PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7918477-4	1994	Multifrequency phase-modulation spectroscopic analyses of the intrinsic fluorescence emissions of the two drug forms revealed a physical explanation for the extensive ring opening observed in the presence of human serum albumin (HSA): the protein exhibited a marked 200-fold binding preference for the carboxylate (K = 1.2 x 10(6) M-1) relative to the lactone (K approximately 5.5 x 10(3) M-1).	Lactones	352-359	albumin	Homo sapiens	214-233	
17896945-4	2007	A serious limitation to the clinical application of CPT is the strong affinity of its carboxylate form to human serum albumin (HSA) which destabilizes its active lactone form.	Lactones	162-169	albumin	Homo sapiens	127-130	
25946161-9	2015	Furthermore, molecular docking analysis revealed that either an 11-OH or a 16-OAc group spatially close to a five-membered lactone ring significantly facilitated the anchoring of these compounds within site I of the HSA pocket via hydrogen bonding (H-bonding) with Tyr150 or Lys199, respectively.	Lactones	123-130	albumin	Homo sapiens	216-219	
4042328-2	1985	We have synthesized a novel digoxin/bovine serum albumin conjugate via reductive ozonolysis of the lactone ring such that the carbohydrate moiety of digoxin remains intact.	Lactones	99-106	albumin	Homo sapiens	43-56	
14505797-3	2003	The carboxy form of many CPTs, including 9AC, preferentially binds to human serum albumin (HSA), which further reduces the equilibrium amount of active lactone and greatly decreases antitumor efficacy.	Lactones	152-159	albumin	Homo sapiens	76-89	
16983566-2	2007	Camptothecins exist in a pH dependent equilibrium between active lactone and inactive carboxy forms that can be altered by binding to human serum albumin (HSA).	Lactones	65-72	albumin	Homo sapiens	140-153	
17191836-6	2004	Quantitative structure-activity relationships (QSAR) of lactone binding on proteins (BLG and BSA) were performed by the measurement of lipophilicity and H-bond strength.	Lactones	56-63	albumin	Homo sapiens	93-96