PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19429419-0 2009 Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells. Lactones 20-27 ATP binding cassette subfamily B member 1 Homo sapiens 116-120 22039791-4 2012 Subpopulations of some strains or breeds of some species appear to be uniquely sensitive to the neurotoxic effects of the macrocyclic lactones due to enhanced brain penetration by these drugs as a result of a deficiency in P-glycoprotein arising as a result of a mutation in the MDR1 gene. Lactones 134-142 ATP binding cassette subfamily B member 1 Homo sapiens 279-283 19429419-1 2009 In the present study, the ability of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), also known as statins, to regulate the gene expression and function of multidrug resistance protein 1 (MDR1/P-glycoprotein) and differences between their acid and lactone forms were examined in human intestinal epithelial LS180 cells. Lactones 271-278 ATP binding cassette subfamily B member 1 Homo sapiens 179-209 19429419-1 2009 In the present study, the ability of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), also known as statins, to regulate the gene expression and function of multidrug resistance protein 1 (MDR1/P-glycoprotein) and differences between their acid and lactone forms were examined in human intestinal epithelial LS180 cells. Lactones 271-278 ATP binding cassette subfamily B member 1 Homo sapiens 211-215 19429419-1 2009 In the present study, the ability of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), also known as statins, to regulate the gene expression and function of multidrug resistance protein 1 (MDR1/P-glycoprotein) and differences between their acid and lactone forms were examined in human intestinal epithelial LS180 cells. Lactones 271-278 ATP binding cassette subfamily B member 1 Homo sapiens 216-230 16388406-8 2006 MDR1-mediated transport of [3H]digoxin was inhibited only by lactone forms, and the rank order correlated with that of inhibitory effects on both CYP3A4/5 activities. Lactones 61-68 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 19238649-0 2008 ABCB1 haplotypes differentially affect the pharmacokinetics of the acid and lactone forms of simvastatin and atorvastatin. Lactones 76-83 ATP binding cassette subfamily B member 1 Homo sapiens 0-5 19238649-3 2008 The simvastatin acid AUC(0-12h) was 60% larger, the atorvastatin AUC(0-infinity) 55% larger, and the atorvastatin half-life 24% longer in subjects with the ABCB1 TTT/TTT genotype (n = 12) than in those with the CGC/CGC genotype (n = 12) (P < 0.05), but there were no differences between the two genotypes with respect to the pharmacokinetics of the lactones of these drugs. Lactones 352-360 ATP binding cassette subfamily B member 1 Homo sapiens 156-161 17134887-0 2007 Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship. Lactones 27-35 ATP binding cassette subfamily B member 1 Homo sapiens 41-55 17134887-1 2007 P-glycoprotein (P-gp) is involved in the ATP-dependant cellular efflux of a large number of drugs including ivermectin, a macrocyclic lactone (ML) endectocide, widely used in livestock and human antiparasitic therapy. Lactones 134-141 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 17134887-1 2007 P-glycoprotein (P-gp) is involved in the ATP-dependant cellular efflux of a large number of drugs including ivermectin, a macrocyclic lactone (ML) endectocide, widely used in livestock and human antiparasitic therapy. Lactones 134-141 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 17134887-9 2007 According to the structural specificity of SEL and MOX, we conclude that the integrity of the sugar moiety is determinant to achieve the optimal interaction of macrocyclic lactones with P-gp. Lactones 172-180 ATP binding cassette subfamily B member 1 Homo sapiens 186-190 16388406-0 2006 Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport. Lactones 20-27 ATP binding cassette subfamily B member 1 Homo sapiens 103-107 16384552-1 2006 Ivermectin is a potent antiparasitic drug from macrocyclic lactone (ML) family, which interacts with the ABC multidrug transporter P-glycoprotein (Pgp). Lactones 59-66 ATP binding cassette subfamily B member 1 Homo sapiens 131-145 16384552-1 2006 Ivermectin is a potent antiparasitic drug from macrocyclic lactone (ML) family, which interacts with the ABC multidrug transporter P-glycoprotein (Pgp). Lactones 59-66 ATP binding cassette subfamily B member 1 Homo sapiens 147-150 11395570-4 2001 Both the lactone and carboxylate forms of CPT-11 and SN-38 were actively transported across the cell monolayers, mainly by the apical-localized P-gp pump. Lactones 9-16 ATP binding cassette subfamily B member 1 Homo sapiens 144-148