PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19913079-9 2010 Of the VIOXX-related lactone derivatives, CRI-7 could prove useful in the prevention of hormone-dependent cancers, such as breast cancer, since in vitro it shows low cytotoxicity, it is a potent inhibitor of CYP17 activity and strong inducer of cell cycle arrest. Lactones 21-28 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 208-213