PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12049482-2 2001 Recently, we demonstrated that CPT-11 (lactone) is also a potent inhibitor of human acetylcholinesterase (AChE) at clinically relevant concentrations. Lactones 39-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 12049482-2 2001 Recently, we demonstrated that CPT-11 (lactone) is also a potent inhibitor of human acetylcholinesterase (AChE) at clinically relevant concentrations. Lactones 39-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 10570064-4 1999 The lactone form of CPT-11 resulted in apparent noncompetitive inhibition of electric eel and both human recombinant and erythrocyte AChE with K(i) values of 0.065, 0.19, and 0.29 microM, respectively. Lactones 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137