PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15837305-0	2005	Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor.	Lactones	31-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116	
10576684-1	1999	By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3fluorophenyl)-4-(4-methanesulfonylphenyl)-2 (5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained.	Lactones	63-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199	
10465547-0	1999	SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor.	Lactones	18-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88	
26434364-4	2015	Key elements in these total syntheses include: (1) FeCl3-catalyzed cationic cascade cyclization to construct podocarpane-type skeleton; (2) Mn(III)/Co(II)-catalyzed radical hydroxylation of alkene with high regio-, diastereo-, and chemoselectivities; (3) and a ketal-deprotection/lactone-opening/deprotonation/lactonization cascade.	Lactones	280-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153