PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10465547-0 1999 SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor. Lactones 18-25 mitochondrially encoded cytochrome c oxidase II Homo sapiens 83-88 26434364-4 2015 Key elements in these total syntheses include: (1) FeCl3-catalyzed cationic cascade cyclization to construct podocarpane-type skeleton; (2) Mn(III)/Co(II)-catalyzed radical hydroxylation of alkene with high regio-, diastereo-, and chemoselectivities; (3) and a ketal-deprotection/lactone-opening/deprotonation/lactonization cascade. Lactones 280-287 mitochondrially encoded cytochrome c oxidase II Homo sapiens 148-153 15837305-0 2005 Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor. Lactones 31-39 mitochondrially encoded cytochrome c oxidase II Homo sapiens 111-116 10576684-1 1999 By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3fluorophenyl)-4-(4-methanesulfonylphenyl)-2 (5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained. Lactones 63-70 mitochondrially encoded cytochrome c oxidase II Homo sapiens 194-199