PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10462483-5	1999	In the current studies we determined if the sesquiterpene lactones, parthenolide and isohelenin, modulate iNOS gene expression in cultured rat aortic smooth muscle cells (RASMC) treated with lipopolysaccharide and interferon-gamma.	Lactones	58-66	nitric oxide synthase 2	Rattus norvegicus	106-110	
9786505-2	1998	We investigated whether andrographolide, a diterpenoid lactone found at Andrographis paniculata, influences the induction of the inducible nitric oxide synthase (iNOS) in RAW264.7 cells activated by bacterial endotoxin (LPS), as well as in the rats with endotoxic shock and in aortic rings treated with LPS.	Lactones	55-62	nitric oxide synthase 2	Rattus norvegicus	162-166	
22201994-7	2012	The NOS-2 was only present in endothelium-denuded aortic rings, as demonstrated by immunoblot with lactone treated rings.	Lactones	99-106	nitric oxide synthase 2	Rattus norvegicus	4-9	
22201994-9	2012	Both nitric oxide produced by NOS-2 and K+ channels are involved in the relaxant effect of the lactone.	Lactones	95-102	nitric oxide synthase 2	Rattus norvegicus	30-35