PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23620484-4	2013	Using cell lines expressing the aforementioned transporters, we showed that the lipophilic AR-67 lactone form is a substrate for efflux transporters BCRP and MDR1.	Lactones	97-104	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	149-153	
23620484-6	2013	Notably, both BCRP and MDR1 conferred resistance to AR-67 lactone.	Lactones	58-65	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	14-18	
23620484-9	2013	In conclusion, BCRP- and MDR1-mediated efflux of AR-67 lactone confers resistance to AR-67, but OATP1B3-mediated uptake of the AR-67 carboxylate does not sensitize OATP1B3-expressing tumor cells.	Lactones	55-62	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	15-19	
19567673-8	2009	Preferential active transport of topotecan lactone over topotecan carboxylate was shown in vivo by vCSF lactone-to-carboxylate area under the curve ratios for wild-type, Mdr1a/b(-/-), Bcrp1(-/-), and Mdr1a/b(-/-)Bcrp1(-/-) mice of 5.69 +/- 0.83, 3.85 +/- 0.64, 3.61 +/- 0.46, and 0.78 +/- 0.19, respectively.	Lactones	43-50	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	184-189	
19567673-8	2009	Preferential active transport of topotecan lactone over topotecan carboxylate was shown in vivo by vCSF lactone-to-carboxylate area under the curve ratios for wild-type, Mdr1a/b(-/-), Bcrp1(-/-), and Mdr1a/b(-/-)Bcrp1(-/-) mice of 5.69 +/- 0.83, 3.85 +/- 0.64, 3.61 +/- 0.46, and 0.78 +/- 0.19, respectively.	Lactones	43-50	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	212-217