PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16388406-8	2006	MDR1-mediated transport of [3H]digoxin was inhibited only by lactone forms, and the rank order correlated with that of inhibitory effects on both CYP3A4/5 activities.	Lactones	61-68	ATP binding cassette subfamily B member 1	Homo sapiens	0-4	
16388406-0	2006	Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport.	Lactones	20-27	ATP binding cassette subfamily B member 1	Homo sapiens	103-107	
16384552-1	2006	Ivermectin is a potent antiparasitic drug from macrocyclic lactone (ML) family, which interacts with the ABC multidrug transporter P-glycoprotein (Pgp).	Lactones	59-66	ATP binding cassette subfamily B member 1	Homo sapiens	131-145	
16384552-1	2006	Ivermectin is a potent antiparasitic drug from macrocyclic lactone (ML) family, which interacts with the ABC multidrug transporter P-glycoprotein (Pgp).	Lactones	59-66	ATP binding cassette subfamily B member 1	Homo sapiens	147-150	
19429419-0	2009	Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells.	Lactones	20-27	ATP binding cassette subfamily B member 1	Homo sapiens	116-120	
19429419-1	2009	In the present study, the ability of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), also known as statins, to regulate the gene expression and function of multidrug resistance protein 1 (MDR1/P-glycoprotein) and differences between their acid and lactone forms were examined in human intestinal epithelial LS180 cells.	Lactones	271-278	ATP binding cassette subfamily B member 1	Homo sapiens	179-209	
19429419-1	2009	In the present study, the ability of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), also known as statins, to regulate the gene expression and function of multidrug resistance protein 1 (MDR1/P-glycoprotein) and differences between their acid and lactone forms were examined in human intestinal epithelial LS180 cells.	Lactones	271-278	ATP binding cassette subfamily B member 1	Homo sapiens	211-215	
19429419-1	2009	In the present study, the ability of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), also known as statins, to regulate the gene expression and function of multidrug resistance protein 1 (MDR1/P-glycoprotein) and differences between their acid and lactone forms were examined in human intestinal epithelial LS180 cells.	Lactones	271-278	ATP binding cassette subfamily B member 1	Homo sapiens	216-230	
19238649-0	2008	ABCB1 haplotypes differentially affect the pharmacokinetics of the acid and lactone forms of simvastatin and atorvastatin.	Lactones	76-83	ATP binding cassette subfamily B member 1	Homo sapiens	0-5	
19238649-3	2008	The simvastatin acid AUC(0-12h) was 60% larger, the atorvastatin AUC(0-infinity) 55% larger, and the atorvastatin half-life 24% longer in subjects with the ABCB1 TTT/TTT genotype (n = 12) than in those with the CGC/CGC genotype (n = 12) (P < 0.05), but there were no differences between the two genotypes with respect to the pharmacokinetics of the lactones of these drugs.	Lactones	352-360	ATP binding cassette subfamily B member 1	Homo sapiens	156-161	
11395570-4	2001	Both the lactone and carboxylate forms of CPT-11 and SN-38 were actively transported across the cell monolayers, mainly by the apical-localized P-gp pump.	Lactones	9-16	ATP binding cassette subfamily B member 1	Homo sapiens	144-148	
22039791-4	2012	Subpopulations of some strains or breeds of some species appear to be uniquely sensitive to the neurotoxic effects of the macrocyclic lactones due to enhanced brain penetration by these drugs as a result of a deficiency in P-glycoprotein arising as a result of a mutation in the MDR1 gene.	Lactones	134-142	ATP binding cassette subfamily B member 1	Homo sapiens	279-283	
17134887-0	2007	Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship.	Lactones	27-35	ATP binding cassette subfamily B member 1	Homo sapiens	41-55	
17134887-1	2007	P-glycoprotein (P-gp) is involved in the ATP-dependant cellular efflux of a large number of drugs including ivermectin, a macrocyclic lactone (ML) endectocide, widely used in livestock and human antiparasitic therapy.	Lactones	134-141	ATP binding cassette subfamily B member 1	Homo sapiens	0-14	
17134887-1	2007	P-glycoprotein (P-gp) is involved in the ATP-dependant cellular efflux of a large number of drugs including ivermectin, a macrocyclic lactone (ML) endectocide, widely used in livestock and human antiparasitic therapy.	Lactones	134-141	ATP binding cassette subfamily B member 1	Homo sapiens	16-20	
17134887-9	2007	According to the structural specificity of SEL and MOX, we conclude that the integrity of the sugar moiety is determinant to achieve the optimal interaction of macrocyclic lactones with P-gp.	Lactones	172-180	ATP binding cassette subfamily B member 1	Homo sapiens	186-190