PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27172882-7	2016	The presence of two polymorphic loci on D. immitis P-glycoprotein-11 (Dim-pgp-11) correlated with loss of efficacy of macrocyclic lactone anthelmintics, suggesting that PGPs may be involved in macrocyclic lactone resistance in D. immitis.	Lactones	130-137	phosphoglycolate phosphatase	Homo sapiens	74-77	
27172882-10	2016	The inhibitory effect of these macrocyclic lactones on the transport of two fluorophore probes, Rhodamine 123 and Hoechst 33342, by Dim-PGP-11 has been studied.	Lactones	43-51	phosphoglycolate phosphatase	Homo sapiens	136-139	
27172882-12	2016	However, both avermectins and milbemycin preventives inhibited the transport of Hoechst 33342 by Dim-PGP-11 in a concentration-dependent and apparently saturable manner, although differences existed in terms of efficiency and potency of inhibition between the two sub-classes of macrocyclic lactones.	Lactones	291-299	phosphoglycolate phosphatase	Homo sapiens	101-104	
27172882-14	2016	The avermectins appear to bind the "R" binding site unlike the milbemycins, whereas both sub-classes of macrocyclic lactones might interact with the "H" site of D. immitis PGP-11.	Lactones	116-124	phosphoglycolate phosphatase	Homo sapiens	172-175	
10604726-8	1999	These results suggest that reversal of P-gp-mediated resistance to topotecan by PAK-200S was related to the restoration of cellular drug concentrations of the active lactone form of topotecan rather than a direct effect on topoisomerase-I function.	Lactones	166-173	phosphoglycolate phosphatase	Homo sapiens	39-43	
27172882-7	2016	The presence of two polymorphic loci on D. immitis P-glycoprotein-11 (Dim-pgp-11) correlated with loss of efficacy of macrocyclic lactone anthelmintics, suggesting that PGPs may be involved in macrocyclic lactone resistance in D. immitis.	Lactones	205-212	phosphoglycolate phosphatase	Homo sapiens	74-77