PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32034306-0 2020 EGFR activates GDH1 transcription to promote glutamine metabolism through MEK/ERK/ELK1 pathway in glioblastoma. arginyl-glutamine 45-54 epidermal growth factor receptor Homo sapiens 0-4 32034306-4 2020 In this study, we found that glutamine metabolism was upregulated after EGFR activation in a GDH1 (glutamate dehydrogenase 1)-dependent manner. arginyl-glutamine 29-38 epidermal growth factor receptor Homo sapiens 72-76 32034306-10 2020 Collectively, our findings indicate that EGFR phosphorylates ELK1 to activate GDH1 transcription and glutaminolysis through MEK/ERK pathway, providing new insight into oncogenic alterations of glutamine metabolism. arginyl-glutamine 193-202 epidermal growth factor receptor Homo sapiens 41-45 31578313-2 2019 In addition to blocking EGFR-stimulated cell signaling, cetuximab can induce endocytosis of ASCT2, a glutamine transporter associated with EGFR in a complex, leading to glutathione biosynthesis inhibition and cellular sensitization to ROS. arginyl-glutamine 101-110 epidermal growth factor receptor Homo sapiens 139-143