PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35091825-1	2022	Mechanistic target of rapamycin (mTOR) inhibitors are macrocyclic lactone antibiotics derived from Streptomyces hygroscopicus that prevent T lymphocyte activation and B cell differentiation.	Lactones	66-73	mechanistic target of rapamycin kinase	Homo sapiens	0-31	
28300280-2	2018	Recently, we have reported that rapamycin, a macrocyclic lactone, attenuates human soluble BAFF (hsBAFF)-stimulated B-cell proliferation/survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway.	Lactones	57-64	mechanistic target of rapamycin kinase	Homo sapiens	161-165	
22214465-4	2012	Everolimus (RAD001) is an oral antineoplastic agent derived from rapamycin, a macrocyclic lactone antibiotic, targeting the mammalian target of rapamycin (mTOR).	Lactones	90-97	mechanistic target of rapamycin kinase	Homo sapiens	124-153	
22214465-4	2012	Everolimus (RAD001) is an oral antineoplastic agent derived from rapamycin, a macrocyclic lactone antibiotic, targeting the mammalian target of rapamycin (mTOR).	Lactones	90-97	mechanistic target of rapamycin kinase	Homo sapiens	155-159	
33149623-3	2020	Rapamycin is a new type macrocyclic lactone, which can inhibit the serine/threonine protein kinase mTOR.	Lactones	36-43	mechanistic target of rapamycin kinase	Homo sapiens	99-103	
30166521-6	2018	We selected the mTOR-independent disaccharide trehalose and the mTOR-dependent macrolide lactone rapamycin autophagy inducers.	Lactones	89-96	mechanistic target of rapamycin kinase	Homo sapiens	64-68	
15691225-1	2005	Sirolimus (rapamycin) is a macrocyclic lactone isolated from a strain of Streptomyces hygroscopicus that inhibits the mammalian target of rapamycin (mTOR)-mediated signal-transduction pathways, resulting in the arrest of cell cycle of various cell types, including T- and B-lymphocytes.	Lactones	39-46	mechanistic target of rapamycin kinase	Homo sapiens	118-147	
15691225-1	2005	Sirolimus (rapamycin) is a macrocyclic lactone isolated from a strain of Streptomyces hygroscopicus that inhibits the mammalian target of rapamycin (mTOR)-mediated signal-transduction pathways, resulting in the arrest of cell cycle of various cell types, including T- and B-lymphocytes.	Lactones	39-46	mechanistic target of rapamycin kinase	Homo sapiens	149-153	
35091825-1	2022	Mechanistic target of rapamycin (mTOR) inhibitors are macrocyclic lactone antibiotics derived from Streptomyces hygroscopicus that prevent T lymphocyte activation and B cell differentiation.	Lactones	66-73	mechanistic target of rapamycin kinase	Homo sapiens	33-37