6-h treatment period. 8-Bromo Cyclic Adenosine Monophosphate 245-257 steroidogenic acute regulatory protein Mus musculus 284-288 11346648-7 2001 We conclude that acetylation of H3 (but not H4) associated with the proximal promoter is associated with StAR gene transcription, that chromatin modification occurs in discrete regions of the promoter, that the initial steroidogenic response to 8-bromo-cAMP occurs prior to increased StAR mRNA accumulation, and that MA-10 cell StAR gene transcription and promoter-associated H3 acetylation are biphasic during a 6-h treatment period. 8-Bromo Cyclic Adenosine Monophosphate 245-257 steroidogenic acute regulatory protein Mus musculus 284-288 11196444-2 2000 StAR mRNA was induced by 8-Br-cAMP-treatment of both Y1 and Kin-8 cells with maximal expression levels in Kin-8 cells approximately 50% of that observed in Y1 cells. 8-Bromo Cyclic Adenosine Monophosphate 25-34 steroidogenic acute regulatory protein Mus musculus 0-4 11196444-5 2000 Consistent with this data, a 2-fold increase in incorporation of [35S]methionine into StAR was also observed after 8-Br-cAMP treatment of both cell lines. 8-Bromo Cyclic Adenosine Monophosphate 115-124 steroidogenic acute regulatory protein Mus musculus 86-90