PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23134667-0	2013	Inhibition of TGF-beta signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone.	Lactones	47-55	transforming growth factor beta 1	Homo sapiens	14-22	
23134667-4	2013	In a screening program of natural compounds from fungi inhibiting the TGF-beta dependent expression of a reporter gene in HepG2 cells, we found that the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone inhibited the binding of the activated Smad2/3 transcription factors to the DNA and antagonized the cellular effects of TGF-beta including reporter gene activation and expression of TGF-beta induced genes in HepG2 and MDA-MB-231 cells.	Lactones	160-168	transforming growth factor beta 1	Homo sapiens	70-78	
23134667-4	2013	In a screening program of natural compounds from fungi inhibiting the TGF-beta dependent expression of a reporter gene in HepG2 cells, we found that the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone inhibited the binding of the activated Smad2/3 transcription factors to the DNA and antagonized the cellular effects of TGF-beta including reporter gene activation and expression of TGF-beta induced genes in HepG2 and MDA-MB-231 cells.	Lactones	160-168	transforming growth factor beta 1	Homo sapiens	365-373	
23134667-4	2013	In a screening program of natural compounds from fungi inhibiting the TGF-beta dependent expression of a reporter gene in HepG2 cells, we found that the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone inhibited the binding of the activated Smad2/3 transcription factors to the DNA and antagonized the cellular effects of TGF-beta including reporter gene activation and expression of TGF-beta induced genes in HepG2 and MDA-MB-231 cells.	Lactones	160-168	transforming growth factor beta 1	Homo sapiens	365-373