PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21697097-1	2011	CYP24A1 is a mitochondrial cytochrome P450 (CYP) that catabolizes 1alpha,25-dihydroxyvitamin D(3) (1alpha,25-(OH)(2)D(3)) to different products: calcitroic acid or 1alpha,25-(OH)(2)D(3)-26,23-lactone via multistep pathways commencing with C24 and C23 hydroxylation, respectively.	Lactones	192-199	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7	
17646648-0	2007	Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone.	Lactones	131-138	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	37-44	
17646648-1	2007	Studies of 25-hydroxyvitamin D(3)-24-hydroxylase (CYP24A1) have demonstrated that it is a bifunctional enzyme capable of the 24-hydroxylation of 1alpha,25-(OH)(2)D(3), leading to the excretory form, calcitroic acid, and 23-hydroxylation, culminating in 1alpha,25-(OH)(2)D(3)-26,23-lactone.	Lactones	281-288	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	50-57	
16816472-7	2006	In addition to the C-24 oxidation pathway, human CYP24A1 catalyzed also C-23 oxidation pathway to produce 1alpha, 25 (OH) (2)D(3)-26, 23-lactone.	Lactones	137-144	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	49-56