PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28300280-2	2018	Recently, we have reported that rapamycin, a macrocyclic lactone, attenuates human soluble BAFF (hsBAFF)-stimulated B-cell proliferation/survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway.	Lactones	57-64	protein phosphatase 2 phosphatase activator	Homo sapiens	175-186	
14677930-2	2003	Thus, an identical 200-fold reduction in protein phosphatase 2A (PP2A) inhibition is observed with either the saturated lactone (7) or with an analogue that lacks the entire lactone (15).	Lactones	120-127	protein phosphatase 2 phosphatase activator	Homo sapiens	49-63	
14677930-2	2003	Thus, an identical 200-fold reduction in protein phosphatase 2A (PP2A) inhibition is observed with either the saturated lactone (7) or with an analogue that lacks the entire lactone (15).	Lactones	120-127	protein phosphatase 2 phosphatase activator	Homo sapiens	65-69	
19592665-6	2009	Notably, a derivative of fostriecin lacking the entire lactone subunit demonstrated marked potency and selectivity for PP2A, while having substantially reduced and similar activity against PP1 and PP1/PP2A- PP5/PP2A-chimeras that have greatly increased sensitivity to both fostriecin and cytostatin.	Lactones	55-62	protein phosphatase 2 phosphatase activator	Homo sapiens	119-123